A Michael addition of racemic indanone carboxylates to vinyl selenone catalyzed by C6'-hydroxyl cinchona derivatives is the key step of a synthetic sequence for a practical access to highly enantioenriched (up to 98% ee) polycyclic pyrrolidines bearing contiguous tertiary and quaternary stereocenters.
Organocatalytic Michael addition of indanone carboxylates to vinyl selenone for the asymmetric synthesis of polycyclic pyrrolidines
STERNATIVO, Silvia;BATTISTELLI, BENEDETTA;TESTAFERRI, Lorenzo;MARINI, Francesca
2012
Abstract
A Michael addition of racemic indanone carboxylates to vinyl selenone catalyzed by C6'-hydroxyl cinchona derivatives is the key step of a synthetic sequence for a practical access to highly enantioenriched (up to 98% ee) polycyclic pyrrolidines bearing contiguous tertiary and quaternary stereocenters.File in questo prodotto:
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