IRIS - Res&Arch Institutional Research Information System - Research & Archive

COSTANTINO, Gabriele
 Distribuzione geografica
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Continente #
NA - Nord America 2.142
EU - Europa 1.917
AS - Asia 786
SA - Sud America 33
AF - Africa 8
Continente sconosciuto - Info sul continente non disponibili 3
OC - Oceania 1
Totale 4.890
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Nazione #
US - Stati Uniti d'America 2.131
UA - Ucraina 533
SE - Svezia 367
IE - Irlanda 353
SG - Singapore 278
VN - Vietnam 212
DE - Germania 143
RU - Federazione Russa 143
HK - Hong Kong 127
IT - Italia 127
FI - Finlandia 95
CN - Cina 57
GB - Regno Unito 51
TR - Turchia 41
BE - Belgio 38
BR - Brasile 27
KR - Corea 20
FR - Francia 14
JP - Giappone 13
CA - Canada 10
CZ - Repubblica Ceca 10
UZ - Uzbekistan 10
LB - Libano 9
NL - Olanda 9
CH - Svizzera 8
IN - India 7
RO - Romania 6
PL - Polonia 5
AT - Austria 4
AE - Emirati Arabi Uniti 3
BD - Bangladesh 3
CI - Costa d'Avorio 3
EU - Europa 3
GR - Grecia 3
AR - Argentina 2
AZ - Azerbaigian 2
BG - Bulgaria 2
CO - Colombia 2
DK - Danimarca 2
EC - Ecuador 2
MA - Marocco 2
AU - Australia 1
EE - Estonia 1
EG - Egitto 1
HU - Ungheria 1
ID - Indonesia 1
JO - Giordania 1
MD - Moldavia 1
MX - Messico 1
NG - Nigeria 1
PK - Pakistan 1
PT - Portogallo 1
TW - Taiwan 1
ZA - Sudafrica 1
Totale 4.890
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Città #
Chandler 408
Dublin 352
Jacksonville 307
Dong Ket 211
San Mateo 200
Singapore 170
Boardman 129
Hong Kong 123
Santa Clara 98
Medford 85
Princeton 84
Ann Arbor 83
Wilmington 75
Andover 59
Altamura 43
Izmir 39
Brussels 37
Lawrence 35
Des Moines 33
Saint Petersburg 32
Moscow 28
Beijing 27
Perugia 24
Seoul 20
Ashburn 15
Los Angeles 15
Norwalk 15
Woodbridge 15
Auburn Hills 13
Helsinki 13
New York 11
San Paolo di Civitate 10
Shanghai 10
West Jordan 10
Brno 8
Philadelphia 7
Frankfurt Am Main 6
Tokyo 6
Den Haag 5
Ottawa 5
Mcallen 4
Redwood City 4
Timisoara 4
Toronto 4
Abidjan 3
Bhubaneswar 3
Chicago 3
Dearborn 3
Delhi 3
Falls Church 3
Fremont 3
Hanover 3
Kofu 3
Monopoli 3
Munich 3
Redmond 3
Roji 3
Rome 3
San Diego 3
Tashkent 3
Alameda 2
Baku 2
Bologna 2
Bordeaux 2
Bridgewater 2
Copenhagen 2
Dallas 2
Dhaka 2
Falkenstein 2
Fortaleza 2
Leawood 2
Milan 2
Parma 2
Rabat 2
Romola 2
San Jose 2
Sanayi 2
Simi Valley 2
Stockholm 2
São Paulo 2
Tappahannock 2
Verona 2
Vicenza 2
Abu Dhabi 1
Almirante Tamandaré 1
Amman 1
Amsterdam 1
Aracaju 1
Asyut 1
Baotou 1
Bauru 1
Beirã 1
Belo Horizonte 1
Berlin 1
Bogotá 1
Boydton 1
Budapest 1
Buffalo 1
Campinas 1
Campos dos Goytacazes 1
Totale 2.993
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Nome #
1,4 Benzothiazine and 1,4 benzoxazine imidazole derivatives with antifungal activity: a docking study 255
1-AMINOINDAN-1,5-DICARBOXYLIC ACID - A NOVEL ANTAGONIST AT PHOSPHOLIPASE C-LINKED METABOTROPIC GLUTAMATE RECEPTORS 180
Asymmetric synthesis of (2R, 1’S, 2’R, 3’S)-2-(2’- Carboxy-3’-phenylcyclopropyl)glicine (PCCG 13), the first selective antagonist of metabotropic glutamate receptors coupled phospholipase D 103
(2R,1’S,2’R,3’S)-2-(2’-Carboxy-3’-phenylcyclopropyl)glycine (PCCG-13), the First Potent and Selective Competitive Antagonist of Phospholipase D-Coupled Metabotropic Glutamate Receptors: Asymmetric Synthesis and Preliminary Biological Properties 87
Autocorrelation as a tool for a congruent description of molecu¬les in 3D-QSAR studies 85
