Nitrile-containing drugs represent an important class of natural and pharmaceutical compounds, exhibiting diverse biological activities across multiple therapeutic areas. The incorporation of a nitrile functional group in drug molecules influences their pharmacokinetic properties, bioavailability, and metabolic stability. This review provides a comprehensive analysis of the role of nitrile groups in drug design, their pharmacological significance, and the key synthetic strategies used for the development of the eleven FDA-approved nitrile-containing drugs from 2021 to 2024.
The importance of nitrile functionality: FDA-approved small molecules from 2021 to 2024
Benedetto Tiz, Davide
;Mangiavacchi, Francesca;Sancineto, Luca
2026
Abstract
Nitrile-containing drugs represent an important class of natural and pharmaceutical compounds, exhibiting diverse biological activities across multiple therapeutic areas. The incorporation of a nitrile functional group in drug molecules influences their pharmacokinetic properties, bioavailability, and metabolic stability. This review provides a comprehensive analysis of the role of nitrile groups in drug design, their pharmacological significance, and the key synthetic strategies used for the development of the eleven FDA-approved nitrile-containing drugs from 2021 to 2024.File in questo prodotto:
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