In recent years, considerable progress has been made in elucidating the molecular pathogenesis of diffuse large B-cell lymphoma (DLBCL) as a clonal malignant expansion of B-cells that are trapped at distinct stages of B-cell differentiation. The development of high-resolution technologies allowing the assessment of genomic and transcriptional changes revealed the existence of multiple DLBCL subtypes characterized by distinct phenotypic features and clinical behavior. The identified molecular subgroups are associated with recurrent genetic lesions that target key signaling pathways in lymphoid maturation and differentiation, and may differentially influence treatment outcome. This chapter summarizes current knowledge about the molecular mechanisms that are responsible for the development of DLBCL, and describes how recent advances in the genomic characterization of these tumors have led to the identification of genetic lesions and cellular pathways that represent potential attractive targets for improved diagnosis and therapy.
Diffuse large B cell lymphoma
PASQUALUCCI, Laura
2013
Abstract
In recent years, considerable progress has been made in elucidating the molecular pathogenesis of diffuse large B-cell lymphoma (DLBCL) as a clonal malignant expansion of B-cells that are trapped at distinct stages of B-cell differentiation. The development of high-resolution technologies allowing the assessment of genomic and transcriptional changes revealed the existence of multiple DLBCL subtypes characterized by distinct phenotypic features and clinical behavior. The identified molecular subgroups are associated with recurrent genetic lesions that target key signaling pathways in lymphoid maturation and differentiation, and may differentially influence treatment outcome. This chapter summarizes current knowledge about the molecular mechanisms that are responsible for the development of DLBCL, and describes how recent advances in the genomic characterization of these tumors have led to the identification of genetic lesions and cellular pathways that represent potential attractive targets for improved diagnosis and therapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.