IRIS - Res&Arch Institutional Research Information System - Research & Archive

COSTANTINO, Gabriele
 Distribuzione geografica
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Continente #
NA - Nord America 2.116
EU - Europa 1.842
AS - Asia 670
AF - Africa 4
Continente sconosciuto - Info sul continente non disponibili 3
OC - Oceania 1
Totale 4.636
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Nazione #
US - Stati Uniti d'America 2.112
UA - Ucraina 533
SE - Svezia 367
IE - Irlanda 353
VN - Vietnam 211
SG - Singapore 181
DE - Germania 140
HK - Hong Kong 126
IT - Italia 116
FI - Finlandia 94
RU - Federazione Russa 92
CN - Cina 57
GB - Regno Unito 49
TR - Turchia 41
BE - Belgio 34
KR - Corea 20
FR - Francia 14
CZ - Repubblica Ceca 10
JP - Giappone 10
LB - Libano 9
CH - Svizzera 8
NL - Olanda 8
UZ - Uzbekistan 7
RO - Romania 6
IN - India 5
PL - Polonia 5
AT - Austria 4
CA - Canada 3
CI - Costa d'Avorio 3
EU - Europa 3
GR - Grecia 3
BD - Bangladesh 2
BG - Bulgaria 2
DK - Danimarca 2
AU - Australia 1
HU - Ungheria 1
MX - Messico 1
NG - Nigeria 1
PT - Portogallo 1
TW - Taiwan 1
Totale 4.636
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Città #
Chandler 408
Dublin 352
Jacksonville 307
Dong Ket 211
San Mateo 200
Singapore 140
Boardman 129
Hong Kong 122
Santa Clara 98
Medford 85
Princeton 84
Ann Arbor 83
Wilmington 75
Andover 59
Altamura 43
Izmir 39
Lawrence 35
Brussels 33
Des Moines 33
Saint Petersburg 32
Beijing 27
Seoul 20
Perugia 16
Ashburn 15
Norwalk 15
Woodbridge 15
Auburn Hills 13
Los Angeles 13
Helsinki 12
New York 11
San Paolo di Civitate 10
Shanghai 10
West Jordan 10
Brno 8
Philadelphia 7
Frankfurt Am Main 6
Tokyo 6
Den Haag 5
Moscow 5
Mcallen 4
Redwood City 4
Timisoara 4
Abidjan 3
Bhubaneswar 3
Chicago 3
Dearborn 3
Falls Church 3
Fremont 3
Hanover 3
Monopoli 3
Munich 3
Redmond 3
Roji 3
San Diego 3
Alameda 2
Bologna 2
Bordeaux 2
Bridgewater 2
Copenhagen 2
Dallas 2
Delhi 2
Dhaka 2
Leawood 2
Milan 2
Ottawa 2
Parma 2
Rome 2
Romola 2
San Jose 2
Sanayi 2
Simi Valley 2
Stockholm 2
Tappahannock 2
Verona 2
Amsterdam 1
Baotou 1
Beirã 1
Berlin 1
Boydton 1
Budapest 1
Central 1
Chang-hua 1
Cork 1
Dartford 1
Dongguan 1
Falkenstein 1
Florence 1
Gent 1
Guangdong 1
Hertford 1
Hockessin 1
Houston 1
Kunming 1
Lagos 1
Lappeenranta 1
Lausanne 1
Livorno 1
Melbourne 1
Montreal 1
Nantong 1
Totale 2.906
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Nome #
1,4 Benzothiazine and 1,4 benzoxazine imidazole derivatives with antifungal activity: a docking study 243
1-AMINOINDAN-1,5-DICARBOXYLIC ACID - A NOVEL ANTAGONIST AT PHOSPHOLIPASE C-LINKED METABOTROPIC GLUTAMATE RECEPTORS 175
Asymmetric synthesis of (2R, 1’S, 2’R, 3’S)-2-(2’- Carboxy-3’-phenylcyclopropyl)glicine (PCCG 13), the first selective antagonist of metabotropic glutamate receptors coupled phospholipase D 100
(2R,1’S,2’R,3’S)-2-(2’-Carboxy-3’-phenylcyclopropyl)glycine (PCCG-13), the First Potent and Selective Competitive Antagonist of Phospholipase D-Coupled Metabotropic Glutamate Receptors: Asymmetric Synthesis and Preliminary Biological Properties 85
Chromatographic separation and evaluation of the lipophilicity by reversed-phase high-performance liquid chromatography of fullerene-C60 derivatives 82
Towards New Neuroprotective Agents: Design and Synthesis of Thieno[2,3-c]-isoquinolinon-5-one as a Potent PARP-1 Inhibitor. 81
