Carbon Tetrachloride-Induced Experimental Cirrhosis in the Rat: A Reappraisal of the Model

Ariosto, F.; Riggio, O.; Cantafora, A.; Colucci, S.; Gaudio, E.; Mechelli, Luca; Merli, M.; Capocaccia, L.

doi:10.1159/000129038

The goal of this study was to evaluate the presence of extrahepatic damage and the uniformity and reversibility of the histological findings in CCl4.induced liver cirrhosis in the rat. To verify these findings rats were sacrificed 2 and 10 weeks after a treatment consisting of ten intragastric doses of CCl4, administered weekly. All treated rats developed an irreversible micronodular cirrhosis with no damage to the brain, kidney and pancreas. Moreover, rats sacrificed 2 weeks after the last CCl4 dose showed a number of functional alterations usually observed in man. In particular, low branched chain/aromatic amino acids (BCAA/AAA) plasma ratio, high ammonia, low zinc and high insulin with normal blood glucose were obtained.

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Titolo:	Carbon Tetrachloride-Induced Experimental Cirrhosis in the Rat: A Reappraisal of the Model
Autori:	F. Ariosto O. Riggio A. Cantafora S. Colucci E. Gaudio MECHELLI, Luca M. Merli L. Capocaccia mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1989
Rivista:	EUROPEAN SURGICAL RESEARCH
Abstract:	The goal of this study was to evaluate the presence of extrahepatic damage and the uniformity and reversibility of the histological findings in CCl4.induced liver cirrhosis in the rat. To verify these findings rats were sacrificed 2 and 10 weeks after a treatment consisting of ten intragastric doses of CCl4, administered weekly. All treated rats developed an irreversible micronodular cirrhosis with no damage to the brain, kidney and pancreas. Moreover, rats sacrificed 2 weeks after the last CCl4 dose showed a number of functional alterations usually observed in man. In particular, low branched chain/aromatic amino acids (BCAA/AAA) plasma ratio, high ammonia, low zinc and high insulin with normal blood glucose were obtained.
Handle:	http://hdl.handle.net/11391/918246
Appare nelle tipologie:	1.1 Articolo in rivista

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