Towards New Neuroprotective Agents: Design and Synthesis of Thieno[2,3-c]-isoquinolinon-5-one as a Potent PARP-1 Inhibitor. 84
Chromatographic separation and evaluation of the lipophilicity by reversed-phase high-performance liquid chromatography of fullerene-C60 derivatives 83
On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives. 81
Spiro[2.2]pentane as a Dissymmetric Scaffold for Conformationally Constrained Analogues of Glutamic Acid: Focus on Racemic 1-Aminospiro[2.2]pentyl-1,4-dicarboxylic Acids 80
Design, Synthesis and Preliminay Evaluation of Novel 3’-Substituted Carboxycyclopropylglycines as Antagonists at Group 2 Metabotropic Glutamate Receptors 79
Spiro[2.2]pentane as a dyssymetric scaffold for conformationally constrained analogues of glutamic acid: diastereodivergent synthesis of 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids 79
Novel PARP Inhibitors: Synthesis and Molecular Modeling Studies 78
The aryl hydrocarbon receptor (AhR) mediates the counter-regulatory effects of pelargonidins in models of inflammation and metabolic dysfunctions 78
Asymmetric Synthesis of Enantiomerically Pure (2S,1'S,2'S,3'R)-Phenylcarboxycyclopropylglycine (PCCG-4): a Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors 77
Metabotropic glutamate receptors: structure and new subtype-selective ligands 76
Design and synthesis of 4H-thieno[2,3-c]isoquinolin-5-one derivatives as potent PARP-1 inhibitors, on route of new antiischemic agents 75
Synthesis, Molecular Modeling and Preliminary Biological Evaluation of 1-Amino-3-Phospono-3-Cyclopentene-1-Carboxylic acid and 1-Amino-3-Phosphono-2-Cyclopentene-1-Carboxylic acid, Two Novel Agonists of Metabotropic Glutamate Receptors of Group III 74
Insights into Phenylalanine Derivatives Recognition of VLA-4 Integrin: from a Pharmacophoric Study to 3D-QSAR and Molecular Docking Analyses 74
Binding Mode of 6ECDCA, a Potent Bile Acid Agonist of the Farnesoid X Receptor (FXR) 70
Homology Modeling of AMPA Receptors: Route to the identification of noncompetitive antagonists binding site 69
Poly(ADP-ribose)-Polimerase-Catalyzed Hydrolysis of NAD+: QM/MM Simulation of the Enzyme Reaction 68
Design, Synthesis, and Microbiolgical Evaluation of New Candida albicans CYP51 Inhibitors 68
Bulky 1,4-benzoxazine derivatives with antifungal activity 67
Poly(ADP-ribose)-polymerase-catalyzed hydrolysis of NAD+: QM/MM simulation of the enzyme reaction. ChemMedChem. 2006 May;1(5):533-9. 66
Rat Brain Guanosine Binding Site:Biological Studies and Pseudo Receptor Construction 66
Metabotropic Glutamate Receptors: A Structural View Point 66
Modulators of the kynurenine pathway of triptophan metabolism. Synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylalanine, the first potent and selective kynurenine aminotransferse II (KAT II) inhibitor 66
S-(+)-2-(3'carboxy-bicyclo[1.1.1]pentyl)glycine, a structurally new group I metabotropic glutamate receptor antagonist 65
Binding modes of noncompetitive AMPA Antagonists: A computational approach 63
Prediction ability of regression models. Part 2. Selection of the best predictive PLS model 63
Generating Optimal Linear PLS Estimations (GOLPE): An Advanced Chemometric Tool for Handling 3D-QSAR Problems 62
Dirhodium(II)-tetraacetate-Mediated Decomposition of Ethyldiazo- acetate and Ethyldiazomalonate in the Presence of Fullerene. A New Procedure for the Selective Synthesis of [6-6]-Closed Methanofullerenes 61
