IRIS - Res&Arch Institutional Research Information System - Research & Archive

COSTANTINO, Gabriele
 Distribuzione geografica
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Continente #
NA - Nord America 3.088
EU - Europa 2.344
AS - Asia 2.012
SA - Sud America 297
Continente sconosciuto - Info sul continente non disponibili 151
AF - Africa 45
OC - Oceania 3
Totale 7.940
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Nazione #
US - Stati Uniti d'America 3.021
SG - Singapore 861
UA - Ucraina 538
SE - Svezia 377
IE - Irlanda 355
RU - Federazione Russa 304
VN - Vietnam 289
HK - Hong Kong 248
CN - Cina 244
BR - Brasile 222
DE - Germania 179
IT - Italia 157
FI - Finlandia 109
KR - Corea 106
FR - Francia 100
GB - Regno Unito 81
TR - Turchia 57
IN - India 41
BE - Belgio 39
CA - Canada 32
JP - Giappone 30
BD - Bangladesh 23
PL - Polonia 22
AR - Argentina 19
CO - Colombia 19
IQ - Iraq 18
MX - Messico 18
UZ - Uzbekistan 17
NL - Olanda 16
ZA - Sudafrica 16
CZ - Repubblica Ceca 13
LB - Libano 11
VE - Venezuela 11
EC - Ecuador 10
CH - Svizzera 9
PK - Pakistan 8
AT - Austria 7
ID - Indonesia 7
KE - Kenya 7
PH - Filippine 7
PY - Paraguay 7
RO - Romania 6
SA - Arabia Saudita 6
ES - Italia 5
LT - Lituania 5
DZ - Algeria 4
GR - Grecia 4
JO - Giordania 4
MA - Marocco 4
MY - Malesia 4
PE - Perù 4
TH - Thailandia 4
AE - Emirati Arabi Uniti 3
AU - Australia 3
CI - Costa d'Avorio 3
EU - Europa 3
HN - Honduras 3
IL - Israele 3
KW - Kuwait 3
NP - Nepal 3
OM - Oman 3
PA - Panama 3
TN - Tunisia 3
AZ - Azerbaigian 2
BG - Bulgaria 2
BH - Bahrain 2
BO - Bolivia 2
CL - Cile 2
DK - Danimarca 2
DO - Repubblica Dominicana 2
EE - Estonia 2
ET - Etiopia 2
HR - Croazia 2
JM - Giamaica 2
NG - Nigeria 2
PT - Portogallo 2
TW - Taiwan 2
AL - Albania 1
BB - Barbados 1
BJ - Benin 1
BN - Brunei Darussalam 1
BW - Botswana 1
BY - Bielorussia 1
CR - Costa Rica 1
CY - Cipro 1
EG - Egitto 1
GD - Grenada 1
GE - Georgia 1
GT - Guatemala 1
HU - Ungheria 1
IR - Iran 1
IS - Islanda 1
KH - Cambogia 1
MD - Moldavia 1
ME - Montenegro 1
MK - Macedonia 1
MN - Mongolia 1
PR - Porto Rico 1
SI - Slovenia 1
SN - Senegal 1
Totale 7.789
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Città #
Singapore 553
Chandler 408
Dublin 354
Jacksonville 308
Hong Kong 244
San Jose 214
Dong Ket 211
San Mateo 200
Ashburn 162
Boardman 129
Santa Clara 126
Seoul 106
Moscow 101
Medford 85
Princeton 84
Ann Arbor 83
Lauterbourg 77
Wilmington 75
Beijing 61
Andover 59
Los Angeles 59
Altamura 43
New York 43
Izmir 39
Piscataway 39
Brussels 38
Lawrence 35
Des Moines 33
Saint Petersburg 32
Munich 30
The Dalles 30
São Paulo 28
Perugia 25
Hanoi 24
Tokyo 23
Orem 21
Ho Chi Minh City 20
Helsinki 16
Phoenix 16
Warsaw 16
Norwalk 15
Woodbridge 15
Auburn Hills 13
Boston 13
Denver 13
Chennai 12
Houston 12
Shanghai 12
Stockholm 12
Johannesburg 11
Turku 11
Baghdad 10
Dallas 10
San Paolo di Civitate 10
West Jordan 10
Brooklyn 9
Milan 9
Montreal 9
Tashkent 9
Toronto 9
Brno 8
Chicago 8
Philadelphia 8
Poplar 8
San Francisco 8
Amsterdam 7
Ankara 7
Manchester 7
Rio de Janeiro 7
Bogotá 6
Council Bluffs 6
Delhi 6
Frankfurt Am Main 6
London 6
Mexico City 6
Nairobi 6
Nuremberg 6
Quito 6
Rome 6
Atlanta 5
Buffalo 5
Cleveland 5
Columbus 5
Den Haag 5
Hefei 5
Ottawa 5
Amman 4
Asunción 4
Bhubaneswar 4
Bologna 4
Brasília 4
Charlotte 4
Da Nang 4
Dhaka 4
Haiphong 4
Lagoa da Prata 4
Manaus 4
Mcallen 4
Mumbai 4
Olomouc 4
Totale 4.693
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Nome #
1,4 Benzothiazine and 1,4 benzoxazine imidazole derivatives with antifungal activity: a docking study 328
