The large variety of microbial species in the human microbiome plays an important role in humanhealth by affecting tissue differentiation,modulation of the immune system, as well as the general response against infectious pathogens. The aryl hydrocarbon receptor (AhR) contributes to immune homeostasis as having an antimicrobial role on the one hand – owing to AhR-dependent IL-22 transcription – and, on the other, an anti-inflammatory role in that it mediates the differentiation of regulatory T cells (Tregs). Here, we have examined the multifaceted physiological role of AhR as resulting fromthe vast array of recently described AhR ligands and of the multiplicity of AhR-expressing cells in host-microbial symbiosis in mammals.
Tryptophan Feeding of the IDO1-AhR Axis in Host-Microbial Symbiosis
ZELANTE, TERESA;IANNITTI, ROSSANA GIULIETTA;FALLARINO, Francesca;GARGARO, MARCO;DE LUCA, ANTONELLA;MORETTI, SILVIA;BARTOLI, Andrea;ROMANI, Luigina
2014
Abstract
The large variety of microbial species in the human microbiome plays an important role in humanhealth by affecting tissue differentiation,modulation of the immune system, as well as the general response against infectious pathogens. The aryl hydrocarbon receptor (AhR) contributes to immune homeostasis as having an antimicrobial role on the one hand – owing to AhR-dependent IL-22 transcription – and, on the other, an anti-inflammatory role in that it mediates the differentiation of regulatory T cells (Tregs). Here, we have examined the multifaceted physiological role of AhR as resulting fromthe vast array of recently described AhR ligands and of the multiplicity of AhR-expressing cells in host-microbial symbiosis in mammals.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
