IRIS - Res&Arch Institutional Research Information System - Research & Archive

COSTANTINO, Gabriele
 Distribuzione geografica
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Continente #
NA - Nord America 2.593
EU - Europa 2.130
AS - Asia 1.629
SA - Sud America 218
AF - Africa 31
Continente sconosciuto - Info sul continente non disponibili 3
OC - Oceania 2
Totale 6.606
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Nazione #
US - Stati Uniti d'America 2.551
SG - Singapore 655
UA - Ucraina 536
SE - Svezia 377
IE - Irlanda 354
VN - Vietnam 267
HK - Hong Kong 226
RU - Federazione Russa 226
CN - Cina 208
BR - Brasile 193
DE - Germania 175
IT - Italia 137
FI - Finlandia 106
KR - Corea 106
GB - Regno Unito 74
TR - Turchia 46
BE - Belgio 39
CA - Canada 28
JP - Giappone 25
IN - India 23
PL - Polonia 20
FR - Francia 17
BD - Bangladesh 15
CZ - Repubblica Ceca 13
ZA - Sudafrica 13
NL - Olanda 12
UZ - Uzbekistan 12
CH - Svizzera 9
LB - Libano 9
MX - Messico 8
AT - Austria 7
EC - Ecuador 7
IQ - Iraq 7
AR - Argentina 6
RO - Romania 6
ES - Italia 4
GR - Grecia 4
LT - Lituania 4
PK - Pakistan 4
PY - Paraguay 4
AE - Emirati Arabi Uniti 3
CI - Costa d'Avorio 3
DZ - Algeria 3
EU - Europa 3
ID - Indonesia 3
KE - Kenya 3
MA - Marocco 3
AU - Australia 2
AZ - Azerbaigian 2
BG - Bulgaria 2
CL - Cile 2
CO - Colombia 2
DK - Danimarca 2
IL - Israele 2
JO - Giordania 2
PE - Perù 2
PT - Portogallo 2
SA - Arabia Saudita 2
TH - Thailandia 2
BB - Barbados 1
BH - Bahrain 1
BJ - Benin 1
BW - Botswana 1
CY - Cipro 1
DO - Repubblica Dominicana 1
EE - Estonia 1
EG - Egitto 1
GE - Georgia 1
GT - Guatemala 1
HU - Ungheria 1
IR - Iran 1
IS - Islanda 1
KH - Cambogia 1
KW - Kuwait 1
MD - Moldavia 1
NG - Nigeria 1
NP - Nepal 1
OM - Oman 1
PA - Panama 1
PH - Filippine 1
PR - Porto Rico 1
SN - Senegal 1
SR - Suriname 1
TN - Tunisia 1
TT - Trinidad e Tobago 1
TW - Taiwan 1
VE - Venezuela 1
Totale 6.606
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Città #
Chandler 408
Singapore 374
Dublin 353
Jacksonville 308
Hong Kong 222
Dong Ket 211
San Mateo 200
Boardman 129
Ashburn 108
Santa Clara 106
Seoul 106
Medford 85
Princeton 84
Ann Arbor 83
Wilmington 75
Moscow 70
Andover 59
Beijing 49
Los Angeles 45
Altamura 43
Izmir 39
Brussels 38
Piscataway 37
New York 36
Lawrence 35
Des Moines 33
Saint Petersburg 32
Munich 30
Perugia 25
São Paulo 25
Ho Chi Minh City 18
Tokyo 18
Norwalk 15
The Dalles 15
Woodbridge 15
Warsaw 14
Auburn Hills 13
Hanoi 13
Helsinki 13
Boston 12
Shanghai 12
Stockholm 12
Denver 11
Turku 11
Johannesburg 10
San Paolo di Civitate 10
West Jordan 10
Houston 9
Orem 9
Toronto 9
Brno 8
Brooklyn 8
Phoenix 8
Poplar 8
San Francisco 8
Chennai 7
Chicago 7
Montreal 7
Philadelphia 7
Rio de Janeiro 7
Frankfurt Am Main 6
Ankara 5
Atlanta 5
Columbus 5
Dallas 5
Den Haag 5
Hefei 5
London 5
Ottawa 5
Tashkent 5
Amsterdam 4
Baghdad 4
Bhubaneswar 4
Bologna 4
Da Nang 4
Delhi 4
Lagoa da Prata 4
Manaus 4
Manchester 4
Mcallen 4
Mexico City 4
Olomouc 4
Quito 4
Redwood City 4
San Jose 4
Timisoara 4
Abidjan 3
Campinas 3
Changsha 3
Dearborn 3
Dhaka 3
Falls Church 3
Frankfurt am Main 3
Fremont 3
Guangzhou 3
Haiphong 3
Hanover 3
Kofu 3
Milan 3
Monopoli 3
Totale 3.929
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Nome #
1,4 Benzothiazine and 1,4 benzoxazine imidazole derivatives with antifungal activity: a docking study 301
1-AMINOINDAN-1,5-DICARBOXYLIC ACID - A NOVEL ANTAGONIST AT PHOSPHOLIPASE C-LINKED METABOTROPIC GLUTAMATE RECEPTORS 205
