The nucleocapsid p7 (NCp7) protein is an enzyme-like, zinc-finger protein that plays a pivotal role within the HIV replicative cycle . The inhibition of its activity results in the interruption of viral replication without selecting resistant strains. Taking advantage of the SAR collected with the known zinc ejector, disulfide-based NCp7 inhibitors, a number of diselenides containing the structural core of benzoic and nicotinic acid were synthesized to test their anti-HIV activity. The synthesis and the structural elucidation are here reported.
Design and synthesis of new biologically active diselenides
SANCINETO, LUCA;TIDEI, CATERINA;BAGNOLI, Luana;MARINI, Francesca;TABARRINI, Oriana;SANTI, Claudio
2013
Abstract
The nucleocapsid p7 (NCp7) protein is an enzyme-like, zinc-finger protein that plays a pivotal role within the HIV replicative cycle . The inhibition of its activity results in the interruption of viral replication without selecting resistant strains. Taking advantage of the SAR collected with the known zinc ejector, disulfide-based NCp7 inhibitors, a number of diselenides containing the structural core of benzoic and nicotinic acid were synthesized to test their anti-HIV activity. The synthesis and the structural elucidation are here reported.File in questo prodotto:
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