Autocorrelation as a tool for a congruent description of molecu¬les in 3D-QSAR studies 81
Spiro[2.2]pentane as a Dissymmetric Scaffold for Conformationally Constrained Analogues of Glutamic Acid: Focus on Racemic 1-Aminospiro[2.2]pentyl-1,4-dicarboxylic Acids 79
Design, Synthesis and Preliminay Evaluation of Novel 3’-Substituted Carboxycyclopropylglycines as Antagonists at Group 2 Metabotropic Glutamate Receptors 78
Spiro[2.2]pentane as a dyssymetric scaffold for conformationally constrained analogues of glutamic acid: diastereodivergent synthesis of 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids 77
Novel PARP Inhibitors: Synthesis and Molecular Modeling Studies 76
The aryl hydrocarbon receptor (AhR) mediates the counter-regulatory effects of pelargonidins in models of inflammation and metabolic dysfunctions 76
Design and synthesis of 4H-thieno[2,3-c]isoquinolin-5-one derivatives as potent PARP-1 inhibitors, on route of new antiischemic agents 75
Metabotropic glutamate receptors: structure and new subtype-selective ligands 74
Asymmetric Synthesis of Enantiomerically Pure (2S,1'S,2'S,3'R)-Phenylcarboxycyclopropylglycine (PCCG-4): a Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors 74
Synthesis, Molecular Modeling and Preliminary Biological Evaluation of 1-Amino-3-Phospono-3-Cyclopentene-1-Carboxylic acid and 1-Amino-3-Phosphono-2-Cyclopentene-1-Carboxylic acid, Two Novel Agonists of Metabotropic Glutamate Receptors of Group III 73
On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives. 73
Insights into Phenylalanine Derivatives Recognition of VLA-4 Integrin: from a Pharmacophoric Study to 3D-QSAR and Molecular Docking Analyses 72
Binding Mode of 6ECDCA, a Potent Bile Acid Agonist of the Farnesoid X Receptor (FXR) 68
Poly(ADP-ribose)-Polimerase-Catalyzed Hydrolysis of NAD+: QM/MM Simulation of the Enzyme Reaction 66
Rat Brain Guanosine Binding Site:Biological Studies and Pseudo Receptor Construction 65
Homology Modeling of AMPA Receptors: Route to the identification of noncompetitive antagonists binding site 65
Design, Synthesis, and Microbiolgical Evaluation of New Candida albicans CYP51 Inhibitors 65
Poly(ADP-ribose)-polymerase-catalyzed hydrolysis of NAD+: QM/MM simulation of the enzyme reaction. ChemMedChem. 2006 May;1(5):533-9. 64
Metabotropic Glutamate Receptors: A Structural View Point 63
S-(+)-2-(3'carboxy-bicyclo[1.1.1]pentyl)glycine, a structurally new group I metabotropic glutamate receptor antagonist 62
Bulky 1,4-benzoxazine derivatives with antifungal activity 62
Prediction ability of regression models. Part 2. Selection of the best predictive PLS model 62
Binding modes of noncompetitive AMPA Antagonists: A computational approach 60
Modulators of the kynurenine pathway of triptophan metabolism. Synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylalanine, the first potent and selective kynurenine aminotransferse II (KAT II) inhibitor 60
Dirhodium(II)-tetraacetate-Mediated Decomposition of Ethyldiazo- acetate and Ethyldiazomalonate in the Presence of Fullerene. A New Procedure for the Selective Synthesis of [6-6]-Closed Methanofullerenes 59
"*-Diazocarbonyl Chemistry - Target Driven Applications" 59
Design, Molecular Modeling Studies, Synthesis and Preliminary Evaluation of Novel PARP-1 Inhibitors on the Road of Antiischemic Agents 59