1-AMINOINDAN-1,5-DICARBOXYLIC ACID - A NOVEL ANTAGONIST AT PHOSPHOLIPASE C-LINKED METABOTROPIC GLUTAMATE RECEPTORS 226
Asymmetric synthesis of (2R, 1’S, 2’R, 3’S)-2-(2’- Carboxy-3’-phenylcyclopropyl)glicine (PCCG 13), the first selective antagonist of metabotropic glutamate receptors coupled phospholipase D 180
Autocorrelation as a tool for a congruent description of molecu¬les in 3D-QSAR studies 132
Asymmetric Synthesis of Enantiomerically Pure (2S,1'S,2'S,3'R)-Phenylcarboxycyclopropylglycine (PCCG-4): a Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors 127
Binding Mode of 6ECDCA, a Potent Bile Acid Agonist of the Farnesoid X Receptor (FXR) 123
(2R,1’S,2’R,3’S)-2-(2’-Carboxy-3’-phenylcyclopropyl)glycine (PCCG-13), the First Potent and Selective Competitive Antagonist of Phospholipase D-Coupled Metabotropic Glutamate Receptors: Asymmetric Synthesis and Preliminary Biological Properties 123
Spiro[2.2]pentane as a Dissymmetric Scaffold for Conformationally Constrained Analogues of Glutamic Acid: Focus on Racemic 1-Aminospiro[2.2]pentyl-1,4-dicarboxylic Acids 120
Bulky 1,4-benzoxazine derivatives with antifungal activity 119
The aryl hydrocarbon receptor (AhR) mediates the counter-regulatory effects of pelargonidins in models of inflammation and metabolic dysfunctions 119
Towards New Neuroprotective Agents: Design and Synthesis of Thieno[2,3-c]-isoquinolinon-5-one as a Potent PARP-1 Inhibitor. 118
Insights into Phenylalanine Derivatives Recognition of VLA-4 Integrin: from a Pharmacophoric Study to 3D-QSAR and Molecular Docking Analyses 117
"*-Diazocarbonyl Chemistry - Target Driven Applications" 116
Spiro[2.2]pentane as a dyssymetric scaffold for conformationally constrained analogues of glutamic acid: diastereodivergent synthesis of 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids 116
Chromatographic separation and evaluation of the lipophilicity by reversed-phase high-performance liquid chromatography of fullerene-C60 derivatives 114
Design, Synthesis and Preliminay Evaluation of Novel 3’-Substituted Carboxycyclopropylglycines as Antagonists at Group 2 Metabotropic Glutamate Receptors 113
GOLPE: An Advanced Chemometric Tool for 3D-QSAR Problems 113
Design, Synthesis, and Microbiolgical Evaluation of New Candida albicans CYP51 Inhibitors 112
Discovery of a AHR pelargonidin agonist that counter-regulates Ace2 expression and attenuates ACE2-SARS-CoV-2 interaction 112
Metabotropic glutamate receptors: structure and new subtype-selective ligands 111
On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives. 110
Modulators of the kynurenine pathway of triptophan metabolism. Synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylalanine, the first potent and selective kynurenine aminotransferse II (KAT II) inhibitor 109
Design and synthesis of 4H-thieno[2,3-c]isoquinolin-5-one derivatives as potent PARP-1 inhibitors, on route of new antiischemic agents 107
Dirhodium(II)-tetraacetate-Mediated Decomposition of Ethyldiazo- acetate and Ethyldiazomalonate in the Presence of Fullerene. A New Procedure for the Selective Synthesis of [6-6]-Closed Methanofullerenes 105
Homology Modeling of AMPA Receptors: Route to the identification of noncompetitive antagonists binding site 105
Design, Molecular Modeling Studies, Synthesis and Preliminary Evaluation of Novel PARP-1 Inhibitors on the Road of Antiischemic Agents 105
S-(+)-2-(3'carboxy-bicyclo[1.1.1]pentyl)glycine, a structurally new group I metabotropic glutamate receptor antagonist 102
Novel PARP Inhibitors: Synthesis and Molecular Modeling Studies 100
Binding modes of noncompetitive AMPA Antagonists: A computational approach 100
