A series of azole derivatives of 1,4-benzothiazine 7-14 was synthesized and evaluated for the in vitro and in vivo activity against Candida albicans. Secondary alcohol 10 and its ether derivative 13 showed very good efficacy against systemic candidiasis in a murine experimental model.
Azole derivatives of 1,4 benzothiazine as antifungal agents.
FRINGUELLI, Renata;SCHIAFFELLA, Fausto;BISTONI, Francesco;PITZURRA, Lucia;VECCHIARELLI, Anna
1998
Abstract
A series of azole derivatives of 1,4-benzothiazine 7-14 was synthesized and evaluated for the in vitro and in vivo activity against Candida albicans. Secondary alcohol 10 and its ether derivative 13 showed very good efficacy against systemic candidiasis in a murine experimental model.File in questo prodotto:
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