Diagnostic and therapeutic arthroscopies gained popularity in the last 20 years. Optimal peri-operative pain management is therefore mandatory and represents a considerable progress in animal welfare, aiming to improve long-term orthopaedic recovery and performance in equine patients undergoing to surgery. The present study investigates the post-arthroscopic use of xylazine as intra-articular (IA) analgesic in the horse. Peripheral administration of this agent comes with a reduction of its systemic effects and analgesia is due to the binding with its local specific receptors. The study included 45 horses of various breed, sex, age and joint lesions referred for diagnostic or terapeutic arthroscopy. They were randomly divided into 3 goups and received one of three different IA treatments at the end of surgery: xylazine 1 mg/kg (X), morphine 0.1 mg/kg (M), saline 10 ml (S). Post-operative clinical evaluation of every horse at 15, 60 and 120 minutes after recovery, suggested that IA use of xylazine produces a better recovery and a better post-operative period. Plasma concentration of xylazine is about 100-170 ppb (0.1-0.17 μg/ml) suggesting a minimal absorption through the synovia. In most horses analgesic effect seems to be greater between recovery from anaesthesia and the first post-operative examination. Results of our study suggest a new post-operative analgesic protocol characterized by the absence of xylazine-related systemic effects, while attacking pain at its peripheral source.
Analgesia intrarticolare nel cavallo: impiego di alfa2 agonisti dopo chirurgia artroscopica. Dati preliminari
NANNARONE, Sara;BAZZICA, CHIARA;GIALLETTI, Rodolfo;DELLA ROCCA, Giorgia;PEPE, Marco
2008
Abstract
Diagnostic and therapeutic arthroscopies gained popularity in the last 20 years. Optimal peri-operative pain management is therefore mandatory and represents a considerable progress in animal welfare, aiming to improve long-term orthopaedic recovery and performance in equine patients undergoing to surgery. The present study investigates the post-arthroscopic use of xylazine as intra-articular (IA) analgesic in the horse. Peripheral administration of this agent comes with a reduction of its systemic effects and analgesia is due to the binding with its local specific receptors. The study included 45 horses of various breed, sex, age and joint lesions referred for diagnostic or terapeutic arthroscopy. They were randomly divided into 3 goups and received one of three different IA treatments at the end of surgery: xylazine 1 mg/kg (X), morphine 0.1 mg/kg (M), saline 10 ml (S). Post-operative clinical evaluation of every horse at 15, 60 and 120 minutes after recovery, suggested that IA use of xylazine produces a better recovery and a better post-operative period. Plasma concentration of xylazine is about 100-170 ppb (0.1-0.17 μg/ml) suggesting a minimal absorption through the synovia. In most horses analgesic effect seems to be greater between recovery from anaesthesia and the first post-operative examination. Results of our study suggest a new post-operative analgesic protocol characterized by the absence of xylazine-related systemic effects, while attacking pain at its peripheral source.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
