IRIS - Res&Arch Institutional Research Information System - Research & Archive

COSTANTINO, Gabriele
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 2.932
EU - Europa 2.326
AS - Asia 1.992
SA - Sud America 284
AF - Africa 45
Continente sconosciuto - Info sul continente non disponibili 3
OC - Oceania 3
Totale 7.585
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 2.874
SG - Singapore 859
UA - Ucraina 537
SE - Svezia 377
IE - Irlanda 355
RU - Federazione Russa 304
VN - Vietnam 289
HK - Hong Kong 244
CN - Cina 238
BR - Brasile 217
DE - Germania 179
IT - Italia 146
FI - Finlandia 109
KR - Corea 106
FR - Francia 100
GB - Regno Unito 80
TR - Turchia 57
IN - India 40
BE - Belgio 39
JP - Giappone 30
CA - Canada 28
BD - Bangladesh 23
PL - Polonia 22
IQ - Iraq 18
UZ - Uzbekistan 17
AR - Argentina 16
CO - Colombia 16
MX - Messico 16
ZA - Sudafrica 16
NL - Olanda 15
CZ - Repubblica Ceca 13
LB - Libano 11
EC - Ecuador 10
CH - Svizzera 9
VE - Venezuela 9
PK - Pakistan 8
AT - Austria 7
KE - Kenya 7
PY - Paraguay 7
ID - Indonesia 6
PH - Filippine 6
RO - Romania 6
LT - Lituania 5
SA - Arabia Saudita 5
DZ - Algeria 4
ES - Italia 4
GR - Grecia 4
JO - Giordania 4
MA - Marocco 4
PE - Perù 4
TH - Thailandia 4
AE - Emirati Arabi Uniti 3
AU - Australia 3
CI - Costa d'Avorio 3
EU - Europa 3
HN - Honduras 3
IL - Israele 3
KW - Kuwait 3
MY - Malesia 3
OM - Oman 3
PA - Panama 3
TN - Tunisia 3
AZ - Azerbaigian 2
BG - Bulgaria 2
BH - Bahrain 2
BO - Bolivia 2
CL - Cile 2
DK - Danimarca 2
DO - Repubblica Dominicana 2
ET - Etiopia 2
HR - Croazia 2
NG - Nigeria 2
NP - Nepal 2
PT - Portogallo 2
BB - Barbados 1
BJ - Benin 1
BN - Brunei Darussalam 1
BW - Botswana 1
BY - Bielorussia 1
CR - Costa Rica 1
CY - Cipro 1
EE - Estonia 1
EG - Egitto 1
GE - Georgia 1
GT - Guatemala 1
HU - Ungheria 1
IR - Iran 1
IS - Islanda 1
JM - Giamaica 1
KH - Cambogia 1
MD - Moldavia 1
ME - Montenegro 1
MK - Macedonia 1
PR - Porto Rico 1
SN - Senegal 1
SR - Suriname 1
TT - Trinidad e Tobago 1
TW - Taiwan 1
Totale 7.585
Salva come PNG Salva come JPEG
Città #
Singapore 551
Chandler 408
Dublin 354
Jacksonville 308
Hong Kong 240
San Jose 214
Dong Ket 211
San Mateo 200
Ashburn 151
Boardman 129
Santa Clara 112
Seoul 106
Moscow 101
Medford 85
Princeton 84
Ann Arbor 83
Lauterbourg 77
Wilmington 75
Andover 59
Beijing 57
Los Angeles 46
Altamura 43
New York 40
Izmir 39
Brussels 38
Piscataway 37
Lawrence 35
Des Moines 33
Saint Petersburg 32
Munich 30
The Dalles 30
São Paulo 27
Perugia 25
Hanoi 24
Tokyo 23
Orem 21
Ho Chi Minh City 20
Helsinki 16
Warsaw 16
Norwalk 15
Woodbridge 15
Auburn Hills 13
Boston 13
Denver 13
Chennai 12
Shanghai 12
Stockholm 12
Johannesburg 11
Turku 11
Baghdad 10
Houston 10
San Paolo di Civitate 10
West Jordan 10
Phoenix 9
Tashkent 9
Toronto 9
Brno 8
Brooklyn 8
Poplar 8
San Francisco 8
Amsterdam 7
Ankara 7
Chicago 7
Manchester 7
Montreal 7
Philadelphia 7
Rio de Janeiro 7
Dallas 6
Delhi 6
Frankfurt Am Main 6
London 6
Mexico City 6
Nairobi 6
Nuremberg 6
Quito 6
Atlanta 5
Columbus 5
Den Haag 5
Hefei 5
Ottawa 5
Amman 4
Asunción 4
Bhubaneswar 4
Bogotá 4
Bologna 4
Council Bluffs 4
Da Nang 4
Dhaka 4
Haiphong 4
Lagoa da Prata 4
Manaus 4
Mcallen 4
Mumbai 4
Olomouc 4
Pelotas 4
Redwood City 4
Riyadh 4
Rome 4
Timisoara 4
Abidjan 3
Totale 4.607
Salva come PNG Salva come JPEG
Nome #
1,4 Benzothiazine and 1,4 benzoxazine imidazole derivatives with antifungal activity: a docking study 322
1-AMINOINDAN-1,5-DICARBOXYLIC ACID - A NOVEL ANTAGONIST AT PHOSPHOLIPASE C-LINKED METABOTROPIC GLUTAMATE RECEPTORS 222