Asymmetric synthesis of (2R, 1’S, 2’R, 3’S)-2-(2’- Carboxy-3’-phenylcyclopropyl)glicine (PCCG 13), the first selective antagonist of metabotropic glutamate receptors coupled phospholipase D 136
Asymmetric Synthesis of Enantiomerically Pure (2S,1'S,2'S,3'R)-Phenylcarboxycyclopropylglycine (PCCG-4): a Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors 115
Autocorrelation as a tool for a congruent description of molecu¬les in 3D-QSAR studies 112
(2R,1’S,2’R,3’S)-2-(2’-Carboxy-3’-phenylcyclopropyl)glycine (PCCG-13), the First Potent and Selective Competitive Antagonist of Phospholipase D-Coupled Metabotropic Glutamate Receptors: Asymmetric Synthesis and Preliminary Biological Properties 111
Towards New Neuroprotective Agents: Design and Synthesis of Thieno[2,3-c]-isoquinolinon-5-one as a Potent PARP-1 Inhibitor. 106
Chromatographic separation and evaluation of the lipophilicity by reversed-phase high-performance liquid chromatography of fullerene-C60 derivatives 104
Binding Mode of 6ECDCA, a Potent Bile Acid Agonist of the Farnesoid X Receptor (FXR) 102
Spiro[2.2]pentane as a dyssymetric scaffold for conformationally constrained analogues of glutamic acid: diastereodivergent synthesis of 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids 102
Design, Synthesis and Preliminay Evaluation of Novel 3’-Substituted Carboxycyclopropylglycines as Antagonists at Group 2 Metabotropic Glutamate Receptors 100
Spiro[2.2]pentane as a Dissymmetric Scaffold for Conformationally Constrained Analogues of Glutamic Acid: Focus on Racemic 1-Aminospiro[2.2]pentyl-1,4-dicarboxylic Acids 100
"*-Diazocarbonyl Chemistry - Target Driven Applications" 99
On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives. 99
Bulky 1,4-benzoxazine derivatives with antifungal activity 99
Metabotropic glutamate receptors: structure and new subtype-selective ligands 95
The aryl hydrocarbon receptor (AhR) mediates the counter-regulatory effects of pelargonidins in models of inflammation and metabolic dysfunctions 95
Synthesis, Molecular Modeling and Preliminary Biological Evaluation of 1-Amino-3-Phospono-3-Cyclopentene-1-Carboxylic acid and 1-Amino-3-Phosphono-2-Cyclopentene-1-Carboxylic acid, Two Novel Agonists of Metabotropic Glutamate Receptors of Group III 94
Design and synthesis of 4H-thieno[2,3-c]isoquinolin-5-one derivatives as potent PARP-1 inhibitors, on route of new antiischemic agents 94
Design, Synthesis, and Microbiolgical Evaluation of New Candida albicans CYP51 Inhibitors 93
GOLPE: An Advanced Chemometric Tool for 3D-QSAR Problems 93
Insights into Phenylalanine Derivatives Recognition of VLA-4 Integrin: from a Pharmacophoric Study to 3D-QSAR and Molecular Docking Analyses 92
Novel PARP Inhibitors: Synthesis and Molecular Modeling Studies 91
Design, Molecular Modeling Studies, Synthesis and Preliminary Evaluation of Novel PARP-1 Inhibitors on the Road of Antiischemic Agents 91
Dirhodium(II)-tetraacetate-Mediated Decomposition of Ethyldiazo- acetate and Ethyldiazomalonate in the Presence of Fullerene. A New Procedure for the Selective Synthesis of [6-6]-Closed Methanofullerenes 90
Discovery of a AHR pelargonidin agonist that counter-regulates Ace2 expression and attenuates ACE2-SARS-CoV-2 interaction 90
S-(+)-2-(3'carboxy-bicyclo[1.1.1]pentyl)glycine, a structurally new group I metabotropic glutamate receptor antagonist 88
Homology Modeling of AMPA Receptors: Route to the identification of noncompetitive antagonists binding site 88
Poly(ADP-ribose)-Polimerase-Catalyzed Hydrolysis of NAD+: QM/MM Simulation of the Enzyme Reaction 86
Rat Brain Guanosine Binding Site:Biological Studies and Pseudo Receptor Construction 86
