Earlier studies have disclosed that leucinostatin A, a hydrophobic nonapeptide antibiotic, assumes and alpha-helical secondary structure in nonpolar environments. The present report demonstrated that the peptide acts as a weak ionophore facilitating the transport of mono- and divalent cations through the plasma membrane of T lymphocytes and through artificial membranes. Leucinostatin A does not change the thymidine uptake of both resting mouse thymocytes and peripheral blood lymphocytes but dose-dependently prevents the activation of T lymphocytes by tetradecanoyl-phorbol-acetate and by anti-T cell receptor antibody.
The nonapeptide leucinostatin A acts as a weak ionophore and as an immunosuppressant on lymphocytes.
ROSSI, Carlo;RICCI, Maurizio;
1994
Abstract
Earlier studies have disclosed that leucinostatin A, a hydrophobic nonapeptide antibiotic, assumes and alpha-helical secondary structure in nonpolar environments. The present report demonstrated that the peptide acts as a weak ionophore facilitating the transport of mono- and divalent cations through the plasma membrane of T lymphocytes and through artificial membranes. Leucinostatin A does not change the thymidine uptake of both resting mouse thymocytes and peripheral blood lymphocytes but dose-dependently prevents the activation of T lymphocytes by tetradecanoyl-phorbol-acetate and by anti-T cell receptor antibody.File in questo prodotto:
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