Dirhodium(II) tetraacetate catalyzed decomposition of ethyl diazoacetate in the presence of D-Cbz-vinylglycine methyl ester (11) afforded a mixture of the cyclopropyl esters D-CGA A-D(13) from which the corresponding 2R-acids 7-10 were obtained and their absolute configurations assigned. The (2R,3S,4R) α-(carboxycyclopropyl)glycine (D-CGA C, 9 resulted to be the most potent and selective among the NMDAreceptorligands yet reported.

D-3,4-CYCLOPROPYLGLUTAMATE ISOMERS AS NMDA RECEPTOR LIGANDS - SYNTHESIS AND ENANTIOSELECTIVE ACTIVITY

PELLICCIARI, Roberto;NATALINI, Benedetto;MARINOZZI, Maura;
1990

Abstract

Dirhodium(II) tetraacetate catalyzed decomposition of ethyl diazoacetate in the presence of D-Cbz-vinylglycine methyl ester (11) afforded a mixture of the cyclopropyl esters D-CGA A-D(13) from which the corresponding 2R-acids 7-10 were obtained and their absolute configurations assigned. The (2R,3S,4R) α-(carboxycyclopropyl)glycine (D-CGA C, 9 resulted to be the most potent and selective among the NMDAreceptorligands yet reported.
1990
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/914403
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