To compare the clinical results and the cost effectiveness of urinary FSH and recombinant FSH in ovarian stimulation for IUI cycles. Prospective, randomized trial. University Hospital, Perugia, and A.G.UN.CO. Obstetrics and Gynaecology Centre, Rome, Italy. IUI cycles were performed in 67 infertile patients. Protocols of ovarian stimulation with urinary FSH or recombinant FSH were randomly assigned, for a total of 138 cycles performed (67 and 71, respectively). Number of mature follicles, days of stimulation, number of ampules, and IU used per cycle, biochemical/clinical pregnancy rates and cost-effectiveness ratio. Follicular development, length of stimulation, pregnancy and delivery rates were not statistically different. Although in the urinary FSH group a significantly higher number of IU of gonadotropins were used (815.5 ± 284.9 vs. 596.0 ± 253.8), the cost per cycle remained significantly lower (220.73 ± 94.72 vs. 318.50 ± 125.21). The cost-effectiveness ratio was €1,848.61 in the urinary FSH group and €2,512.61 in the recombinant FSH group. Urinary FSH and recombinant FSH are both effective in ovarian stimulation in IUI cycles. The urinary preparation is more cost effective due to the difference of its cost per IU.
Recombinant versus urinary follicle-stimulating hormone in intrauterine insemination cycles: a prospective randomized analysis of cost effectiveness
GERLI, Sandro;BINI, Vittorio;DI RENZO, Giancarlo
2004
Abstract
To compare the clinical results and the cost effectiveness of urinary FSH and recombinant FSH in ovarian stimulation for IUI cycles. Prospective, randomized trial. University Hospital, Perugia, and A.G.UN.CO. Obstetrics and Gynaecology Centre, Rome, Italy. IUI cycles were performed in 67 infertile patients. Protocols of ovarian stimulation with urinary FSH or recombinant FSH were randomly assigned, for a total of 138 cycles performed (67 and 71, respectively). Number of mature follicles, days of stimulation, number of ampules, and IU used per cycle, biochemical/clinical pregnancy rates and cost-effectiveness ratio. Follicular development, length of stimulation, pregnancy and delivery rates were not statistically different. Although in the urinary FSH group a significantly higher number of IU of gonadotropins were used (815.5 ± 284.9 vs. 596.0 ± 253.8), the cost per cycle remained significantly lower (220.73 ± 94.72 vs. 318.50 ± 125.21). The cost-effectiveness ratio was €1,848.61 in the urinary FSH group and €2,512.61 in the recombinant FSH group. Urinary FSH and recombinant FSH are both effective in ovarian stimulation in IUI cycles. The urinary preparation is more cost effective due to the difference of its cost per IU.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
