The effect of tributyltin-chloride (TBTC), dibu- tyltin-chloride (DBTC) and monobutyltin-chlor- ide (MBTC) on rainbow trout (Salmo irideus) nuclear DNA, was investigated by means of single cell gel electrophoresis (‘comet’ assay). Our data show that TBTC presents a marked genotoxic effect, whereas the genotoxic effect is less pronounced for DBTC and it is completely absent for MBTC. These results could be important in evaluating the environmental risks deriving from the use of these molecules as a antifouling agents in marine paints and as agricultural biocides.
DNA damage induced by organotins on trout nucleated erythrocytes
MORETTI, Massimo;
2001
Abstract
The effect of tributyltin-chloride (TBTC), dibu- tyltin-chloride (DBTC) and monobutyltin-chlor- ide (MBTC) on rainbow trout (Salmo irideus) nuclear DNA, was investigated by means of single cell gel electrophoresis (‘comet’ assay). Our data show that TBTC presents a marked genotoxic effect, whereas the genotoxic effect is less pronounced for DBTC and it is completely absent for MBTC. These results could be important in evaluating the environmental risks deriving from the use of these molecules as a antifouling agents in marine paints and as agricultural biocides.File in questo prodotto:
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