Peptides of the constant region of antibodies display fungicidal activity

Polonelli, L; Ciociola, T; Magliani, W; Zanello, Pp; D'Adda, T; Galati, S; De Bernardis, F; Arancia, S; Gabrielli, Elena; Pericolini, Eva; Vecchiarelli, Anna; Arruda, Dc; Pinto, Mr; Travassos, Lr; Pertinhez, Ta; Spisni, A; Conti, S.

doi:10.1371/journal.pone.0034105

Synthetic peptides with sequences identical to fragments of the constant region of different classes (IgG, IgM, IgA) of antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, Candida glabrata, Cryptococcus neoformans, and Malassezia furfur, including caspofungin and triazole resistant strains. Alanine-substituted derivatives of fungicidal Fc-peptides, tested to evaluate the critical role of each residue, displayed unaltered, increased or decreased candidacidal activity in vitro. An Fc-peptide, included in all human IgGs, displayed a therapeutic effect against experimental mucosal and systemic candidiasis in mouse models. It is intriguing to hypothesize that some Fc-peptides may influence the antifungal immune response and constitute the basis for devising new antifungal agents.

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Titolo:	Peptides of the constant region of antibodies display fungicidal activity
Autori:	Polonelli L Ciociola T Magliani W Zanello PP D'Adda T Galati S De Bernardis F Arancia S GABRIELLI, ELENA PERICOLINI, Eva VECCHIARELLI, Anna Arruda DC Pinto MR Travassos LR Pertinhez TA Spisni A Conti S. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2012
Rivista:	PLOS ONE
Abstract:	Synthetic peptides with sequences identical to fragments of the constant region of different classes (IgG, IgM, IgA) of antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, Candida glabrata, Cryptococcus neoformans, and Malassezia furfur, including caspofungin and triazole resistant strains. Alanine-substituted derivatives of fungicidal Fc-peptides, tested to evaluate the critical role of each residue, displayed unaltered, increased or decreased candidacidal activity in vitro. An Fc-peptide, included in all human IgGs, displayed a therapeutic effect against experimental mucosal and systemic candidiasis in mouse models. It is intriguing to hypothesize that some Fc-peptides may influence the antifungal immune response and constitute the basis for devising new antifungal agents.
Handle:	http://hdl.handle.net/11391/919996
Appare nelle tipologie:	1.1 Articolo in rivista

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