Asymmetric synthesis of (2R, 1’S, 2’R, 3’S)-2-(2’- Carboxy-3’-phenylcyclopropyl)glicine (PCCG 13), the first selective antagonist of metabotropic glutamate receptors coupled phospholipase D 177
Autocorrelation as a tool for a congruent description of molecu¬les in 3D-QSAR studies 130
Asymmetric Synthesis of Enantiomerically Pure (2S,1'S,2'S,3'R)-Phenylcarboxycyclopropylglycine (PCCG-4): a Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors 125
(2R,1’S,2’R,3’S)-2-(2’-Carboxy-3’-phenylcyclopropyl)glycine (PCCG-13), the First Potent and Selective Competitive Antagonist of Phospholipase D-Coupled Metabotropic Glutamate Receptors: Asymmetric Synthesis and Preliminary Biological Properties 123
Binding Mode of 6ECDCA, a Potent Bile Acid Agonist of the Farnesoid X Receptor (FXR) 121
Spiro[2.2]pentane as a Dissymmetric Scaffold for Conformationally Constrained Analogues of Glutamic Acid: Focus on Racemic 1-Aminospiro[2.2]pentyl-1,4-dicarboxylic Acids 118
Towards New Neuroprotective Agents: Design and Synthesis of Thieno[2,3-c]-isoquinolinon-5-one as a Potent PARP-1 Inhibitor. 117
Bulky 1,4-benzoxazine derivatives with antifungal activity 117
The aryl hydrocarbon receptor (AhR) mediates the counter-regulatory effects of pelargonidins in models of inflammation and metabolic dysfunctions 116
Spiro[2.2]pentane as a dyssymetric scaffold for conformationally constrained analogues of glutamic acid: diastereodivergent synthesis of 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids 114
Chromatographic separation and evaluation of the lipophilicity by reversed-phase high-performance liquid chromatography of fullerene-C60 derivatives 112
"*-Diazocarbonyl Chemistry - Target Driven Applications" 111
Insights into Phenylalanine Derivatives Recognition of VLA-4 Integrin: from a Pharmacophoric Study to 3D-QSAR and Molecular Docking Analyses 111
Design, Synthesis and Preliminay Evaluation of Novel 3’-Substituted Carboxycyclopropylglycines as Antagonists at Group 2 Metabotropic Glutamate Receptors 111
Metabotropic glutamate receptors: structure and new subtype-selective ligands 109
Design, Synthesis, and Microbiolgical Evaluation of New Candida albicans CYP51 Inhibitors 109
GOLPE: An Advanced Chemometric Tool for 3D-QSAR Problems 109
Discovery of a AHR pelargonidin agonist that counter-regulates Ace2 expression and attenuates ACE2-SARS-CoV-2 interaction 109
On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives. 106
Design and synthesis of 4H-thieno[2,3-c]isoquinolin-5-one derivatives as potent PARP-1 inhibitors, on route of new antiischemic agents 105
Dirhodium(II)-tetraacetate-Mediated Decomposition of Ethyldiazo- acetate and Ethyldiazomalonate in the Presence of Fullerene. A New Procedure for the Selective Synthesis of [6-6]-Closed Methanofullerenes 104
Design, Molecular Modeling Studies, Synthesis and Preliminary Evaluation of Novel PARP-1 Inhibitors on the Road of Antiischemic Agents 104
Modulators of the kynurenine pathway of triptophan metabolism. Synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylalanine, the first potent and selective kynurenine aminotransferse II (KAT II) inhibitor 103
Homology Modeling of AMPA Receptors: Route to the identification of noncompetitive antagonists binding site 101
Novel PARP Inhibitors: Synthesis and Molecular Modeling Studies 99
Binding modes of noncompetitive AMPA Antagonists: A computational approach 98
Definition of a pharmacophore for the metabotropic glutamate receptors negatively linked to adenylyl cyclase 98
S-(+)-2-(3'carboxy-bicyclo[1.1.1]pentyl)glycine, a structurally new group I metabotropic glutamate receptor antagonist 97
