1. The labelled phosphate and cytidine-diphosphate esters of choline and ethanolamine, together with their bases, were incubated with rat liver homogenate and microsomal membranes, and the transfer of radioactivity into water-soluble and lipid components examined. 2. Very little conversion of choline into betaine and phosphorylcholine, and of ethanolamine into phosphorylethanolamine, as well as into their intermediates and lipid material, was observed in both preparations. 3. Small transfer of phosphorylcholine to cytidine-diphosphate choline and to lecithin, and of phosphorylethanolamine to cytidine-diphosphate ethanolamine and phosphatidylethanolamine was observed. 4. Despite a considerable breakdown to hydrosoluble products, the two cytidinediphosphate esters were noticeably converted into corresponding phospholipid with both homogenate and microsomes.
The metabolism of phosphoric esters and of cytidine-diphosphate esters of choline and ethanolamine in the liver
BINAGLIA, Luciano;ROBERTI, Rita;PORCELLATI, Giuseppe
1973
Abstract
1. The labelled phosphate and cytidine-diphosphate esters of choline and ethanolamine, together with their bases, were incubated with rat liver homogenate and microsomal membranes, and the transfer of radioactivity into water-soluble and lipid components examined. 2. Very little conversion of choline into betaine and phosphorylcholine, and of ethanolamine into phosphorylethanolamine, as well as into their intermediates and lipid material, was observed in both preparations. 3. Small transfer of phosphorylcholine to cytidine-diphosphate choline and to lecithin, and of phosphorylethanolamine to cytidine-diphosphate ethanolamine and phosphatidylethanolamine was observed. 4. Despite a considerable breakdown to hydrosoluble products, the two cytidinediphosphate esters were noticeably converted into corresponding phospholipid with both homogenate and microsomes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
