A new protocol for the diasteroselective synthesis of pyrrolidin-2-ones 4−14 is presented. Aquivion PFSA effectively catalyzed the diasteroselective nitro-mannich/lactamization cascade reaction between the imine formed from aldehydes 1a−g and amines 2a−b with methyl 3-nitropropanoate 3. The use of flow conditions allow a very efficient waste minimization confirmed by representative green metrics calculations.

Aquivion® PFSA as a novel solid and reusable acid catalyst in the synthesis of 2-pyrrolidin-2-ones in flow

BIANCHI, LUCA;CURINI, Massimo;LANARI, DANIELA;MARROCCHI, Assunta;VACCARO, Luigi
2015

Abstract

A new protocol for the diasteroselective synthesis of pyrrolidin-2-ones 4−14 is presented. Aquivion PFSA effectively catalyzed the diasteroselective nitro-mannich/lactamization cascade reaction between the imine formed from aldehydes 1a−g and amines 2a−b with methyl 3-nitropropanoate 3. The use of flow conditions allow a very efficient waste minimization confirmed by representative green metrics calculations.
2015
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1361751
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 34
  • ???jsp.display-item.citation.isi??? 31
social impact