Synthesis, Molecular Modeling and Preliminary Biological Evaluation of 1-Amino-3-Phospono-3-Cyclopentene-1-Carboxylic acid and 1-Amino-3-Phosphono-2-Cyclopentene-1-Carboxylic acid, Two Novel Agonists of Metabotropic Glutamate Receptors of Group III 97
Rat Brain Guanosine Binding Site:Biological Studies and Pseudo Receptor Construction 94
Poly(ADP-ribose)-Polimerase-Catalyzed Hydrolysis of NAD+: QM/MM Simulation of the Enzyme Reaction 93
Rat brain guanosine binding site. Biological studies and pseudo-Receptor construction 92
Poly(ADP-ribose)-polymerase-catalyzed hydrolysis of NAD+: QM/MM simulation of the enzyme reaction. ChemMedChem. 2006 May;1(5):533-9. 89
Metabotropic Glutamate Receptors: A Structural View Point 87
Disjoint Principal Properties of Organic Substituents 87
Generating Optimal Linear PLS Estimations (GOLPE): An Advanced Chemometric Tool for Handling 3D-QSAR Problems 87
Molecular Dynamics Simulation of the Ligand Binding Domain of Farnesoid X Receptor (FXR). Insights into Helix-12 Stability and Coactivator Peptide Stabilization in Response to Agonist Binding 86
Molecular determinats for metabotropic glutamate receptor activation and blockade. Molecular dynamics and electrostatic potential analysis studies 86
Prediction ability of regression models. Part 2. Selection of the best predictive PLS model 86
Molecular dynamics simulation of the ligand binding domain of mGluR1 in response to agonist and antagonist binding. 85
Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist 84
Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase. 84
Potential Therapeutic Applications of Farnesoid X Receptor (FXR) Modulators 83
Evaluation of Hydrophobic/Hydrophilic Balance of Bile Acids by Comparative Molecular Field Analysis (CoMFA) 83
Bile Acid Derivatives as Ligands of the Farnesoid X Receptor. Synthesis, Evaluation, and Structure Activity Relationship of a Series of Body and Side Chain Modified Analogs of Chenodeoxycholic Acid 83
Metabotropic glutamate receptors: new ligands and molecular modelling studies 82
Conformational requirements for interaction of L-glutamate with the metabotropic EAA receptor 80
Pharmacophore model for bile acids recognition by the FPR receptor. 79
The Pseudoactive Site as a Tool for Indirect Drug Design. Application to Inhibitors of Kynurenine-3-hydroxylase 77
Identification of Human Alanine-Glyoxylate Aminotransferase Ligands as Pharmacological Chaperones for Variants Associated with Primary Hyperoxaluria Type 1 76
Tu1738 - The Aryl Hydrocarbon Receptor Mediates Anti-Inflammatory Activities of Natural and Synthetic Pelargonidines in Mouse Models of Colitis 76
Pharmacophore Models of Group I and Group II Metabotropic Glutamate Receptors Agonists. Analysis of Conformational, Steric and Topological Parameters Affecting Potency and Selectivity 75
Synthesis and Biological Evaluation of 2-(3’-(1H-tetrazol-5-yl)bicyclo[1.1.1]pent-1-yl)glycine (S-TBPG), a novel mGlu1 Receptor 73
MODULATION OF THE KYNURENINE PATHWAY IN SEARCH FOR NEW NEUROPROTECTIVE AGENTS - SYNTHESIS AND PRELIMINARY EVALUATION OF (M-NITROBENZOYL)ALANINE, A POTENT INHIBITOR OF KYNURENINE-3-HYDROXYLASE 72
Studies on the interaction between PARP’s catalytic site and inhibitors. Design and synthesis of new class of inhibitor derivatives 72
Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study. 71
Towards Selective PARP-2 Inhibitors: Design, Synthesis and Preliminary Evaluation of a Series of Isoquinolinone Derivatives 71
HETEROCYCLIC MODULATORS OF THE NMDA RECEPTOR 71