"*-Diazocarbonyl Chemistry - Target Driven Applications" 60
Design, Molecular Modeling Studies, Synthesis and Preliminary Evaluation of Novel PARP-1 Inhibitors on the Road of Antiischemic Agents 60
GOLPE: An Advanced Chemometric Tool for 3D-QSAR Problems 58
Molecular dynamics simulation of the ligand binding domain of mGluR1 in response to agonist and antagonist binding. 57
Disjoint Principal Properties of Organic Substituents 57
Definition of a pharmacophore for the metabotropic glutamate receptors negatively linked to adenylyl cyclase 56
Conformational requirements for interaction of L-glutamate with the metabotropic EAA receptor 54
Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist 53
Pharmacophore Models of Group I and Group II Metabotropic Glutamate Receptors Agonists. Analysis of Conformational, Steric and Topological Parameters Affecting Potency and Selectivity 52
Evaluation of Hydrophobic/Hydrophilic Balance of Bile Acids by Comparative Molecular Field Analysis (CoMFA) 52
Rat brain guanosine binding site. Biological studies and pseudo-Receptor construction 51
Metabotropic glutamate receptors: new ligands and molecular modelling studies 51
Discovery of a AHR pelargonidin agonist that counter-regulates Ace2 expression and attenuates ACE2-SARS-CoV-2 interaction 51
Pharmacophore model for bile acids recognition by the FPR receptor. 50
Synthesis and Biological Evaluation of 2-(3’-(1H-tetrazol-5-yl)bicyclo[1.1.1]pent-1-yl)glycine (S-TBPG), a novel mGlu1 Receptor 50
Tu1738 - The Aryl Hydrocarbon Receptor Mediates Anti-Inflammatory Activities of Natural and Synthetic Pelargonidines in Mouse Models of Colitis 50
Potential Therapeutic Applications of Farnesoid X Receptor (FXR) Modulators 49
Molecular Dynamics Simulation of the Ligand Binding Domain of Farnesoid X Receptor (FXR). Insights into Helix-12 Stability and Coactivator Peptide Stabilization in Response to Agonist Binding 48
SYNTHESIS AND BIOLOGICAL EVALUATION OF 6-CARBOXY-3,4-METHANOPROLINES, NEW RIGID GLUTAMATE ANALOGS 48
Molecular determinats for metabotropic glutamate receptor activation and blockade. Molecular dynamics and electrostatic potential analysis studies 48
Series design 48
Studies guanosine binding sites in rat brain: S.A.R. analysis and pharmacophore design 47
Stereoselective Synthesis and Preliminary Evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): Identification of (+)-3-MATIDA as a Novel mGluR1 Competitive Antagonist 47
Studies on the interaction between PARP’s catalytic site and inhibitors. Design and synthesis of new class of inhibitor derivatives 47
Bile Acid Derivatives as Ligands of the Farnesoid X Receptor. Synthesis, Evaluation, and Structure Activity Relationship of a Series of Body and Side Chain Modified Analogs of Chenodeoxycholic Acid 47
Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study. 46
Docking studies on PARP-1 inhibitors: insights into the role of a binding pocket water molecole. 46
On the Way to Selective PARP-2 Inhibitors: Design, Synthesis and Preliminary Evaluation of a Series of Isoquinolinone Derivatives 46
Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase. 46
HETEROCYCLIC MODULATORS OF THE NMDA RECEPTOR 44
The Pseudoactive Site as a Tool for Indirect Drug Design. Application to Inhibitors of Kynurenine-3-hydroxylase 43
