Background: The presence of psychiatric symptoms among patients with carcinoid tumors has been known for some time. However, few studies have examined the psychiatric coming from the real presence of symptoms of anxiety depression and HRQoL in this type of patients. Objectives: 1. To evaluate the prevalence of anxiety and depression and HRQoL in patients with carcinoid tumors. 2. To compare the anxious and depressive symptoms in patients with carcinoid tumors divided, according to the anatomical and functional classification internationally, in Gastro-Entero-Pancreatic (GEP) and non-Gastro- Entero-Pancreatic (non-GEP).Method: A total of 45 patients with carcinoid tumors are recruited consecutively during the activities of consultation and liaison psychiatry at the Santa Maria della Misericordia Hospital of Perugia. HRQoL was measured by the EORTC QLQ-C30 3.0 and GI.NET- 21, anxiety and depression by the Hospital Anxiety and Depression Scale. Results: 26.7% of our sample showed anxiety, while 44.4% depression. The patients with GEP showed higher level of anxiety and depression respect other group. The psychiatric symptoms more frequently reported from GEP group were: tension, worrying thoughts, restless, sadness, loss of interest, hopeless. At all assessments of quality of life patients with GEP reported higher levels of physical-, emotional-, cognitive-, and social function compared with non-GEP. Discussion and Conclusion: To our knowledge, this is the first Italian study that investigated the prevalence of anxiety and depression in patients with carcinoid tumors and the first that investigated the different distress degrees among GEP and non-GEP. These data can be explained with the most frequent carcinoid syndrome in patients with GEP. This aspect should be object of further studies with larger population and with dosage of plasma levels of tryptophan, platelet-rich plasma levels of serotonin and urine levels of 5-HIAA.
Health related quality of life, anxiety and depression among patients with carcinoid tumors
PISELLI, Massimiliano;COTICHELLI, PATRIZIO;MORETTI, Patrizia;ALPINI, AURORA;DE GIORGIO, GIUSEPPINA;FEROLLA, PIERO;QUARTESAN, Roberto
2010
Abstract
Background: The presence of psychiatric symptoms among patients with carcinoid tumors has been known for some time. However, few studies have examined the psychiatric coming from the real presence of symptoms of anxiety depression and HRQoL in this type of patients. Objectives: 1. To evaluate the prevalence of anxiety and depression and HRQoL in patients with carcinoid tumors. 2. To compare the anxious and depressive symptoms in patients with carcinoid tumors divided, according to the anatomical and functional classification internationally, in Gastro-Entero-Pancreatic (GEP) and non-Gastro- Entero-Pancreatic (non-GEP).Method: A total of 45 patients with carcinoid tumors are recruited consecutively during the activities of consultation and liaison psychiatry at the Santa Maria della Misericordia Hospital of Perugia. HRQoL was measured by the EORTC QLQ-C30 3.0 and GI.NET- 21, anxiety and depression by the Hospital Anxiety and Depression Scale. Results: 26.7% of our sample showed anxiety, while 44.4% depression. The patients with GEP showed higher level of anxiety and depression respect other group. The psychiatric symptoms more frequently reported from GEP group were: tension, worrying thoughts, restless, sadness, loss of interest, hopeless. At all assessments of quality of life patients with GEP reported higher levels of physical-, emotional-, cognitive-, and social function compared with non-GEP. Discussion and Conclusion: To our knowledge, this is the first Italian study that investigated the prevalence of anxiety and depression in patients with carcinoid tumors and the first that investigated the different distress degrees among GEP and non-GEP. These data can be explained with the most frequent carcinoid syndrome in patients with GEP. This aspect should be object of further studies with larger population and with dosage of plasma levels of tryptophan, platelet-rich plasma levels of serotonin and urine levels of 5-HIAA.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