Modulators of the kynurenine pathway of triptophan metabolism. Synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylalanine, the first potent and selective kynurenine aminotransferse II (KAT II) inhibitor 86
Poly(ADP-ribose)-polymerase-catalyzed hydrolysis of NAD+: QM/MM simulation of the enzyme reaction. ChemMedChem. 2006 May;1(5):533-9. 85
Binding modes of noncompetitive AMPA Antagonists: A computational approach 85
Metabotropic Glutamate Receptors: A Structural View Point 83
Generating Optimal Linear PLS Estimations (GOLPE): An Advanced Chemometric Tool for Handling 3D-QSAR Problems 81
Definition of a pharmacophore for the metabotropic glutamate receptors negatively linked to adenylyl cyclase 78
Prediction ability of regression models. Part 2. Selection of the best predictive PLS model 78
Disjoint Principal Properties of Organic Substituents 76
Pharmacophore model for bile acids recognition by the FPR receptor. 74
Rat brain guanosine binding site. Biological studies and pseudo-Receptor construction 74
Potential Therapeutic Applications of Farnesoid X Receptor (FXR) Modulators 71
Molecular dynamics simulation of the ligand binding domain of mGluR1 in response to agonist and antagonist binding. 71
Conformational requirements for interaction of L-glutamate with the metabotropic EAA receptor 71
Molecular Dynamics Simulation of the Ligand Binding Domain of Farnesoid X Receptor (FXR). Insights into Helix-12 Stability and Coactivator Peptide Stabilization in Response to Agonist Binding 70
Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist 69
Molecular determinats for metabotropic glutamate receptor activation and blockade. Molecular dynamics and electrostatic potential analysis studies 69
Tu1738 - The Aryl Hydrocarbon Receptor Mediates Anti-Inflammatory Activities of Natural and Synthetic Pelargonidines in Mouse Models of Colitis 69
Evaluation of Hydrophobic/Hydrophilic Balance of Bile Acids by Comparative Molecular Field Analysis (CoMFA) 68
Bile Acid Derivatives as Ligands of the Farnesoid X Receptor. Synthesis, Evaluation, and Structure Activity Relationship of a Series of Body and Side Chain Modified Analogs of Chenodeoxycholic Acid 68
Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study. 67
Pharmacophore Models of Group I and Group II Metabotropic Glutamate Receptors Agonists. Analysis of Conformational, Steric and Topological Parameters Affecting Potency and Selectivity 67
Synthesis and Biological Evaluation of 2-(3’-(1H-tetrazol-5-yl)bicyclo[1.1.1]pent-1-yl)glycine (S-TBPG), a novel mGlu1 Receptor 67
The Pseudoactive Site as a Tool for Indirect Drug Design. Application to Inhibitors of Kynurenine-3-hydroxylase 66
Metabotropic glutamate receptors: new ligands and molecular modelling studies 66
Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase. 65
MODULATION OF THE KYNURENINE PATHWAY IN SEARCH FOR NEW NEUROPROTECTIVE AGENTS - SYNTHESIS AND PRELIMINARY EVALUATION OF (M-NITROBENZOYL)ALANINE, A POTENT INHIBITOR OF KYNURENINE-3-HYDROXYLASE 62
Series design 62
Identification of Human Alanine-Glyoxylate Aminotransferase Ligands as Pharmacological Chaperones for Variants Associated with Primary Hyperoxaluria Type 1 61
Stereoselective Synthesis and Preliminary Evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): Identification of (+)-3-MATIDA as a Novel mGluR1 Competitive Antagonist 61
HETEROCYCLIC MODULATORS OF THE NMDA RECEPTOR 61
Docking studies on PARP-1 inhibitors: insights into the role of a binding pocket water molecole. 60
