GISTs arise from mesenchymal precursor cells of the gastrointestinal tract that may differentiate towards the interstitial cells of Cajal, pacemaker cells regulating autonomous motility of G.I. tract. About 60% of GISTs are found in the stomach, 20–50% in the small bowel (one third in the duodenum), and 5–15% in colon and rectum; GISTs, however, may rarely be found also in the oesophagus, omentum, mesentery or the retroperitoneum. The distribution of these tumors in the stomach is: pars media, 40%; antrum, 25%; pylorus, 20%. In less than 15%, GISTs location is next to the EGJ, in the cardia and in the fundus.1 , 2 Gastric GISTs may also present as pedunculated, exophytic masses. This pattern of growth is rare, and diagnosis is often made after surgery, since the lack of specific symptoms.3 , 4 , 5 , 6 , 7 The Authors report two cases of pedunculated gastric GIST with totally extraluminal growth.
Pedunculated giant GISTs of the stomach with exophytic growth: Report of two cases
Polistena, Andrea;
2008
Abstract
GISTs arise from mesenchymal precursor cells of the gastrointestinal tract that may differentiate towards the interstitial cells of Cajal, pacemaker cells regulating autonomous motility of G.I. tract. About 60% of GISTs are found in the stomach, 20–50% in the small bowel (one third in the duodenum), and 5–15% in colon and rectum; GISTs, however, may rarely be found also in the oesophagus, omentum, mesentery or the retroperitoneum. The distribution of these tumors in the stomach is: pars media, 40%; antrum, 25%; pylorus, 20%. In less than 15%, GISTs location is next to the EGJ, in the cardia and in the fundus.1 , 2 Gastric GISTs may also present as pedunculated, exophytic masses. This pattern of growth is rare, and diagnosis is often made after surgery, since the lack of specific symptoms.3 , 4 , 5 , 6 , 7 The Authors report two cases of pedunculated gastric GIST with totally extraluminal growth.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
