The ability of phosphorylcholine and CDP-choline to act as lipid precursors was tested in chick brain microsomes (plus supernatant). CDP-choline was, in every case, a much better precursor of choline glycerophospholipids than phosphorylcholine. The cytìdylyltransferase reaction which forms CDP-choline appears, therefore, as the limiting step of the metabolic pathway which introduces phosphorylcholine into lipids. This reaction can be stimulated by the addition of phospholipids to the incubation mixture. Choline lysoglycerophospholipids are the most active in this connection. I

Involvement of CDP-choline in phospholipid metabolism of brain tissue in vitro

ARIENTI, Giuseppe;CORAZZI, Lanfranco;PORCELLATI, Giuseppe
1979

Abstract

The ability of phosphorylcholine and CDP-choline to act as lipid precursors was tested in chick brain microsomes (plus supernatant). CDP-choline was, in every case, a much better precursor of choline glycerophospholipids than phosphorylcholine. The cytìdylyltransferase reaction which forms CDP-choline appears, therefore, as the limiting step of the metabolic pathway which introduces phosphorylcholine into lipids. This reaction can be stimulated by the addition of phospholipids to the incubation mixture. Choline lysoglycerophospholipids are the most active in this connection. I
1979
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/914541
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact