Secretion of the lysosomal enzyme hexosaminidase is induced by amphotericin B in mouse spleen adherent cells that show a significant increase in their candidacidal activity. The stimulation of beta-hexosaminidase is both time and dose dependent. Amphotericin B treatment did not change hexosaminidase expression that is represented mainly by "A-type" hexosaminidase in macrophages, on the basis of its biochemical properties.

Amphotericin B stimulates secretion of β-hexosaminidase from mouse adherent spleen cells

BECCARI, Tommaso;MAZZOLLA, Rosanna;DATTI, Alessandro;BARLUZZI, Roberta;BISTONI, Francesco;ORLACCHIO, Aldo
1991-01-01

Abstract

Secretion of the lysosomal enzyme hexosaminidase is induced by amphotericin B in mouse spleen adherent cells that show a significant increase in their candidacidal activity. The stimulation of beta-hexosaminidase is both time and dose dependent. Amphotericin B treatment did not change hexosaminidase expression that is represented mainly by "A-type" hexosaminidase in macrophages, on the basis of its biochemical properties.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/157335
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