Objective: To compare the effectiveness of i.m. P and 17α-hydroxyprogesterone caproate (17-HPC) for luteal phase support, in patients undergoing IVF-ET cycles. Design: Prospective, randomized study. Setting: Patients undergoing IVF-ET in our Centers. Patient(s): The inclusion criteria were the use of GnRH down-regulation and aged <40 years. Intervention(s): A total of 300 cycles were randomly treated with either 17-HPC (341 mg every 3 days) or P (50 mg daily). Main Outcome Measure(s): The outcomes of IVF in both study groups were evaluated for biochemical pregnancy, miscarriage, clinical pregnancy, and ongoing pregnancy. Result(s): No difference was found in the main outcome parameters considered. Conclusion(s): Although the results of the study encourage the use of 17-HPC for luteal phase support in patients undergoing IVF-ET program, more studies are necessary to support the hypothesis that it can replace i.m. P-in-oil.

A prospective randomized study comparing intramuscular progesterone and 17-alfa-hydroxyprogesterone caproate in patients undergoing in vitro fertilization embryo-transfer cycles.

GERLI, Sandro;DI RENZO, Giancarlo;
2001

Abstract

Objective: To compare the effectiveness of i.m. P and 17α-hydroxyprogesterone caproate (17-HPC) for luteal phase support, in patients undergoing IVF-ET cycles. Design: Prospective, randomized study. Setting: Patients undergoing IVF-ET in our Centers. Patient(s): The inclusion criteria were the use of GnRH down-regulation and aged <40 years. Intervention(s): A total of 300 cycles were randomly treated with either 17-HPC (341 mg every 3 days) or P (50 mg daily). Main Outcome Measure(s): The outcomes of IVF in both study groups were evaluated for biochemical pregnancy, miscarriage, clinical pregnancy, and ongoing pregnancy. Result(s): No difference was found in the main outcome parameters considered. Conclusion(s): Although the results of the study encourage the use of 17-HPC for luteal phase support in patients undergoing IVF-ET program, more studies are necessary to support the hypothesis that it can replace i.m. P-in-oil.
2001
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/161360
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