Fentanil e sufentanil in infusione endovenosa continua durante anestesia con isofluorano nel cane: studio clinico di confronto

L’obiettivo del presente studio è quello di mettere a confronto due degli oppioidi maggiormente impiegati nella pratica clinica, ovvero fentanil e sufentanil, sul piano dell’efficacia analgesica, della sicurezza nei confronti dei sistemi cardiovascolare e respiratorio e della qualità di sedazione, induzione e risveglio dei pazienti. The intraoperative use of opioids is now routine practice as part of a balanced anaesthetic technique. Fentanyl is a well-known selective µ-opioid receptor agonist and is particularly suitable as an intraoperative analgesic because of its short onset and duration (Monk et al., 1988; Mendez and Selmi, 2003). Sufentanil, another µ-opioid receptor agonist, is the thienyl analogue of 4-nilinopiperidine (Bufalari et al., 2004; Mendez and Selmi, 2003). Both agents have been used for the induction and maintenance of analgesia, especially in humans (Bovill et al., 1984; Ahonen et al., 2000). To our knowledge, there are no clinical comparative reports of the infusion of fentanyl or sufentanil during isoflurane anaesthesia in dogs. The purpose of the study reported here was to determine the sedative, analgesic and cardiorespiratory effects during constant rate infusion of the two opioids during isoflurane anaesthesia in dogs undergoing orthopaedic surgery. We also aimed to investigate the propofol sparing induction dose and the quality of sedation, induction and recovery for each combination.