Despite a constant improvement in manufacturing and purification technologies, hyaluronic acid dermal fillers continue to be the cause of adverse effects. The injection site reactions are the most frequent not immune-mediated side effect. They are often related to technical mistakes during the treatment. Although there are not differences in hyaluronic acid chemical composition among various tissues or species, some cases of immune-mediated adverse reactions have been reported. The most common is the appearance of foreign body granulomas. It is still unclear if these reactions are due to the hyaluronic acid molecule itself, to the presence of impurities resulting from production processes, or to degradation products of the hyaluronic acid molecule. Viscoderm® is a hyaluronic acid produced by fermentation from streptococcus. In the years 2006-2011 it was created a monitoring system designed to detect any adverse reaction due to the treatment with Viscoderm® that was not reported in the product data sheet. It was performed in 4 european countries (Italy, Great Britain, Germany, France), submitting patients to a 6-years follow up. There have been not reported side effects not listed in the data sheet.
Efficacia e sicurezza dell’acido ialuronico in dermocosmesi: il “caso” Viscoderm®
BIANCHI, LEONARDO;LISI, Paolo
2011
Abstract
Despite a constant improvement in manufacturing and purification technologies, hyaluronic acid dermal fillers continue to be the cause of adverse effects. The injection site reactions are the most frequent not immune-mediated side effect. They are often related to technical mistakes during the treatment. Although there are not differences in hyaluronic acid chemical composition among various tissues or species, some cases of immune-mediated adverse reactions have been reported. The most common is the appearance of foreign body granulomas. It is still unclear if these reactions are due to the hyaluronic acid molecule itself, to the presence of impurities resulting from production processes, or to degradation products of the hyaluronic acid molecule. Viscoderm® is a hyaluronic acid produced by fermentation from streptococcus. In the years 2006-2011 it was created a monitoring system designed to detect any adverse reaction due to the treatment with Viscoderm® that was not reported in the product data sheet. It was performed in 4 european countries (Italy, Great Britain, Germany, France), submitting patients to a 6-years follow up. There have been not reported side effects not listed in the data sheet.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
