The synthetic immunomodulator cytotoxic T lymphocyte antigen 4-Ig (CTLA-4-Ig) initiates effects in human monocyte-derived dendritic cells (DC) that rely on immunosuppressive tryptophan catabolism. However, it is unable to induce suppressive properties in DC matured by CD40 engagement. Thus, CD40-driven events may physiologically set human DC free from restraint by regulatory cells expressing surface CTLA-4.
CD40 ligation prevents onset of tolerogenic properties in human dendritic cells treated with CTLA-4-Ig.
VACCA, Carmine;FALLARINO, Francesca;PERRUCCIO, Katia;ORABONA, Ciriana;BIANCHI, Roberta;GIZZI, STEFANIA;VELARDI, Andrea;FIORETTI, Maria Cristina;PUCCETTI, Paolo;GROHMANN, Ursula
2005
Abstract
The synthetic immunomodulator cytotoxic T lymphocyte antigen 4-Ig (CTLA-4-Ig) initiates effects in human monocyte-derived dendritic cells (DC) that rely on immunosuppressive tryptophan catabolism. However, it is unable to induce suppressive properties in DC matured by CD40 engagement. Thus, CD40-driven events may physiologically set human DC free from restraint by regulatory cells expressing surface CTLA-4.File in questo prodotto:
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