IRIS - Res&Arch Institutional Research Information System - Research & Archive

MACCHIARULO, Antonio
 Distribuzione geografica
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Continente #
NA - Nord America 5.766
EU - Europa 4.762
AS - Asia 1.831
AF - Africa 16
Continente sconosciuto - Info sul continente non disponibili 10
SA - Sud America 9
OC - Oceania 2
Totale 12.396
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Nazione #
US - Stati Uniti d'America 5.740
IE - Irlanda 1.000
UA - Ucraina 908
IT - Italia 903
SG - Singapore 749
SE - Svezia 654
HK - Hong Kong 431
DE - Germania 285
CN - Cina 253
FI - Finlandia 235
VN - Vietnam 218
RU - Federazione Russa 196
FR - Francia 125
RO - Romania 105
GB - Regno Unito 104
TR - Turchia 65
KR - Corea 61
BE - Belgio 57
CZ - Repubblica Ceca 42
CH - Svizzera 34
NL - Olanda 29
GR - Grecia 21
PL - Polonia 20
AT - Austria 16
UZ - Uzbekistan 16
MX - Messico 14
CA - Canada 10
EU - Europa 10
LB - Libano 10
EG - Egitto 9
JP - Giappone 9
BG - Bulgaria 7
IL - Israele 7
CI - Costa d'Avorio 6
ES - Italia 5
BR - Brasile 4
NO - Norvegia 3
PT - Portogallo 3
AM - Armenia 2
AR - Argentina 2
BD - Bangladesh 2
MD - Moldavia 2
MY - Malesia 2
NZ - Nuova Zelanda 2
SK - Slovacchia (Repubblica Slovacca) 2
CL - Cile 1
CO - Colombia 1
DK - Danimarca 1
HR - Croazia 1
HU - Ungheria 1
IN - India 1
IR - Iran 1
JM - Giamaica 1
LA - Repubblica Popolare Democratica del Laos 1
LU - Lussemburgo 1
LV - Lettonia 1
MA - Marocco 1
MC - Monaco 1
PA - Panama 1
PE - Perù 1
PH - Filippine 1
QA - Qatar 1
TW - Taiwan 1
Totale 12.396
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Città #
Chandler 1.079
Dublin 998
Singapore 609
San Mateo 506
Jacksonville 493
Hong Kong 427
Boardman 374
Perugia 340
Santa Clara 292
Medford 238
Princeton 235
Altamura 225
Dong Ket 217
Wilmington 201
Lawrence 165
Ann Arbor 154
Andover 148
Redmond 131
Bucharest 92
Beijing 89
Des Moines 74
Izmir 63
Saint Petersburg 60
Brussels 55
Woodbridge 52
Ashburn 50
Norwalk 41
Seoul 41
Los Angeles 39
Falls Church 35
San Paolo di Civitate 34
Helsinki 32
Auburn Hills 26
Pisa 26
Redwood City 25
Munich 23
Moscow 22
New York 22
Rome 20
Brno 19
Dallas 19
Shanghai 18
Olomouc 17
Den Haag 15
Dearborn 14
Chicago 11
Frankfurt Am Main 11
Mcallen 11
Florence 10
Saronno 10
Spoleto 10
West Jordan 10
Cairo 9
Chiajna 9
Guangzhou 8
Hanover 8
Milan 8
Ottawa 8
Simi Valley 8
Boydton 7
Houston 7
Abidjan 6
Assisi 6
Falkenstein 6
Fremont 6
Kraków 6
Ness Ziona 6
Renton 6
San Diego 6
Tokyo 6
Bologna 5
Lappeenranta 5
Misano Adriatico 5
Philadelphia 5
Saint Louis 5
Tappahannock 5
Vienna 5
Lausanne 4
Macerata 4
Montefalco 4
Nanjing 4
San Giustino 4
Terni 4
Washington 4
Winston-Salem 4
Wuhan 4
Cassino 3
Esslingen am Neckar 3
Frankfurt am Main 3
Groningen 3
Ludwigshafen 3
Madrid 3
Nagold 3
Palermo 3
Rieti 3
Stockholm 3
Timisoara 3
Torgiano 3
Torino 3
Vicenza 3
Totale 8.167
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Nome #
1,4 Benzothiazine and 1,4 benzoxazine imidazole derivatives with antifungal activity: a docking study 243
Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1. 130
Class IA PI3Ks regulate subcellular and functional dynamics of IDO1 128
A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells 124
Aryl hydrocarbon receptor control of a disease tolerance defence pathway. 122
Computational studies in enantioselective liquid chromatography: Forty years of evolution in docking- and molecular dynamics-based simulations 121
Identification of a 2-propanol analogue modulating the non-enzymatic function of indoleamine 2,3-dioxygenase 1 112
Binding Mode and Structure-Activity Relationships of ITE as an Aryl Hydrocarbon Receptor (AhR) Agonist 106
