Herein, we disclose a general and flexible access to spirocyclopropyl oxindoles by a domino Michael/ intramolecular nucleophilic substitution pathway with variously substituted vinyl selenones and enolizable oxindoles in aqueous sodium hydroxide solution. The spirocyclopropyl oxindole being a privileged scaffold, some of the synthesized compounds were selected for biological evaluation. Compound 3m showed selective anti-HIV-1 activity thanks to its ability to inhibit the reverse transcriptase.

A new vinyl selenone-based domino approach to spirocyclopropyl oxindoles endowed with anti-HIV RT activity

PALOMBA, MARTINA;SANCINETO, LUCA;BAGNOLI, Luana;SANTI, Claudio;TABARRINI, Oriana;MARINI, Francesca
2016

Abstract

Herein, we disclose a general and flexible access to spirocyclopropyl oxindoles by a domino Michael/ intramolecular nucleophilic substitution pathway with variously substituted vinyl selenones and enolizable oxindoles in aqueous sodium hydroxide solution. The spirocyclopropyl oxindole being a privileged scaffold, some of the synthesized compounds were selected for biological evaluation. Compound 3m showed selective anti-HIV-1 activity thanks to its ability to inhibit the reverse transcriptase.
2016
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1374737
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