Propargylic amines can be valid precursors for the synthesis of beta(3)-amino acids. This can be effected by a selenium-mediated conversion of the carbon-carbon triple bond to a, Se-phenyl selenocarboxylate intermediate. The reactive Se-phenyl selenocarboxylate intermediates can be trapped with water, alcohols, or the amine of an amino acid derivative to give beta(3)-amino acids, beta(3)-amino esters, or mixed peptides, respectively.
Stereoselective Synthesis of β3-Amino Acids and β-Oligopeptidesby Organoselenium Intermediates
TEMPERINI, Andrea;TERLIZZI, Raffaella Giovanna Pia;TIECCO, Marcello
2011
Abstract
Propargylic amines can be valid precursors for the synthesis of beta(3)-amino acids. This can be effected by a selenium-mediated conversion of the carbon-carbon triple bond to a, Se-phenyl selenocarboxylate intermediate. The reactive Se-phenyl selenocarboxylate intermediates can be trapped with water, alcohols, or the amine of an amino acid derivative to give beta(3)-amino acids, beta(3)-amino esters, or mixed peptides, respectively.File in questo prodotto:
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