We assessed the effect of rIL-12 on the expression of class II molecules and on the ratio between SDS-stable and unstable alphabeta dimers in dendritic cells. We found that in vitro exposure of the cells to IL-12 increased their surface expression of mature class II molecules, despite a marked decline in class II biosynthesis. This effect was accompanied by a striking increase in the overall proportion of SDS-stable heterodimers.
IL-12 induces SDS-stable class II (alpha beta) dimers in murine dendritic cells
GROHMANN, Ursula;ORABONA, Ciriana;BIANCHI, Roberta;BELLADONNA, Maria Laura;FIORETTI, Maria Cristina;PUCCETTI, Paolo
2000
Abstract
We assessed the effect of rIL-12 on the expression of class II molecules and on the ratio between SDS-stable and unstable alphabeta dimers in dendritic cells. We found that in vitro exposure of the cells to IL-12 increased their surface expression of mature class II molecules, despite a marked decline in class II biosynthesis. This effect was accompanied by a striking increase in the overall proportion of SDS-stable heterodimers.File in questo prodotto:
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