The aim of the work was to address the variables impacting micronization of capreomycin sulfate (Cp), to obtain an inhalable dry powder using a Buchi Nano Spray-dryer B-90. Bacitracin was chosen as a model drug to assess the experimental design. A factorial design was chosen to minimize the number of experiments required to address the impact of inlet temperature, drug concentration (%w/v) in the feed solution, and the piezoelectric membrane pore size on the volume mean diameter (dmv), span and process yield. A statistical modeling of a drug powder spray-drying process was successful in determining the conditions allowing proper micronization of bacitracin and Cp. A potentially inhalable Cp dry powder was thereby obtained by employing a high efficiency Nano spray-dryer.
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Titolo: | Improvement of drug powder micronization by statistical modeling of a spray drying process |
Autori: | |
Data di pubblicazione: | 2012 |
Abstract: | The aim of the work was to address the variables impacting micronization of capreomycin sulfate (...Cp), to obtain an inhalable dry powder using a Buchi Nano Spray-dryer B-90. Bacitracin was chosen as a model drug to assess the experimental design. A factorial design was chosen to minimize the number of experiments required to address the impact of inlet temperature, drug concentration (%w/v) in the feed solution, and the piezoelectric membrane pore size on the volume mean diameter (dmv), span and process yield. A statistical modeling of a drug powder spray-drying process was successful in determining the conditions allowing proper micronization of bacitracin and Cp. A potentially inhalable Cp dry powder was thereby obtained by employing a high efficiency Nano spray-dryer. |
Handle: | http://hdl.handle.net/11391/917971 |
Appare nelle tipologie: | 4.2 Abstract in Atti di convegno |