Towards Selective PARP-2 Inhibitors: Design, Synthesis and Preliminary Evaluation of a Series of Isoquinolinone Derivatives 60
SYNTHESIS AND BIOLOGICAL EVALUATION OF 6-CARBOXY-3,4-METHANOPROLINES, NEW RIGID GLUTAMATE ANALOGS 60
Studies on the interaction between PARP’s catalytic site and inhibitors. Design and synthesis of new class of inhibitor derivatives 60
Prediction ability of regression models. Part 1. Standard deviation of prediction errors (SDEP) 60
Novel Isoquinoline-Derived Inhibitors of Poly(ADP-Ribose) Polymerase-1: Pharmacological Characterization and Neuroprotective Effects in an in Vitro Model of Cerebral Ischemia 60
Studies guanosine binding sites in rat brain: S.A.R. analysis and pharmacophore design 58
On the Way to Selective PARP-2 Inhibitors: Design, Synthesis and Preliminary Evaluation of a Series of Isoquinolinone Derivatives 58
Synthesis and Prelyminary Pharmacological Evaluation of the Four Stereoisomers of (2S)-2-(2’-Phosphono-3’-phenylcyclopropyl)glycine, the First Stereolibrary of trans 3’- Substituted -2-(2’-Phosphonocyclopropyl) glycine 57
Exploring the Molecular Dasis of the Selectivity in Metabotropic Glutamate Receptors (mGluRs) 57
Metabotropic Glutamate Receptors: Targets for Therapy of Cerebral Ischemia 55
Synthesis of 6,6-dicarboxy-3,4-methano-L-proline, a new constrained glutamate analog endowed with neuroprotective properties 55
Homology Model of the Closed, Functionally Active, Form of the Amino Terminal Domain of mGluR1 54
Synthesis, preliminary evaluation and molecular modeling studies of new, conformationally constrained analogues of the competitive NMDA receptor antagonist 4-(phosphonomethyl)-2-piperidinecarboxylic acid (CGS 19755) 53
Homology Model of the Multidrag transporter LmrA from Lactococcus Lactis 52
Kynurenine-3-hydroxylase and its selective inhibitors. Molecular modeling studies. 52
Farnesoid X receptor: from structure to potential clinical applications. 52
Synthesis and Preliminary Biological Evaluation of glycineb site (+)- and (-)-3-Oxetanylglycine, Novel non-Proteinogenic Amino Acids 50
Synthesis and biological evaluation of (2S)- and (2R)-2-(3'-phosphonobicyclo[1.1.1]pentyl)glycines as novel group III selective metabotropic glutamate receptor ligands. 49
New potent and selective mGluR1 competitive antagonists: pharmacological characterization and their exploitation in molecular modeling of receptor blocking 49
Exploring Ligand Recognition in the Kynurenine Pathway to Advance the Medicinal Chemistry of Kynurenines 49
PARP-1 and its inhibitors: molecular modeling studies 44
Modulation of glutamate receptor pathways in the search for new neuroprotective agents 43
Synthesis and Preliminary Biological Evaluation of (2S,1’R,2’S)- and (2S,1’S,2’R)-2-(2Phosphonocyclopropyl)glycines, Two novel Conformationally Constrained L-AP4 Analogues 42
null 30
Synthesis and preliminary biological evaluation of (2S, 1'R, 2'S)- and (2S, 1'S,2' R)-2-(2-phosphonocyclopropyl)glycines, two novel conformationally constrained L-AP4 analogues 26
null 21
Totale 6.754
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Categoria #
all - tutte 28.376
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 28.376
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021629 0 0 0 0 0 60 85 3 122 38 94 227
2021/2022765 24 136 13 77 47 4 5 241 5 12 96 105
2022/20231.245 90 145 17 94 168 135 2 65 469 2 48 10
2023/2024464 36 65 29 6 10 8 72 6 68 27 53 84
2024/20251.065 30 110 65 44 114 17 23 77 226 66 161 132
2025/20261.259 199 220 116 270 252 202 0 0 0 0 0 0
Totale 6.754