Insights into the molecular function of the inactivating mutations of B-Raf involving the DFG motif 103
Genotyping of an Italian papillary thyroid carcinoma cohort revealed high prevalence of BRAF mutations, absence of RAS mutations and allowed the detection of a new mutation of BRAF oncoprotein (BRAF). 102
Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry 101
Avicholic Acid: A Primary Bile Acid from Birds on the Route to Potent and Selective TGR5 Ligands 96
Fragment-based approach to identify IDO1 inhibitor building blocks 94
87P - Towards the identification of the mechanism of action of antitumor 1-methyl-D-tryptophan 87
Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1 85
Structure of Metal-Carbenoid Intermediates Derived from the Dirhodium(II)Tetracarboxylate Mediated Decomposition of ?-Diazocarbonyl Compounds. An ab initio and DTF Study 84
Glucocorticoid-induced leucine zipper (GILZ)/NF-kB interaction: role of GILZ homo-dimerization and C-terminal domain 84
Towards New Neuroprotective Agents: Design and Synthesis of Thieno[2,3-c]-isoquinolinon-5-one as a Potent PARP-1 Inhibitor. 81
Preclinical discovery and development of fingolimod for the treatment of multiple sclerosis 81
Analisi del meccanismo dominante inibitorio esercitato in cis dalle mutazioni inattivanti D594V e G596R sulla mutazione attivante di BRAF V600E 80
Spiro[2.2]pentane as a Dissymmetric Scaffold for Conformationally Constrained Analogues of Glutamic Acid: Focus on Racemic 1-Aminospiro[2.2]pentyl-1,4-dicarboxylic Acids 79
D-leucine microparticles as an excipient to improve the aerosolization performances of dry powders for inhalation 79
Design, Synthesis and Preliminay Evaluation of Novel 3’-Substituted Carboxycyclopropylglycines as Antagonists at Group 2 Metabotropic Glutamate Receptors 78
Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5. 77
Adamantyl-substituted retinoid-derived molecules that intercact with the orphan nuclear receptor small heterodimer partner:effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity 77
Oxime and Oxime Ether Derivatives of 1,4-Benzothiazine Related to Oxiconazole. 77
Spiro[2.2]pentane as a dyssymetric scaffold for conformationally constrained analogues of glutamic acid: diastereodivergent synthesis of 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids 77
Evaluation of the enantiomeric selectivity in the Chiral Ligand-Exchange Chromatography of amino acids by a computational model 76
Caratterizzazione biochimica e molecolare della nuova mutazione BRAFV599Ins recentemente individuata in un carcinoma papillare della tiroide 75
Design and synthesis of 4H-thieno[2,3-c]isoquinolin-5-one derivatives as potent PARP-1 inhibitors, on route of new antiischemic agents 75
Metabotropic glutamate receptors: structure and new subtype-selective ligands 74
Protective effects of Commiphora erythraea resin constituents against cellular oxidative damage 74
Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure-Activity Relationships and Molecular Modeling Studies 73
Tracking Hidden Binding Pockets Along the Molecular Recognition Path of l-Trp to Indoleamine 2,3-Dioxygenase 1 73
Insights into Phenylalanine Derivatives Recognition of VLA-4 Integrin: from a Pharmacophoric Study to 3D-QSAR and Molecular Docking Analyses 72
Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs. 71
Discovery of 6α-Ethyl-23(S)-methyl-cholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity 71
Alternative strategies for targeting mouse double minute 2 activity with small molecules: novel patents on the horizon? 71
Insights into the molecular function of the inactivating mutations of B-Raf involving the DFG motif. 70
