Under mildly basic and pH-controlled aqueous conditions the aminolysis of 1,2-epoxides 1a–g by alkyl- and arylamines 2a–k is generally highly regioselective giving the corresponding beta-amino alcohols in satisfactory to excellent yields.
A green route to β-amino alcohols via the uncatalyzed aminolysis of 1,2-epoxides by alkyl- and arylamines
BONOLLO, SIMONA;FRINGUELLI, Francesco;PIZZO, Ferdinando;VACCARO, Luigi
2006
Abstract
Under mildly basic and pH-controlled aqueous conditions the aminolysis of 1,2-epoxides 1a–g by alkyl- and arylamines 2a–k is generally highly regioselective giving the corresponding beta-amino alcohols in satisfactory to excellent yields.File in questo prodotto:
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