The aim of the present study was to compare pregnancy rates after intrauterine insemination (IUI) in two groups of women receiving CC, with or without high doses of phytoestrogens. We also investigated plasma hormonal levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2); follicular recruitment; and the differences in endometrial thickness and uterine artery blood flow, which are sensitive indicators of uterine receptivity METHODS: A total of 134 women aged 25–35 years, who were infertile for at least 2 years and who had oligomenorrhea or amenorrhea associated with a positive menstrual response to the intramuscular progesterone-challenge test were enrolled. They were randomly treated with CC (100 mg daily for 5 days) and CC (100 mg daily for 5 days) in combination with PE (1500 mg daily for 10 days). We estimated the difference in uterine artery pulsatily index, number of preovulatory follicles, endometrial thickness, and pregnancy rate. RESULTS: Both treatments increased follicle-stimulating hormone, luteinizing hormone, and 17_- estradiol plasma concentrations, but the differences were not statistically significant. However, the differences in endometrial thickness of the two groups were statistically significant. No significant differences in the pulsatility index values and in the number of preovulatory follicles were noted. CONCLUSION: A high dose of phytoestrogens can reverse the deleterious effects of clomiphene citrate on endometrial thickness and could contribute to higher pregnancy rates

High dose of phytoestrogens can reverse the antiestrogenic effects of clomiphene citrate on endometrium in patients undergoing IUI. A comparative study

GERLI, Sandro;DI RENZO, Giancarlo
2004

Abstract

The aim of the present study was to compare pregnancy rates after intrauterine insemination (IUI) in two groups of women receiving CC, with or without high doses of phytoestrogens. We also investigated plasma hormonal levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2); follicular recruitment; and the differences in endometrial thickness and uterine artery blood flow, which are sensitive indicators of uterine receptivity METHODS: A total of 134 women aged 25–35 years, who were infertile for at least 2 years and who had oligomenorrhea or amenorrhea associated with a positive menstrual response to the intramuscular progesterone-challenge test were enrolled. They were randomly treated with CC (100 mg daily for 5 days) and CC (100 mg daily for 5 days) in combination with PE (1500 mg daily for 10 days). We estimated the difference in uterine artery pulsatily index, number of preovulatory follicles, endometrial thickness, and pregnancy rate. RESULTS: Both treatments increased follicle-stimulating hormone, luteinizing hormone, and 17_- estradiol plasma concentrations, but the differences were not statistically significant. However, the differences in endometrial thickness of the two groups were statistically significant. No significant differences in the pulsatility index values and in the number of preovulatory follicles were noted. CONCLUSION: A high dose of phytoestrogens can reverse the deleterious effects of clomiphene citrate on endometrial thickness and could contribute to higher pregnancy rates
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11391/21202
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