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Anagrafe della Ricerca dell'Università degli Studi di Perugia.
EnglishBackground: BRAF inhibitors such as vemurafenib are a new family of biological drugs, recently available to treat metastatic malignant melanoma.Methods: We present the case of a 38-year-old man affected by metastatic melanoma who had been under treatment with vemurafenib for a few days. The patient suffered from sudden onset of abdominal pain due to intra-abdominal hemorrhage with profuse hemoperitoneum. An emergency abdominal sonography confirmed the clinical suspicion of a splenic rupture.Results: The intraoperative finding was hemoperitoneum due to splenic two-step rupture and splenectomy was therefore performed. Histopathology confirmed splenic hematoma and capsule laceration, in the absence of metastasis.Conclusions: This report describes the occurrence of a previously unreported adverse event in a patient with stage IV melanoma receiving vemurafenib.
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| Titolo: | Spontaneous splenic rupture in patient with metastatic melanoma treated with Vemurafenib |
| Autori: | |
| Data di pubblicazione: | 2012 |
| Rivista: | |
| Abstract: | Background: BRAF inhibitors such as vemurafenib are a new family of biological drugs, recently available to treat metastatic malignant melanoma.Methods: We present the case of a 38-year-old man affected by metastatic melanoma who had been under treatment with vemurafenib for a few days. The patient suffered from sudden onset of abdominal pain due to intra-abdominal hemorrhage with profuse hemoperitoneum. An emergency abdominal sonography confirmed the clinical suspicion of a splenic rupture.Results: The intraoperative finding was hemoperitoneum due to splenic two-step rupture and splenectomy was therefore performed. Histopathology confirmed splenic hematoma and capsule laceration, in the absence of metastasis.Conclusions: This report describes the occurrence of a previously unreported adverse event in a patient with stage IV melanoma receiving vemurafenib. |
| Handle: | http://hdl.handle.net/11391/917580 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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