A new approach to improve gastric solubility and control intestinal release of drugs, based on the formation of new nanostructured compounds, is described. The nanostructured system is an inorganic-organic hybrid material constituted by an inorganic material, belonging to the hydrotalcite-like compound (HTlc), and by flurbiprofen (FLUR), a nonsteroidal antiinflammatory drug belonging to class II of BCS. HTlc is a inorganic solid able to lodge molecular anions into its interlayer region. It dissolves in acid conditions releasing the guests in the medium generating a supersaturation state. On the contrary, it is very stable in neutral or slightly alkaline conditions releasing the intercalated anions by ion exchange. This article describes: i) the nanocomposite (HTlc-FLUR) preparation and characterization; ii) the capability of HTlc to modify FLUR release, both in gastric and intestinal media; and iii) the ability of HTlc to modify FLUR gastric mucus permeation. A remarkable improvement of drug apparent solubility in gastric fluid, an enhancement of gastric mucus permeation and a drug controlled release in intestinal environment were observed

Effects of hydrotalcite-like nanostructured compounds on biopharmaceutical properties and release of BCS class II drugs: the case of flurbiprofen

PERIOLI, Luana;AMBROGI, Valeria;NOCCHETTI, Morena;ROSSI, Carlo
2011

Abstract

A new approach to improve gastric solubility and control intestinal release of drugs, based on the formation of new nanostructured compounds, is described. The nanostructured system is an inorganic-organic hybrid material constituted by an inorganic material, belonging to the hydrotalcite-like compound (HTlc), and by flurbiprofen (FLUR), a nonsteroidal antiinflammatory drug belonging to class II of BCS. HTlc is a inorganic solid able to lodge molecular anions into its interlayer region. It dissolves in acid conditions releasing the guests in the medium generating a supersaturation state. On the contrary, it is very stable in neutral or slightly alkaline conditions releasing the intercalated anions by ion exchange. This article describes: i) the nanocomposite (HTlc-FLUR) preparation and characterization; ii) the capability of HTlc to modify FLUR release, both in gastric and intestinal media; and iii) the ability of HTlc to modify FLUR gastric mucus permeation. A remarkable improvement of drug apparent solubility in gastric fluid, an enhancement of gastric mucus permeation and a drug controlled release in intestinal environment were observed
2011
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/167087
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