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EnglishNucleotide excision repair (NER) is a key mechanism in cellular damage repair, and therefore in the cell’s response to cisplatin treatment in neoplastic diseases. In this paper we suggest a model of this complex mechanism, and study the corresponding identification problem. We propose a hybrid model of nucleotide excision repair, carry out a detailed identifiability analysis based on results from sensitivity analysis, and test a possible identification scheme, although based on simulated data. The proposed simulation approach is also relevant in planning measurement experiment.
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| Titolo: | A Hybrid Model of Nucleotide Excision Repair in Neoplastic Diseases: The Identification Problem. |
| Autori: | |
| Data di pubblicazione: | 2007 |
| Abstract: | Nucleotide excision repair (NER) is a key mechanism in cellular damage repair, and therefore in the cell’s response to cisplatin treatment in neoplastic diseases. In this paper we suggest a model of this complex mechanism, and study the corresponding identification problem. We propose a hybrid model of nucleotide excision repair, carry out a detailed identifiability analysis based on results from sensitivity analysis, and test a possible identification scheme, although based on simulated data. The proposed simulation approach is also relevant in planning measurement experiment. |
| Handle: | http://hdl.handle.net/11391/33196 |
| ISBN: | 9789608902855 |
| Appare nelle tipologie: | 4.1 Contributo in Atti di convegno |
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