Nucleotide excision repair (NER) is a key mechanism in cellular damage repair, and therefore in the cell’s response to cisplatin treatment in neoplastic diseases. In this paper we suggest a model of this complex mechanism, and study the corresponding identification problem. We propose a hybrid model of nucleotide excision repair, carry out a detailed identifiability analysis based on results from sensitivity analysis, and test a possible identification scheme, although based on simulated data. The proposed simulation approach is also relevant in planning measurement experiment.
A Hybrid Model of Nucleotide Excision Repair in Neoplastic Diseases: The Identification Problem.
BIANCONI, FORTUNATO;LILLACCI, GABRIELE;VALIGI, Paolo
2007
Abstract
Nucleotide excision repair (NER) is a key mechanism in cellular damage repair, and therefore in the cell’s response to cisplatin treatment in neoplastic diseases. In this paper we suggest a model of this complex mechanism, and study the corresponding identification problem. We propose a hybrid model of nucleotide excision repair, carry out a detailed identifiability analysis based on results from sensitivity analysis, and test a possible identification scheme, although based on simulated data. The proposed simulation approach is also relevant in planning measurement experiment.File in questo prodotto:
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