Antihypertensive therapy may lead to a decrease in pulse pressure (PP), which does not necessarily parallel that of systolic and diastolic blood pressure (BP).1 A spontaneous increase in PP over time has been associated with subsequent cardiovascular events.2,3 However, the prognostic benefits of treatment- induced PP reduction compared with the reduction in steady BP components (systolic, diastolic, and mean) remain to be determined in prospective outcome studies. In the setting of the Progetto Ipertensione Umbria Monitoraggio Ambulatoriale (PIUMA) study,4,5 we undertook the present analysis to assess the prognostic significance of changes in PP and mean BP induced by antihypertensive treatment in subjects who attended the pretreatment and follow-up visits and were free of cardiovascular disease. We measured 24-hour ambulatory BP, which is superior to office BP for cardiovascular risk stratification in subjects with essential hypertension.4,6,7 In particular, ambulatory PP is a stronger risk marker than office PP.
Prognostic value of treatment-induced changes in twenty-four-hour mean and pulse pressures in adult hypertensive patients.
SCHILLACI, Giuseppe;PASQUALINI, Leonella;VAUDO, Gaetano;LUPATTELLI, Graziana;PIRRO, Matteo;MANNARINO, Elmo
2002
Abstract
Antihypertensive therapy may lead to a decrease in pulse pressure (PP), which does not necessarily parallel that of systolic and diastolic blood pressure (BP).1 A spontaneous increase in PP over time has been associated with subsequent cardiovascular events.2,3 However, the prognostic benefits of treatment- induced PP reduction compared with the reduction in steady BP components (systolic, diastolic, and mean) remain to be determined in prospective outcome studies. In the setting of the Progetto Ipertensione Umbria Monitoraggio Ambulatoriale (PIUMA) study,4,5 we undertook the present analysis to assess the prognostic significance of changes in PP and mean BP induced by antihypertensive treatment in subjects who attended the pretreatment and follow-up visits and were free of cardiovascular disease. We measured 24-hour ambulatory BP, which is superior to office BP for cardiovascular risk stratification in subjects with essential hypertension.4,6,7 In particular, ambulatory PP is a stronger risk marker than office PP.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