Prediction ability of regression models. Part 1. Standard deviation of prediction errors (SDEP) 42
Synthesis and Preliminary Biological Evaluation of glycineb site (+)- and (-)-3-Oxetanylglycine, Novel non-Proteinogenic Amino Acids 41
Metabotropic Glutamate Receptors: Targets for Therapy of Cerebral Ischemia 40
Homology Model of the Multidrag transporter LmrA from Lactococcus Lactis 40
Synthesis of 6,6-dicarboxy-3,4-methano-L-proline, a new constrained glutamate analog endowed with neuroprotective properties 40
Synthesis and Prelyminary Pharmacological Evaluation of the Four Stereoisomers of (2S)-2-(2’-Phosphono-3’-phenylcyclopropyl)glycine, the First Stereolibrary of trans 3’- Substituted -2-(2’-Phosphonocyclopropyl) glycine 39
Homology Model of the Closed, Functionally Active, Form of the Amino Terminal Domain of mGluR1 39
MODULATION OF THE KYNURENINE PATHWAY IN SEARCH FOR NEW NEUROPROTECTIVE AGENTS - SYNTHESIS AND PRELIMINARY EVALUATION OF (M-NITROBENZOYL)ALANINE, A POTENT INHIBITOR OF KYNURENINE-3-HYDROXYLASE 39
Farnesoid X receptor: from structure to potential clinical applications. 39
Synthesis and biological evaluation of (2S)- and (2R)-2-(3'-phosphonobicyclo[1.1.1]pentyl)glycines as novel group III selective metabotropic glutamate receptor ligands. 38
Towards Selective PARP-2 Inhibitors: Design, Synthesis and Preliminary Evaluation of a Series of Isoquinolinone Derivatives 38
Synthesis, preliminary evaluation and molecular modeling studies of new, conformationally constrained analogues of the competitive NMDA receptor antagonist 4-(phosphonomethyl)-2-piperidinecarboxylic acid (CGS 19755) 38
New potent and selective mGluR1 competitive antagonists: pharmacological characterization and their exploitation in molecular modeling of receptor blocking 37
Kynurenine-3-hydroxylase and its selective inhibitors. Molecular modeling studies. 37
Identification of Human Alanine-Glyoxylate Aminotransferase Ligands as Pharmacological Chaperones for Variants Associated with Primary Hyperoxaluria Type 1 34
PARP-1 and its inhibitors: molecular modeling studies 32
Exploring the Molecular Dasis of the Selectivity in Metabotropic Glutamate Receptors (mGluRs) 32
Modulation of glutamate receptor pathways in the search for new neuroprotective agents 31
Exploring Ligand Recognition in the Kynurenine Pathway to Advance the Medicinal Chemistry of Kynurenines 31
null 30
Novel Isoquinoline-Derived Inhibitors of Poly(ADP-Ribose) Polymerase-1: Pharmacological Characterization and Neuroprotective Effects in an in Vitro Model of Cerebral Ischemia 30
Synthesis and Preliminary Biological Evaluation of (2S,1’R,2’S)- and (2S,1’S,2’R)-2-(2Phosphonocyclopropyl)glycines, Two novel Conformationally Constrained L-AP4 Analogues 27
null 21
Synthesis and preliminary biological evaluation of (2S, 1'R, 2'S)- and (2S, 1'S,2' R)-2-(2-phosphonocyclopropyl)glycines, two novel conformationally constrained L-AP4 analogues 13
Totale 5.038
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Categoria #
all - tutte 20.695
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 20.695
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020172 0 0 0 0 0 0 0 0 77 30 14 51
2020/20211.090 6 91 42 79 243 60 85 3 122 38 94 227
2021/2022765 24 136 13 77 47 4 5 241 5 12 96 105
2022/20231.245 90 145 17 94 168 135 2 65 469 2 48 10
2023/2024464 36 65 29 6 10 8 72 6 68 27 53 84
2024/2025608 30 110 65 44 114 17 23 77 128 0 0 0
Totale 5.038