On the Way to Selective PARP-2 Inhibitors: Design, Synthesis and Preliminary Evaluation of a Series of Isoquinolinone Derivatives 71
Novel Isoquinoline-Derived Inhibitors of Poly(ADP-Ribose) Polymerase-1: Pharmacological Characterization and Neuroprotective Effects in an in Vitro Model of Cerebral Ischemia 71
Series design 68
Synthesis and Prelyminary Pharmacological Evaluation of the Four Stereoisomers of (2S)-2-(2’-Phosphono-3’-phenylcyclopropyl)glycine, the First Stereolibrary of trans 3’- Substituted -2-(2’-Phosphonocyclopropyl) glycine 67
Docking studies on PARP-1 inhibitors: insights into the role of a binding pocket water molecole. 67
Synthesis, preliminary evaluation and molecular modeling studies of new, conformationally constrained analogues of the competitive NMDA receptor antagonist 4-(phosphonomethyl)-2-piperidinecarboxylic acid (CGS 19755) 66
SYNTHESIS AND BIOLOGICAL EVALUATION OF 6-CARBOXY-3,4-METHANOPROLINES, NEW RIGID GLUTAMATE ANALOGS 66
Exploring Ligand Recognition in the Kynurenine Pathway to Advance the Medicinal Chemistry of Kynurenines 66
Stereoselective Synthesis and Preliminary Evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): Identification of (+)-3-MATIDA as a Novel mGluR1 Competitive Antagonist 65
Kynurenine-3-hydroxylase and its selective inhibitors. Molecular modeling studies. 65
Farnesoid X receptor: from structure to potential clinical applications. 64
Prediction ability of regression models. Part 1. Standard deviation of prediction errors (SDEP) 63
Studies guanosine binding sites in rat brain: S.A.R. analysis and pharmacophore design 62
Synthesis of 6,6-dicarboxy-3,4-methano-L-proline, a new constrained glutamate analog endowed with neuroprotective properties 62
Exploring the Molecular Dasis of the Selectivity in Metabotropic Glutamate Receptors (mGluRs) 62
Metabotropic Glutamate Receptors: Targets for Therapy of Cerebral Ischemia 60
Homology Model of the Closed, Functionally Active, Form of the Amino Terminal Domain of mGluR1 60
Synthesis and biological evaluation of (2S)- and (2R)-2-(3'-phosphonobicyclo[1.1.1]pentyl)glycines as novel group III selective metabotropic glutamate receptor ligands. 59
Synthesis and Preliminary Biological Evaluation of glycineb site (+)- and (-)-3-Oxetanylglycine, Novel non-Proteinogenic Amino Acids 58
New potent and selective mGluR1 competitive antagonists: pharmacological characterization and their exploitation in molecular modeling of receptor blocking 57
Homology Model of the Multidrag transporter LmrA from Lactococcus Lactis 56
PARP-1 and its inhibitors: molecular modeling studies 53
Modulation of glutamate receptor pathways in the search for new neuroprotective agents 52
Synthesis and Preliminary Biological Evaluation of (2S,1’R,2’S)- and (2S,1’S,2’R)-2-(2Phosphonocyclopropyl)glycines, Two novel Conformationally Constrained L-AP4 Analogues 51
Synthesis and preliminary biological evaluation of (2S, 1'R, 2'S)- and (2S, 1'S,2' R)-2-(2-phosphonocyclopropyl)glycines, two novel conformationally constrained L-AP4 analogues 32
null 30
null 21
Totale 7.733
Salva come PNG Salva come JPEG
Categoria #
all - tutte 30.959
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 30.959
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021321 0 0 0 0 0 0 0 0 0 0 94 227
2021/2022765 24 136 13 77 47 4 5 241 5 12 96 105
2022/20231.245 90 145 17 94 168 135 2 65 469 2 48 10
2023/2024464 36 65 29 6 10 8 72 6 68 27 53 84
2024/20251.065 30 110 65 44 114 17 23 77 226 66 161 132
2025/20262.238 199 220 116 270 252 263 359 88 256 186 29 0
Totale 7.733