Role for the liver X receptor agonist 22-ketositosterol in preventing disease progression in an Alzheimer's disease mouse model

Our data suggest that LXR-activating 22-ketositosterol has potential therapeutic beneficial effects in the context of neurodegenerative 14765381, 0, Downloaded from https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70031 by Universita Di Perugia, Wiley Online Library on [16/04/2025]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License MARTENSET AL. conditions such as AD. It may prevent disease progression by promoting cholesterol efflux and possibly by mitigating AD-related neuro-inflammatory processes. Considering that 22-ketositosterol stands out for not inducing lipid accumulation in the liver or serum, unlike other synthetic LXR agonists, further investigation into its potential therapeutic application in diseases that could benefit from dampening inflammation and enhancing cholesterol efflux is warranted