A new protocol for the diasteroselective synthesis of pyrrolidin-2-ones 4−14 is presented. Aquivion PFSA effectively catalyzed the diasteroselective nitro-mannich/lactamization cascade reaction between the imine formed from aldehydes 1a−g and amines 2a−b with methyl 3-nitropropanoate 3. The use of flow conditions allow a very efficient waste minimization confirmed by representative green metrics calculations.
Aquivion® PFSA as a novel solid and reusable acid catalyst in the synthesis of 2-pyrrolidin-2-ones in flow
BIANCHI, LUCA;CURINI, Massimo;LANARI, DANIELA;MARROCCHI, Assunta;VACCARO, Luigi
2015
Abstract
A new protocol for the diasteroselective synthesis of pyrrolidin-2-ones 4−14 is presented. Aquivion PFSA effectively catalyzed the diasteroselective nitro-mannich/lactamization cascade reaction between the imine formed from aldehydes 1a−g and amines 2a−b with methyl 3-nitropropanoate 3. The use of flow conditions allow a very efficient waste minimization confirmed by representative green metrics calculations.File in questo prodotto:
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