A series of disubstituted thiazole, functionalized with the essential 3,5-dihydroxy-6-heptenoic or heptanoic chain, were prepared and evaluated in vitro as HMG-CoA reductase inhibitors. All the synthesized compounds showed a moderate inhibitory potency.
7-(Disubstituted thiazolyl)-3,5-dihydroxy-6-heptenoic/heptanoic acid derivatives as HMG-COa reductase inhibitors
CECCHETTI, Violetta;FRAVOLINI, Arnaldo;TABARRINI, Oriana;TEMPERINI, Andrea
1994
Abstract
A series of disubstituted thiazole, functionalized with the essential 3,5-dihydroxy-6-heptenoic or heptanoic chain, were prepared and evaluated in vitro as HMG-CoA reductase inhibitors. All the synthesized compounds showed a moderate inhibitory potency.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
