Two new lignans, namely 7-O-podophyllotoxinyl butyrate (1) and dihydroclusin 9-acetate (2), were isolated from the dichloromethane fraction of a methanol extract of Bursera microphylla (Burseraceae), along with eight known lignans (3–10). Their structures were determined by means of comprehensive spectroscopic analysis. Lignans 2–6 were tested for their anti-proliferative activity on the cancer cell lines LS180, A549 and HeLa, and on a non-cancer cell line, ARPE-19. Only compounds 4 and 5 showed an interesting activity on HeLa cells.

Two new lignans from the resin of Bursera microphylla A. Gray and their cytotoxic activity

GIGLIARELLI, GIULIA
Investigation
;
ZADRA, Claudia
Investigation
;
COSSIGNANI, Lina
Data Curation
;
MARCOTULLIO, Maria Carla
Supervision
2018

Abstract

Two new lignans, namely 7-O-podophyllotoxinyl butyrate (1) and dihydroclusin 9-acetate (2), were isolated from the dichloromethane fraction of a methanol extract of Bursera microphylla (Burseraceae), along with eight known lignans (3–10). Their structures were determined by means of comprehensive spectroscopic analysis. Lignans 2–6 were tested for their anti-proliferative activity on the cancer cell lines LS180, A549 and HeLa, and on a non-cancer cell line, ARPE-19. Only compounds 4 and 5 showed an interesting activity on HeLa cells.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1417130
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