Introduction: Anaplastic thyroid carcinoma (ATC) is characterized by local invasiveness, risk of recur- rence and very poor prognosis. Methods: We retrospectively analysed the multimodality treatment of ATC in 79 patients considering the impact of surgery on survival. Results: Patients were divided in two age groups A and B (cut-off 75 years) and in two size subgroups (cut-off 5 cm). Surgery was performed in 78.5% patients of group A and 32.4% of B (p < 0.05). Radiation respectively in 73.8% and 43.2% (p < 0.05). Tracheostomy and endoprosthesis were used in 45.2% and 16.6% in group A and in 43.2% and 35.1% in group B. The use of tracheostomy was significantly higher (p < 0.05) in larger tumours. In group B comparing operated and not operated patients significant difference in survival was observed for larger tumours (p 1⁄4 0.043). In Kaplan Meir analysis significant difference in survival was observed comparing surgical and no surgical patients of all four subgroups. Surgery plus radiotherapy offered a significant better outcome in smaller tumours (p 1⁄4 0.017). Considering the effect of the single treatment, compared to no treatment at all, survival is significantly improved by surgery for smaller and larger tumours respectively with 4.42 (p 1⁄4 0.001) and with 3.5 months (p 1⁄4 0.0001) and by radiotherapy respectively with 3.44 and with 3.28 months (p 1⁄4 0.047 and p 1⁄4 0.0001). Conclusion: In elderly patients with ATC, although poor prognosis, surgery is still fundamental in the multimodality treatment with significant advantage in selected patients. Nevertheless most of elderly patients with large tumours are suitable only for palliative management.
The role of surgery in the treatment of thyroid anaplastic carcinoma in the elderly
Polistena, Andrea;MONACELLI, Massimo;RONDELLI, Fabio;BUGIANTELLA, WALTER;BARILLARO, IVAN;AVENIA, Nicola
2014
Abstract
Introduction: Anaplastic thyroid carcinoma (ATC) is characterized by local invasiveness, risk of recur- rence and very poor prognosis. Methods: We retrospectively analysed the multimodality treatment of ATC in 79 patients considering the impact of surgery on survival. Results: Patients were divided in two age groups A and B (cut-off 75 years) and in two size subgroups (cut-off 5 cm). Surgery was performed in 78.5% patients of group A and 32.4% of B (p < 0.05). Radiation respectively in 73.8% and 43.2% (p < 0.05). Tracheostomy and endoprosthesis were used in 45.2% and 16.6% in group A and in 43.2% and 35.1% in group B. The use of tracheostomy was significantly higher (p < 0.05) in larger tumours. In group B comparing operated and not operated patients significant difference in survival was observed for larger tumours (p 1⁄4 0.043). In Kaplan Meir analysis significant difference in survival was observed comparing surgical and no surgical patients of all four subgroups. Surgery plus radiotherapy offered a significant better outcome in smaller tumours (p 1⁄4 0.017). Considering the effect of the single treatment, compared to no treatment at all, survival is significantly improved by surgery for smaller and larger tumours respectively with 4.42 (p 1⁄4 0.001) and with 3.5 months (p 1⁄4 0.0001) and by radiotherapy respectively with 3.44 and with 3.28 months (p 1⁄4 0.047 and p 1⁄4 0.0001). Conclusion: In elderly patients with ATC, although poor prognosis, surgery is still fundamental in the multimodality treatment with significant advantage in selected patients. Nevertheless most of elderly patients with large tumours are suitable only for palliative management.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
