Our limited knowledge regarding the genetic diversity of horses impacts our ability to correctly define population-based issues, identify and preserve characteristics that define particular breeds, and decipher the history of the modern horse and the basis of numerous complex genetic traits. The Equine Genetic Diversity Consortium (EGDC) represents a collaborative, international community of equine researchers who are working to build a comprehensive understanding of genetic diversity among equine populations across the world. To date, tissue samples, DNA, and genotypes, contributed by members of the EGDC represent over 850 horses from more than 30 breeds. Genotyping of the entire sample set at 54,000 SNP loci (Illumina Equine SNP50 Beadchip) is underway. Data are being utilized to quantify diversity (e.g. Ne, FST, observed heterozygosity, FIS), define population relationships (e.g. STRUCTURE, ADMIXTURE and parsimony analyses), and to identify markers informative for ancestry (e.g. PCA and Infocalc). Thus far, 17 breeds have been evaluated and show substantial variability; estimates of Ne range from 186 – 463, pairwise FST values (between breeds) from 0.01 – 0.16, and FIS (within breed) between 0.0 and 0.06. Sample and genotype collection is ongoing and these data will be updated as the project progresses. Once complete, this data set should stimulate new studies into the origins of breeds and breed-defining traits, and guide efforts to preserve genetic diversity.
The Equine Genetic Diversity Consortium: an international collaboration to describe genetic variation in modern horse breeds
FELICETTI, MICHELA;SILVESTRELLI, Maurizio;
2011
Abstract
Our limited knowledge regarding the genetic diversity of horses impacts our ability to correctly define population-based issues, identify and preserve characteristics that define particular breeds, and decipher the history of the modern horse and the basis of numerous complex genetic traits. The Equine Genetic Diversity Consortium (EGDC) represents a collaborative, international community of equine researchers who are working to build a comprehensive understanding of genetic diversity among equine populations across the world. To date, tissue samples, DNA, and genotypes, contributed by members of the EGDC represent over 850 horses from more than 30 breeds. Genotyping of the entire sample set at 54,000 SNP loci (Illumina Equine SNP50 Beadchip) is underway. Data are being utilized to quantify diversity (e.g. Ne, FST, observed heterozygosity, FIS), define population relationships (e.g. STRUCTURE, ADMIXTURE and parsimony analyses), and to identify markers informative for ancestry (e.g. PCA and Infocalc). Thus far, 17 breeds have been evaluated and show substantial variability; estimates of Ne range from 186 – 463, pairwise FST values (between breeds) from 0.01 – 0.16, and FIS (within breed) between 0.0 and 0.06. Sample and genotype collection is ongoing and these data will be updated as the project progresses. Once complete, this data set should stimulate new studies into the origins of breeds and breed-defining traits, and guide efforts to preserve genetic diversity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