Definition of a pharmacophore for the metabotropic glutamate receptors negatively linked to adenylyl cyclase 100
Synthesis, Molecular Modeling and Preliminary Biological Evaluation of 1-Amino-3-Phospono-3-Cyclopentene-1-Carboxylic acid and 1-Amino-3-Phosphono-2-Cyclopentene-1-Carboxylic acid, Two Novel Agonists of Metabotropic Glutamate Receptors of Group III 97
Poly(ADP-ribose)-Polimerase-Catalyzed Hydrolysis of NAD+: QM/MM Simulation of the Enzyme Reaction 96
Rat Brain Guanosine Binding Site:Biological Studies and Pseudo Receptor Construction 96
Rat brain guanosine binding site. Biological studies and pseudo-Receptor construction 93
Molecular Dynamics Simulation of the Ligand Binding Domain of Farnesoid X Receptor (FXR). Insights into Helix-12 Stability and Coactivator Peptide Stabilization in Response to Agonist Binding 92
Metabotropic Glutamate Receptors: A Structural View Point 91
Generating Optimal Linear PLS Estimations (GOLPE): An Advanced Chemometric Tool for Handling 3D-QSAR Problems 91
Poly(ADP-ribose)-polymerase-catalyzed hydrolysis of NAD+: QM/MM simulation of the enzyme reaction. ChemMedChem. 2006 May;1(5):533-9. 90
Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist 90
Evaluation of Hydrophobic/Hydrophilic Balance of Bile Acids by Comparative Molecular Field Analysis (CoMFA) 89
Molecular determinats for metabotropic glutamate receptor activation and blockade. Molecular dynamics and electrostatic potential analysis studies 89
Disjoint Principal Properties of Organic Substituents 88
Molecular dynamics simulation of the ligand binding domain of mGluR1 in response to agonist and antagonist binding. 87
Prediction ability of regression models. Part 2. Selection of the best predictive PLS model 87
Bile Acid Derivatives as Ligands of the Farnesoid X Receptor. Synthesis, Evaluation, and Structure Activity Relationship of a Series of Body and Side Chain Modified Analogs of Chenodeoxycholic Acid 86
Metabotropic glutamate receptors: new ligands and molecular modelling studies 85
Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase. 85
Potential Therapeutic Applications of Farnesoid X Receptor (FXR) Modulators 84
Pharmacophore model for bile acids recognition by the FPR receptor. 82
Conformational requirements for interaction of L-glutamate with the metabotropic EAA receptor 82
Tu1738 - The Aryl Hydrocarbon Receptor Mediates Anti-Inflammatory Activities of Natural and Synthetic Pelargonidines in Mouse Models of Colitis 80
The Pseudoactive Site as a Tool for Indirect Drug Design. Application to Inhibitors of Kynurenine-3-hydroxylase 78
Identification of Human Alanine-Glyoxylate Aminotransferase Ligands as Pharmacological Chaperones for Variants Associated with Primary Hyperoxaluria Type 1 77
Pharmacophore Models of Group I and Group II Metabotropic Glutamate Receptors Agonists. Analysis of Conformational, Steric and Topological Parameters Affecting Potency and Selectivity 77
Synthesis and Biological Evaluation of 2-(3’-(1H-tetrazol-5-yl)bicyclo[1.1.1]pent-1-yl)glycine (S-TBPG), a novel mGlu1 Receptor 76
On the Way to Selective PARP-2 Inhibitors: Design, Synthesis and Preliminary Evaluation of a Series of Isoquinolinone Derivatives 75
MODULATION OF THE KYNURENINE PATHWAY IN SEARCH FOR NEW NEUROPROTECTIVE AGENTS - SYNTHESIS AND PRELIMINARY EVALUATION OF (M-NITROBENZOYL)ALANINE, A POTENT INHIBITOR OF KYNURENINE-3-HYDROXYLASE 74
Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study. 73
Studies on the interaction between PARP’s catalytic site and inhibitors. Design and synthesis of new class of inhibitor derivatives 73
