The aim of the work was to address the variables impacting micronization of capreomycin sulfate (Cp), to obtain an inhalable dry powder using a Buchi Nano Spray-dryer B-90. Bacitracin was chosen as a model drug to assess the experimental design. A factorial design was chosen to minimize the number of experiments required to address the impact of inlet temperature, drug concentration (%w/v) in the feed solution, and the piezoelectric membrane pore size on the volume mean diameter (dmv), span and process yield. A statistical modeling of a drug powder spray-drying process was successful in determining the conditions allowing proper micronization of bacitracin and Cp. A potentially inhalable Cp dry powder was thereby obtained by employing a high efficiency Nano spray-dryer.
Improvement of drug powder micronization by statistical modeling of a spray drying process
GIOVAGNOLI, Stefano;SCHOUBBEN, Aurelie Marie Madeleine;BLASI, PAOLO;RICCI, Maurizio
2012
Abstract
The aim of the work was to address the variables impacting micronization of capreomycin sulfate (Cp), to obtain an inhalable dry powder using a Buchi Nano Spray-dryer B-90. Bacitracin was chosen as a model drug to assess the experimental design. A factorial design was chosen to minimize the number of experiments required to address the impact of inlet temperature, drug concentration (%w/v) in the feed solution, and the piezoelectric membrane pore size on the volume mean diameter (dmv), span and process yield. A statistical modeling of a drug powder spray-drying process was successful in determining the conditions allowing proper micronization of bacitracin and Cp. A potentially inhalable Cp dry powder was thereby obtained by employing a high efficiency Nano spray-dryer.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