Generating Optimal Linear PLS Estimations (GOLPE): An Advanced Chemometric Tool for Handling 3D-QSAR Problems 58
Molecular dynamics simulation of the ligand binding domain of mGluR1 in response to agonist and antagonist binding. 55
GOLPE: An Advanced Chemometric Tool for 3D-QSAR Problems 53
Conformational requirements for interaction of L-glutamate with the metabotropic EAA receptor 52
Evaluation of Hydrophobic/Hydrophilic Balance of Bile Acids by Comparative Molecular Field Analysis (CoMFA) 51
Definition of a pharmacophore for the metabotropic glutamate receptors negatively linked to adenylyl cyclase 51
Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist 51
Pharmacophore Models of Group I and Group II Metabotropic Glutamate Receptors Agonists. Analysis of Conformational, Steric and Topological Parameters Affecting Potency and Selectivity 50
Disjoint Principal Properties of Organic Substituents 49
Synthesis and Biological Evaluation of 2-(3’-(1H-tetrazol-5-yl)bicyclo[1.1.1]pent-1-yl)glycine (S-TBPG), a novel mGlu1 Receptor 48
Tu1738 - The Aryl Hydrocarbon Receptor Mediates Anti-Inflammatory Activities of Natural and Synthetic Pelargonidines in Mouse Models of Colitis 48
Molecular determinats for metabotropic glutamate receptor activation and blockade. Molecular dynamics and electrostatic potential analysis studies 47
Potential Therapeutic Applications of Farnesoid X Receptor (FXR) Modulators 46
Stereoselective Synthesis and Preliminary Evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): Identification of (+)-3-MATIDA as a Novel mGluR1 Competitive Antagonist 46
SYNTHESIS AND BIOLOGICAL EVALUATION OF 6-CARBOXY-3,4-METHANOPROLINES, NEW RIGID GLUTAMATE ANALOGS 46
Studies on the interaction between PARP’s catalytic site and inhibitors. Design and synthesis of new class of inhibitor derivatives 46
Series design 46
Studies guanosine binding sites in rat brain: S.A.R. analysis and pharmacophore design 45
Docking studies on PARP-1 inhibitors: insights into the role of a binding pocket water molecole. 45
Molecular Dynamics Simulation of the Ligand Binding Domain of Farnesoid X Receptor (FXR). Insights into Helix-12 Stability and Coactivator Peptide Stabilization in Response to Agonist Binding 45
Metabotropic glutamate receptors: new ligands and molecular modelling studies 45
On the Way to Selective PARP-2 Inhibitors: Design, Synthesis and Preliminary Evaluation of a Series of Isoquinolinone Derivatives 45
Bile Acid Derivatives as Ligands of the Farnesoid X Receptor. Synthesis, Evaluation, and Structure Activity Relationship of a Series of Body and Side Chain Modified Analogs of Chenodeoxycholic Acid 45
Discovery of a AHR pelargonidin agonist that counter-regulates Ace2 expression and attenuates ACE2-SARS-CoV-2 interaction 45
Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study. 44
Pharmacophore model for bile acids recognition by the FPR receptor. 44
Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase. 44
Rat brain guanosine binding site. Biological studies and pseudo-Receptor construction 42
The Pseudoactive Site as a Tool for Indirect Drug Design. Application to Inhibitors of Kynurenine-3-hydroxylase 42
Metabotropic Glutamate Receptors: Targets for Therapy of Cerebral Ischemia 39
Synthesis and Preliminary Biological Evaluation of glycineb site (+)- and (-)-3-Oxetanylglycine, Novel non-Proteinogenic Amino Acids 39
