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Anagrafe della Ricerca dell'Università degli Studi di Perugia.
EnglishThe aim of the work was to address the variables impacting micronization of capreomycin sulfate (Cp), to obtain an inhalable dry powder using a Buchi Nano Spray-dryer B-90. Bacitracin was chosen as a model drug to assess the experimental design. A factorial design was chosen to minimize the number of experiments required to address the impact of inlet temperature, drug concentration (%w/v) in the feed solution, and the piezoelectric membrane pore size on the volume mean diameter (dmv), span and process yield. A statistical modeling of a drug powder spray-drying process was successful in determining the conditions allowing proper micronization of bacitracin and Cp. A potentially inhalable Cp dry powder was thereby obtained by employing a high efficiency Nano spray-dryer.
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| Titolo: | Improvement of drug powder micronization by statistical modeling of a spray drying process |
| Autori: | |
| Data di pubblicazione: | 2012 |
| Abstract: | The aim of the work was to address the variables impacting micronization of capreomycin sulfate (Cp), to obtain an inhalable dry powder using a Buchi Nano Spray-dryer B-90. Bacitracin was chosen as a model drug to assess the experimental design. A factorial design was chosen to minimize the number of experiments required to address the impact of inlet temperature, drug concentration (%w/v) in the feed solution, and the piezoelectric membrane pore size on the volume mean diameter (dmv), span and process yield. A statistical modeling of a drug powder spray-drying process was successful in determining the conditions allowing proper micronization of bacitracin and Cp. A potentially inhalable Cp dry powder was thereby obtained by employing a high efficiency Nano spray-dryer. |
| Handle: | http://hdl.handle.net/11391/917971 |
| Appare nelle tipologie: | 4.2 Abstract in Atti di convegno |
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