Novel Isoquinoline-Derived Inhibitors of Poly(ADP-Ribose) Polymerase-1: Pharmacological Characterization and Neuroprotective Effects in an in Vitro Model of Cerebral Ischemia 73
Stereoselective Synthesis and Preliminary Evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): Identification of (+)-3-MATIDA as a Novel mGluR1 Competitive Antagonist 72
Towards Selective PARP-2 Inhibitors: Design, Synthesis and Preliminary Evaluation of a Series of Isoquinolinone Derivatives 72
HETEROCYCLIC MODULATORS OF THE NMDA RECEPTOR 72
Docking studies on PARP-1 inhibitors: insights into the role of a binding pocket water molecole. 70
SYNTHESIS AND BIOLOGICAL EVALUATION OF 6-CARBOXY-3,4-METHANOPROLINES, NEW RIGID GLUTAMATE ANALOGS 70
Series design 69
Synthesis and Prelyminary Pharmacological Evaluation of the Four Stereoisomers of (2S)-2-(2’-Phosphono-3’-phenylcyclopropyl)glycine, the First Stereolibrary of trans 3’- Substituted -2-(2’-Phosphonocyclopropyl) glycine 68
Kynurenine-3-hydroxylase and its selective inhibitors. Molecular modeling studies. 68
Exploring Ligand Recognition in the Kynurenine Pathway to Advance the Medicinal Chemistry of Kynurenines 68
Synthesis, preliminary evaluation and molecular modeling studies of new, conformationally constrained analogues of the competitive NMDA receptor antagonist 4-(phosphonomethyl)-2-piperidinecarboxylic acid (CGS 19755) 67
Prediction ability of regression models. Part 1. Standard deviation of prediction errors (SDEP) 67
Farnesoid X receptor: from structure to potential clinical applications. 66
Exploring the Molecular Dasis of the Selectivity in Metabotropic Glutamate Receptors (mGluRs) 65
Studies guanosine binding sites in rat brain: S.A.R. analysis and pharmacophore design 64
Synthesis of 6,6-dicarboxy-3,4-methano-L-proline, a new constrained glutamate analog endowed with neuroprotective properties 63
Metabotropic Glutamate Receptors: Targets for Therapy of Cerebral Ischemia 61
Homology Model of the Closed, Functionally Active, Form of the Amino Terminal Domain of mGluR1 61
Synthesis and biological evaluation of (2S)- and (2R)-2-(3'-phosphonobicyclo[1.1.1]pentyl)glycines as novel group III selective metabotropic glutamate receptor ligands. 61
Synthesis and Preliminary Biological Evaluation of glycineb site (+)- and (-)-3-Oxetanylglycine, Novel non-Proteinogenic Amino Acids 59
Homology Model of the Multidrag transporter LmrA from Lactococcus Lactis 57
New potent and selective mGluR1 competitive antagonists: pharmacological characterization and their exploitation in molecular modeling of receptor blocking 57
Synthesis and Preliminary Biological Evaluation of (2S,1’R,2’S)- and (2S,1’S,2’R)-2-(2Phosphonocyclopropyl)glycines, Two novel Conformationally Constrained L-AP4 Analogues 55
PARP-1 and its inhibitors: molecular modeling studies 53
Modulation of glutamate receptor pathways in the search for new neuroprotective agents 53
Synthesis and preliminary biological evaluation of (2S, 1'R, 2'S)- and (2S, 1'S,2' R)-2-(2-phosphonocyclopropyl)glycines, two novel conformationally constrained L-AP4 analogues 33
null 30
null 21
Totale 7.940
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Categoria #
all - tutte 34.149
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 34.149
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022605 0 0 13 77 47 4 5 241 5 12 96 105
2022/20231.245 90 145 17 94 168 135 2 65 469 2 48 10
2023/2024464 36 65 29 6 10 8 72 6 68 27 53 84
2024/20251.065 30 110 65 44 114 17 23 77 226 66 161 132
2025/20262.261 199 220 116 270 252 263 359 88 256 186 34 18
2026/2027184 50 86 48 0 0 0 0 0 0 0 0 0
Totale 7.940