PARP inhibitors: polypharmacology versus selective inhibition 70
AhR-Mediated, Non-Genomic Modulation of IDO1 Function 70
Integrated Fragment-Based Approaches on the Route to Novel IDO1 Modulators 70
Side chain modified HDCA derivatives: synthesis, CMC determination and molecular modelling studies. 69
9. The Systems Biology of Transporters – Targeting the Regulatory System for Transporters (FXR/RXR) 69
Binding Mode of 6ECDCA, a Potent Bile Acid Agonist of the Farnesoid X Receptor (FXR) 68
Sequence variants in kynurenine aminotransferase II (KAT II) orthologs determine different potencies of the inhibitor S-ESBA 68
Molecular dynamic simulations of the catalytic domain of BRAF in response to activating and inactivating mutations 67
A novel mutation of indoleamine 2,3-dioxygenase 1 causes a rapid proteasomal degradation and compromises protein function 67
S-Trityl-(R)-cysteine, a powerful chiral selector for the analytical and preparative ligand-exchange chromatography of amino acids 66
Homology Modeling of AMPA Receptors: Route to the identification of noncompetitive antagonists binding site 66
Synthesis, Molecular modeling studies and preliminary pharmacological characterization of all the eight possible 2-(2'sulfonocylcopropyl)glycine stereoisomers, as conformationally constrined L-homocysteic acid analogs 66
Avicholic acid: a lead compound from birds on the route to potent TGR5 modulators 66
Ligand Binding and Functional Selectivity ofl-Tryptophan Metabolites at the Mouse Aryl Hydrocarbon Receptor (mAhR) 66
Binding properties of different categories of IDO1 inhibitors: A microscale thermophoresis study 66
(S)-(-)-alpha,alpha-Di(2-naphthyl)-2-pyrrolidine Methanol, a Useful Tool to Study the Recognition Mechanism in Chiral Ligand-Exchange Chromatography (CLEC) 65
Rat Brain Guanosine Binding Site:Biological Studies and Pseudo Receptor Construction 65
Design, Synthesis, and Microbiolgical Evaluation of New Candida albicans CYP51 Inhibitors 65
Targeting the FXR nuclear receptor through a virtual screening approach 65
1μs Molecular Dynamics Simulations to study the poisoning effect of the PARP-1 full length enzyme 65
Le sostituzioni aminoacidiche G596R e D594V hanno un effetto inibitorio dominante sulla funzione della mutazione V600E di BRAF 64
Metabotropic Glutamate Receptors: A Structural View Point 63
Bulky 1,4-benzoxazine derivatives with antifungal activity 63
Novel ketoconazole analogues based on the replacement of 2,4-dichlorophenyl group with 1,4-benzothiazine moiety: design, synthesis, and microbiological evaluation 62
A new computational model to predict the elution order in the chiral ligand-exchange chromatography (CLEC) of amino acids 62
Targeting the FXR Nuclear Receptor through a Virtual Screening Approach 62
Targeting the MDM2/MDM4 Interaction Interface as a Promising Approach for p53 Reactivation Therapy 62
(S)-(-)-a,a-Di(2-naphthyl)-2-pyrrolidine Methanol, a useful tool to study the recognition mechanism in chiral ligand-exchange chromatography (CLEC) 61
Binding modes of noncompetitive AMPA Antagonists: A computational approach 60
Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ 60
Cyclopropyl Dafachronic Acid Stereoisomers as Conformationally Constrained DAF-12 Ligands 60
New Insights from Crystallographic Data: Diversity of Structural Motifs and Molecular Recognition Properties between Groups of IDO1 Structures 60
Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy. 59
INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IS UPREGULATED IN THYROID CARCINOMA AND DRIVES THE DEVELOPMENT OF AN IMMUNOSUPPRESSANT TUMOR MICROENVIRONMENT. 59
