The authors studied the presence of substance P (SP) and vasoactive intestinal polypeptide (VIP) and their related fibers in the lower uterine segment (LUS) in 133 women undergoing cesarean sections (CS) during active labor These were divided into 2 groups women undergoing repeat or first CSs Specimens were collected from the LUS and were evaluated by light microscopy and by immunohistochemistry for the morphometrical quantification of the SP and VIP fibers in the LUS The SP amount was higher in the post-CS scar while the VIP amount decreased nerve fibers contained an SP amount of up to 13 +/- 2 6 C U while nerve fibers contained a VIP amount of up to 7 +/- 1 9 C U The SP amount counts 10 +/- 1 5% of the total Bodian fibers and the ratio of the VIP is 10 +/- 1 8% of their total amount In normal conditions only 661 C U of the Bodian surface is occupied by SP related nerve fibers in contrast to 663 C U of the total surface by VIP the amount of SP increased up to 13 +/- 2 6 C U while it decreased in the LUS previous scars The SP levels are higher in repeat CS while the VIP levels are reduced in the LUS The Increase of SP is probably linked to the attempt to achieve cervical ripening in a post-CS LUS with the possible consequences of dystocia during vaginal birth after CS Nevertheless the decrease of VIP probably affects the relaxation of the internal uterine orifice compromising the LUS formation and cervical ripening

Substance P (SP) and vasoactive intestinal polypeptide (VIP) in the lower uterine segment in first and repeated cesarean sections.

DI RENZO, Giancarlo;
2010

Abstract

The authors studied the presence of substance P (SP) and vasoactive intestinal polypeptide (VIP) and their related fibers in the lower uterine segment (LUS) in 133 women undergoing cesarean sections (CS) during active labor These were divided into 2 groups women undergoing repeat or first CSs Specimens were collected from the LUS and were evaluated by light microscopy and by immunohistochemistry for the morphometrical quantification of the SP and VIP fibers in the LUS The SP amount was higher in the post-CS scar while the VIP amount decreased nerve fibers contained an SP amount of up to 13 +/- 2 6 C U while nerve fibers contained a VIP amount of up to 7 +/- 1 9 C U The SP amount counts 10 +/- 1 5% of the total Bodian fibers and the ratio of the VIP is 10 +/- 1 8% of their total amount In normal conditions only 661 C U of the Bodian surface is occupied by SP related nerve fibers in contrast to 663 C U of the total surface by VIP the amount of SP increased up to 13 +/- 2 6 C U while it decreased in the LUS previous scars The SP levels are higher in repeat CS while the VIP levels are reduced in the LUS The Increase of SP is probably linked to the attempt to achieve cervical ripening in a post-CS LUS with the possible consequences of dystocia during vaginal birth after CS Nevertheless the decrease of VIP probably affects the relaxation of the internal uterine orifice compromising the LUS formation and cervical ripening
2010
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/794898
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