Loss-of-function mutations of CREBBP and EP300 are frequent and early events in the pathogenesis of FL and DLBCL, the two most common lymphoma subtypes. Meyer et al. uncover distinct as well as compensatory roles for these acetyltransferases in separate compartments of the germinal center and exploit this notion to document an EP300-dependency in CREBBP-deficient lymphoma cells that can be targeted therapeutically.
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