A human germline-mosaic for WT and DNMT3A mutant cells reveals a marked advantage for DNMT3A mutant cells in the hematopoietic system compared to epithelial cells. Deep sequencing suggests a very early tissue advantage driven by DNA methylation loss at conserved loci rather than increased mutation burden.

Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion

Brunetti L.;
2020

Abstract

A human germline-mosaic for WT and DNMT3A mutant cells reveals a marked advantage for DNMT3A mutant cells in the hematopoietic system compared to epithelial cells. Deep sequencing suggests a very early tissue advantage driven by DNA methylation loss at conserved loci rather than increased mutation burden.
2020
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1475148
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