Prediction ability of regression models. Part 1. Standard deviation of prediction errors (SDEP) 39
Homology Model of the Multidrag transporter LmrA from Lactococcus Lactis 38
Homology Model of the Closed, Functionally Active, Form of the Amino Terminal Domain of mGluR1 37
Towards Selective PARP-2 Inhibitors: Design, Synthesis and Preliminary Evaluation of a Series of Isoquinolinone Derivatives 37
Synthesis of 6,6-dicarboxy-3,4-methano-L-proline, a new constrained glutamate analog endowed with neuroprotective properties 37
MODULATION OF THE KYNURENINE PATHWAY IN SEARCH FOR NEW NEUROPROTECTIVE AGENTS - SYNTHESIS AND PRELIMINARY EVALUATION OF (M-NITROBENZOYL)ALANINE, A POTENT INHIBITOR OF KYNURENINE-3-HYDROXYLASE 37
Synthesis and Prelyminary Pharmacological Evaluation of the Four Stereoisomers of (2S)-2-(2’-Phosphono-3’-phenylcyclopropyl)glycine, the First Stereolibrary of trans 3’- Substituted -2-(2’-Phosphonocyclopropyl) glycine 36
Synthesis and biological evaluation of (2S)- and (2R)-2-(3'-phosphonobicyclo[1.1.1]pentyl)glycines as novel group III selective metabotropic glutamate receptor ligands. 36
New potent and selective mGluR1 competitive antagonists: pharmacological characterization and their exploitation in molecular modeling of receptor blocking 36
Synthesis, preliminary evaluation and molecular modeling studies of new, conformationally constrained analogues of the competitive NMDA receptor antagonist 4-(phosphonomethyl)-2-piperidinecarboxylic acid (CGS 19755) 36
HETEROCYCLIC MODULATORS OF THE NMDA RECEPTOR 35
Kynurenine-3-hydroxylase and its selective inhibitors. Molecular modeling studies. 34
PARP-1 and its inhibitors: molecular modeling studies 31
null 30
Farnesoid X receptor: from structure to potential clinical applications. 30
Modulation of glutamate receptor pathways in the search for new neuroprotective agents 29
Exploring the Molecular Dasis of the Selectivity in Metabotropic Glutamate Receptors (mGluRs) 29
Exploring Ligand Recognition in the Kynurenine Pathway to Advance the Medicinal Chemistry of Kynurenines 28
Synthesis and Preliminary Biological Evaluation of (2S,1’R,2’S)- and (2S,1’S,2’R)-2-(2Phosphonocyclopropyl)glycines, Two novel Conformationally Constrained L-AP4 Analogues 26
Novel Isoquinoline-Derived Inhibitors of Poly(ADP-Ribose) Polymerase-1: Pharmacological Characterization and Neuroprotective Effects in an in Vitro Model of Cerebral Ischemia 26
null 21
Identification of Human Alanine-Glyoxylate Aminotransferase Ligands as Pharmacological Chaperones for Variants Associated with Primary Hyperoxaluria Type 1 19
Synthesis and preliminary biological evaluation of (2S, 1'R, 2'S)- and (2S, 1'S,2' R)-2-(2-phosphonocyclopropyl)glycines, two novel conformationally constrained L-AP4 analogues 11
Totale 4.783
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Categoria #
all - tutte 18.245
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 18.245
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020355 0 0 0 0 85 6 87 5 77 30 14 51
2020/20211.090 6 91 42 79 243 60 85 3 122 38 94 227
2021/2022765 24 136 13 77 47 4 5 241 5 12 96 105
2022/20231.245 90 145 17 94 168 135 2 65 469 2 48 10
2023/2024464 36 65 29 6 10 8 72 6 68 27 53 84
2024/2025353 30 110 65 44 104 0 0 0 0 0 0 0
Totale 4.783