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EnglishA cytochemical study was carried out on adenylate cyclase (AC) activity in the early human placenta. Samples of placental villi were incubated in a medium containing adenylyl-imidodiphosphate (AMP-PNP) as specific substrate. No AC reaction product was encountered in placenta villi taken at 5 and 7 weeks of pregnancy. AC activity appeared at 9 weeks. At 9 and 10 weeks, AC reaction product was localized on the basal plasma membranes and on apposed plasma membranes of the Langhans cytotrophoblast. At 11 weeks AC activity was also clearly visible on Langhans cytotrophoblast and syncytiotrophoblast apposed plasma membranes. No AC reaction product was ever detected on the syncytiotrophoblast microvillar membrane. These results are in agreement with biochemical studies that localize AC on the villous trophoblast plasma membranes associated with the fetal circulation.
Ultracytochemical localization of adenylate cyclase in early human placenta. / Spreca A; Rambotti MG; Ferrarese R; Pomili G; Angelini A.. - In: THE ANATOMICAL RECORD. - ISSN 0003-276X. - 220(1988), pp. 388-392.
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| Titolo: | Ultracytochemical localization of adenylate cyclase in early human placenta. | |
| Autori: | ||
| Data di pubblicazione: | 1988 | |
| Rivista: | ||
| Citazione: | Ultracytochemical localization of adenylate cyclase in early human placenta. / Spreca A; Rambotti MG; Ferrarese R; Pomili G; Angelini A.. - In: THE ANATOMICAL RECORD. - ISSN 0003-276X. - 220(1988), pp. 388-392. | |
| Abstract: | A cytochemical study was carried out on adenylate cyclase (AC) activity in the early human placen...ta. Samples of placental villi were incubated in a medium containing adenylyl-imidodiphosphate (AMP-PNP) as specific substrate. No AC reaction product was encountered in placenta villi taken at 5 and 7 weeks of pregnancy. AC activity appeared at 9 weeks. At 9 and 10 weeks, AC reaction product was localized on the basal plasma membranes and on apposed plasma membranes of the Langhans cytotrophoblast. At 11 weeks AC activity was also clearly visible on Langhans cytotrophoblast and syncytiotrophoblast apposed plasma membranes. No AC reaction product was ever detected on the syncytiotrophoblast microvillar membrane. These results are in agreement with biochemical studies that localize AC on the villous trophoblast plasma membranes associated with the fetal circulation. | |
| Handle: | http://hdl.handle.net/11391/918732 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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