From risk to prevention: Clinical and public health strategies to reduce Alzheimer's disease burden

The growing prevalence of Alzheimer's disease (AD) requires strategies that go beyond risk identification to active prevention. In a recent large cohort study, Lee and colleagues demonstrated a "dose-dependent" relationship between cumulative lifestyle risk and AD incidence, thus underlining the power of modifiable factors in modulating cognitive trajectories. This commentary explores the clinical and public health implications, highlighting how sustained behavioral interventions, early risk assessment, integrated care models, and population-level policies can reduce the burden of AD and improve cognitive health outcomes across aging societies.