A series of disubstituted thiazole, functionalized with the essential 3,5-dihydroxy-6-heptenoic or heptanoic chain, were prepared and evaluated in vitro as HMG-CoA reductase inhibitors. All the synthesized compounds showed a moderate inhibitory potency.

7-(Disubstituted thiazolyl)-3,5-dihydroxy-6-heptenoic/heptanoic acid derivatives as HMG-COa reductase inhibitors

CECCHETTI, Violetta;FRAVOLINI, Arnaldo;TABARRINI, Oriana;TEMPERINI, Andrea
1994

Abstract

A series of disubstituted thiazole, functionalized with the essential 3,5-dihydroxy-6-heptenoic or heptanoic chain, were prepared and evaluated in vitro as HMG-CoA reductase inhibitors. All the synthesized compounds showed a moderate inhibitory potency.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/909524
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