Chromatographic hydrophobicity index: a high-throughput tool to estimate the critical micellar concentration of bile acids 58
Integrating Multicomponent Flow Synthesis and Computational Approaches for the Generation of a Tetrahydroquinoline Compound Based Library 58
Expanding the horizon of chemotherapeutic targets: From MDM2 to MDMX (MDM4). 57
Bile Acid Derivatives as Ligands of the Farnesoid X Receptor: Molecular Determinants for Bile Acid Binding and Receptor Modulation 57
Elucidation of the chromatographic enantiomer elution order through computational studies 57
Beyond Bile Acids: Targeting Farnesoid X Receptor (FXR) with Natural and Synthetic Ligands 57
The effect of the copper(II) salt anion in the Chiral Ligand-Exchange Chromatography of amino acids 57
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine 57
Derived chromatographic indices as effective tools to study the self-aggregation process of bile acids 56
Discovery of 3α,7α,11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid (TC-100), a Novel Bile Acid as Potent and Highly Selective FXR Agonist for Enterohepatic Disorders 56
VERY LONG CHAIN FATTY ACID SPHINGOMYELIN IN NUCLEAR LIPID MICRODOMAINS OF HEPATOCYTES AND HEPATOMA CELLS: CAN THE EXCHANGE FROM C24:0 TO C16:0 AFFECT SIGNAL PROTEINS AND VITAMIN D RECEPTOR? 56
Modeling of Poly(ADP-ribose)polymerase (PARP) Inhibitors. Docking of Ligands and QSAR 55
Unveiling hidden features of orphan nuclear receptors: The case of the small heterodimer partner (SHP). 55
Molecular docking and spatial coarse graining simulations as tools to investigate substrate recognition, enhancer binding and conformational transitions in indoleamine-2,3-dioxygenase (IDO). 55
Molecular dynamics simulation of the ligand binding domain of mGluR1 in response to agonist and antagonist binding. 55
Unravelling the molecular basis for DAF-12 activation: diastereoselective synthesis and SAR studies of dafachronic acid derivatives. 55
The Janus-faced nature of IDO1 in infectious diseases: Challenges and therapeutic opportunities 55
Exploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists 55
Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation 55
Microscale thermophoresis and docking studies suggest lapachol and auraptene are ligands of IDO1 55
Bile acids: property-activity relationship and molecular modelling studies 54
Targeting the conformational transitions of MDM2 and MDMX: insights into dissimilarities and similarities of p53 recognition. 53
Quantum mechanics/molecular mechanics (QM/MM) modeling of the irreversible transamination of L-kynurenine to kynurenic acid: The round dance of kynurenine aminotransferase II 53
Chiral ligand-exchange separation and resolution of extremely rigid glutamate analogues: 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids 53
A general partnership between AhR and tryptophan catabolic enzymes and its role in endotoxin tolerance 53
Optimized one-pot derivatization and enantioseparation of cysteine: Application to the study of a dietary supplement 53
Phenolic acids from Lycium barbarum leaves: In vitro and in silico studies of the inhibitory activity against porcine pancreatic α-amylase 53
Totale 7.272
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Categoria #
all - tutte 56.969
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 56.969
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020651 0 0 0 0 0 26 159 35 175 143 27 86
2020/20212.098 13 149 79 141 622 134 164 36 265 81 157 257
2021/20222.140 49 326 39 132 59 34 18 638 113 142 238 352
2022/20233.543 256 630 43 272 329 374 7 147 1.288 27 131 39
2023/20241.595 129 200 74 22 13 20 283 51 201 51 233 318
2024/20251.387 59 336 195 165 435 197 0 0 0 0 0 0
Totale 13.092