Abstract The stem cell factor (SCF), besides regulating hemopoietic stem cells homing and proliferation, has proliferative effects on hepatocytes and may be involved in liver regeneration.We investigate if ortotopic liver transplantation (OLT) and hepatic resection (HR) modify the concentration of soluble Stem Cell Factor (s-SCF) in peripheral blood of 15 Liver Transplant and 7 Hepatic Resection. s-Stem Cell Factor was measured by E LISA as ng/ml. s-Stem Cell Factor basal levels were higher in Liver Transplantation that in Hepatic Resection (818 ^ 349 vs. 479 ^ 79, p ¼ 0.005). A significant increase of s-Stem Cell Factor, peaking at postoperative day þ3, was seen after Liver Transplant (from 818 ^ 349 to 1212 ^ 461, p ¼ 0.01) and Hepatic Resection (from 479 ^ 79 to 698 ^ 122, p ¼ 0.004). s-Stem Cell Factor peak levels were higher after Liver Transplantation than HR ( p ¼ 0.0008). At day þ7 s-Stem Cell Factor concentration returned to baseline values. Liver Transplant have a higher basal s-Stem Cell Factor level than Hepatic Resection. These data show for the first time that liver injury affects s-Stem Cell Factor level and suggest that Stem Cell Factor may be involved also in clinical liver regeneration.
Implication of stem cell factor in human liver regeneration after transplantation and resection.
DONINI, Annibale;
2006
Abstract
Abstract The stem cell factor (SCF), besides regulating hemopoietic stem cells homing and proliferation, has proliferative effects on hepatocytes and may be involved in liver regeneration.We investigate if ortotopic liver transplantation (OLT) and hepatic resection (HR) modify the concentration of soluble Stem Cell Factor (s-SCF) in peripheral blood of 15 Liver Transplant and 7 Hepatic Resection. s-Stem Cell Factor was measured by E LISA as ng/ml. s-Stem Cell Factor basal levels were higher in Liver Transplantation that in Hepatic Resection (818 ^ 349 vs. 479 ^ 79, p ¼ 0.005). A significant increase of s-Stem Cell Factor, peaking at postoperative day þ3, was seen after Liver Transplant (from 818 ^ 349 to 1212 ^ 461, p ¼ 0.01) and Hepatic Resection (from 479 ^ 79 to 698 ^ 122, p ¼ 0.004). s-Stem Cell Factor peak levels were higher after Liver Transplantation than HR ( p ¼ 0.0008). At day þ7 s-Stem Cell Factor concentration returned to baseline values. Liver Transplant have a higher basal s-Stem Cell Factor level than Hepatic Resection. These data show for the first time that liver injury affects s-Stem Cell Factor level and suggest that Stem Cell Factor may be involved also in clinical liver regeneration.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
