INTRODUCTION AND OBJECTIVE: We investigated the effectiveness and safety of botulinum-A toxin (BONT/A)injections into the detrusor muscle in a group of spinal cord injured (SCI) patients with detrusor overactivity unresponsive to conventional anticholinergics, who reached a follow up longer than 6 years. METHODS: Since October 2000, 83 patients with refractory neurogenic and non-neurogenic detrusor overactivity, bladder hypersensitive disorders and BPH have been treated at our institution with intravesical BoNT/A. Among them, 17 SCI patients reached a follow up longer than 6 years and received multiple treatments along time. We reviewed clinical evaluations, voiding charts, frequency of urinary tract infections-UTI, imaging assessment of the upper urinary tract (UUT), and urodynamics, as well as patients’ drop out and satisfaction. CONCLUSIONS: Intravesical BoNT/A represents a valuable treatment for refractory neurogenic detrusor overactivity over a long clinical term follow up.

Six years followup of botulinum A toxin intradetrusorial injections in patients with refractory neurogenic detrusor overactivity: clinical and urodynamic results.

GIANNANTONI, Antonella;MEARINI, Ettore;ZUCCHI, ALESSANDRO;PORENA, Massimo
2008

Abstract

INTRODUCTION AND OBJECTIVE: We investigated the effectiveness and safety of botulinum-A toxin (BONT/A)injections into the detrusor muscle in a group of spinal cord injured (SCI) patients with detrusor overactivity unresponsive to conventional anticholinergics, who reached a follow up longer than 6 years. METHODS: Since October 2000, 83 patients with refractory neurogenic and non-neurogenic detrusor overactivity, bladder hypersensitive disorders and BPH have been treated at our institution with intravesical BoNT/A. Among them, 17 SCI patients reached a follow up longer than 6 years and received multiple treatments along time. We reviewed clinical evaluations, voiding charts, frequency of urinary tract infections-UTI, imaging assessment of the upper urinary tract (UUT), and urodynamics, as well as patients’ drop out and satisfaction. CONCLUSIONS: Intravesical BoNT/A represents a valuable treatment for refractory neurogenic detrusor overactivity over a long clinical term follow up.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11391/40269
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