Background: CD44 is a transmembrane glycoprotein known to bind hyaluronic acid (HA). This molecule is a multi-functional cell surface glycoprotein involved in lymphocyte homing and activation, tumor growth and metastasis. We have investigated the qualitative modification of CD44 in the regenerating liver as a model for studying cellular proliferation in vivo. Molecules involved in cell adhesion and the extracellular matrix (ECM), which influence differentiation, growth, cell-cell interactions and cellular polarity, play an important role in the liver regeneration. We studied the modulation of CD44 gene expression and its post-transcriptional modifications, analyzing the expression of different isoforms containing exon v6 in the regenerating liver, in sham operated liver and in the hepatoma cells H-35
Differetial expression of CD44 isoforms during liver regeneration in rats
DELLA FAZIA, Maria Agnese;PETTIROSSI, Valentina;AYROLDI, Emira Maria;RICCARDI, Carlo;SERVILLO, Giuseppe
2001
Abstract
Background: CD44 is a transmembrane glycoprotein known to bind hyaluronic acid (HA). This molecule is a multi-functional cell surface glycoprotein involved in lymphocyte homing and activation, tumor growth and metastasis. We have investigated the qualitative modification of CD44 in the regenerating liver as a model for studying cellular proliferation in vivo. Molecules involved in cell adhesion and the extracellular matrix (ECM), which influence differentiation, growth, cell-cell interactions and cellular polarity, play an important role in the liver regeneration. We studied the modulation of CD44 gene expression and its post-transcriptional modifications, analyzing the expression of different isoforms containing exon v6 in the regenerating liver, in sham operated liver and in the hepatoma cells H-35I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
