Mast cells and arachidonic acid cascade in inflammation

Caraffa, Auro; Castellani, Ml; Felaco, M; Pandolfi, F; Salini, V; De Amicis, D; Vecchiet, J; Tetè, S; Ciampoli, C; Conti, F; Cerulli, Giuliano Giorgio; Antinolfi, Pierluigi; Cuccurullo, C; Felaco, P; Kempuraj, D; Boscolo, P; Sabatino, G; Shaik, Yb

Prostaglandin D2 PGD2 is a major cyclooxygenase metabolite of arachidonic acid produced by mast cells and it is released following allergen challenge in diseases, such as allergic diseases. PGD2 may act as a neuromodulator and as an allergic and inflammatory mediator. In allergic diseases, activated mast cell synthesizes prostaglandin D2 (first cyclo-oxygenate mediator) which has bronchoconstrictive and vasodilating effects and attracts several leukocytes. It has been found that activated mast cells, challenged with physiological and non- physiological secretagogues, release elovated histamine and tryptase and chymase, leukotrienes 134, C4 and D4, 5-hydroxyeicosatetraenoic acid, PGD2, Platelet Activating Factor (PAF), heparin, and high-molecular-weight neutrophil chemotactic factor and cytokines/chemokines. PGD2 exerts its biological activity through the DP and CRTH2 receptors and their cDNA cloning which were characterized 15 years ago. In this report, we revisited the biological effects of arachidonic acid compounds released by activated mast cells in allergic and inflammotory states.

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Titolo:	Mast cells and arachidonic acid cascade in inflammation
Autori:	CARAFFA, Auro Castellani ML Felaco M Pandolfi F Salini V De Amicis D Vecchiet J Tetè S Ciampoli C Conti F CERULLI, Giuliano Giorgio ANTINOLFI, PIERLUIGI Cuccurullo C Felaco P Kempuraj D Boscolo P Sabatino G Shaik YB mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2009
Rivista:	EUROPEAN JOURNAL OF INFLAMMATION
Abstract:	Prostaglandin D2 PGD2 is a major cyclooxygenase metabolite of arachidonic acid produced by mast c...ells and it is released following allergen challenge in diseases, such as allergic diseases. PGD2 may act as a neuromodulator and as an allergic and inflammatory mediator. In allergic diseases, activated mast cell synthesizes prostaglandin D2 (first cyclo-oxygenate mediator) which has bronchoconstrictive and vasodilating effects and attracts several leukocytes. It has been found that activated mast cells, challenged with physiological and non- physiological secretagogues, release elovated histamine and tryptase and chymase, leukotrienes 134, C4 and D4, 5-hydroxyeicosatetraenoic acid, PGD2, Platelet Activating Factor (PAF), heparin, and high-molecular-weight neutrophil chemotactic factor and cytokines/chemokines. PGD2 exerts its biological activity through the DP and CRTH2 receptors and their cDNA cloning which were characterized 15 years ago. In this report, we revisited the biological effects of arachidonic acid compounds released by activated mast cells in allergic and inflammotory states.
Handle:	http://hdl.handle.net/11391/639317
Appare nelle tipologie:	1.1 Articolo in rivista

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