IRIS - Res&Arch Institutional Research Information System - Research & Archive

MACCHIARULO, Antonio
 Distribuzione geografica
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Continente #
NA - Nord America 9.096
EU - Europa 6.774
AS - Asia 6.421
SA - Sud America 1.085
Continente sconosciuto - Info sul continente non disponibili 743
AF - Africa 187
OC - Oceania 10
Totale 24.316
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Nazione #
US - Stati Uniti d'America 8.857
SG - Singapore 2.989
IT - Italia 1.335
IE - Irlanda 996
UA - Ucraina 918
CN - Cina 859
RU - Federazione Russa 844
HK - Hong Kong 833
BR - Brasile 831
SE - Svezia 682
VN - Vietnam 600
DE - Germania 494
FR - Francia 390
FI - Finlandia 310
KR - Corea 240
GB - Regno Unito 230
IN - India 154
BD - Bangladesh 149
TR - Turchia 124
RO - Romania 118
CA - Canada 111
AR - Argentina 95
NL - Olanda 71
MX - Messico 70
PL - Polonia 64
BE - Belgio 58
JP - Giappone 57
IQ - Iraq 54
UZ - Uzbekistan 52
CO - Colombia 50
CZ - Repubblica Ceca 50
ZA - Sudafrica 48
ID - Indonesia 40
PK - Pakistan 39
AT - Austria 38
CH - Svizzera 36
ES - Italia 35
EC - Ecuador 32
PH - Filippine 31
JO - Giordania 28
VE - Venezuela 28
SA - Arabia Saudita 25
GR - Grecia 23
LT - Lituania 20
EG - Egitto 19
TN - Tunisia 18
MA - Marocco 17
ET - Etiopia 15
LB - Libano 15
JM - Giamaica 14
MY - Malesia 14
PE - Perù 14
AE - Emirati Arabi Uniti 13
CR - Costa Rica 13
CL - Cile 12
IL - Israele 12
PY - Paraguay 12
DZ - Algeria 11
KE - Kenya 11
EU - Europa 10
NP - Nepal 10
AZ - Azerbaigian 9
BG - Bulgaria 9
CI - Costa d'Avorio 8
MD - Moldavia 8
KZ - Kazakistan 7
NO - Norvegia 7
OM - Oman 7
AO - Angola 6
KG - Kirghizistan 6
TH - Thailandia 6
TT - Trinidad e Tobago 6
AM - Armenia 5
AU - Australia 5
DK - Danimarca 5
GE - Georgia 5
PT - Portogallo 5
QA - Qatar 5
SN - Senegal 5
DO - Repubblica Dominicana 4
IR - Iran 4
KW - Kuwait 4
LA - Repubblica Popolare Democratica del Laos 4
LY - Libia 4
NZ - Nuova Zelanda 4
PS - Palestinian Territory 4
RS - Serbia 4
SK - Slovacchia (Repubblica Slovacca) 4
UY - Uruguay 4
AL - Albania 3
BB - Barbados 3
BF - Burkina Faso 3
GT - Guatemala 3
HU - Ungheria 3
LV - Lettonia 3
NG - Nigeria 3
NI - Nicaragua 3
PA - Panama 3
PR - Porto Rico 3
SR - Suriname 3
Totale 23.525
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Città #
Singapore 2.125
Chandler 1.069
Dublin 994
San Jose 835
Hong Kong 823
Perugia 564
Ashburn 558
San Mateo 503
Jacksonville 491
Santa Clara 386
Boardman 373
Moscow 308
Medford 237
Princeton 234
Lauterbourg 230
Altamura 223
Seoul 220
Dong Ket 217
Beijing 213
Wilmington 200
Los Angeles 171
Munich 167
Lawrence 164
Ann Arbor 153
Andover 148
New York 147
Redmond 131
Ho Chi Minh City 121
Bucharest 93
The Dalles 90
Hanoi 83
Piscataway 83
São Paulo 78
Des Moines 75
Izmir 64
Orem 63
Saint Petersburg 60
Phoenix 58
Brussels 56
Dallas 54
Woodbridge 52
Turku 51
Helsinki 48
Tokyo 48
Chennai 47
Rome 45
Warsaw 43
Norwalk 41
Chicago 40
Falls Church 35
Montreal 35
Nuremberg 35
San Paolo di Civitate 34
Houston 33
Shanghai 33
Tashkent 33
Council Bluffs 32
Stockholm 30
Denver 29
Johannesburg 29
Atlanta 27
Brooklyn 27
Auburn Hills 26
Pisa 26
San Francisco 26
London 25
Poplar 25
Redwood City 25
Amman 24
Manchester 24
Mexico City 24
Buffalo 23
Baghdad 22
Olomouc 22
Belo Horizonte 21
Columbus 21
Rio de Janeiro 21
Amsterdam 20
Brno 20
Haiphong 20
Toronto 20
Boston 19
Frankfurt am Main 19
Ankara 18
Hefei 18
Milan 18
Brasília 17
Seattle 17
Da Nang 16
Medellín 16
Addis Ababa 15
Den Haag 15
New Delhi 15
Cairo 14
Campinas 14
Dearborn 14
Guangzhou 14
Lahore 14
Philadelphia 14
Bologna 13
Totale 14.424
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Nome #
1,4 Benzothiazine and 1,4 benzoxazine imidazole derivatives with antifungal activity: a docking study 327
Class IA PI3Ks regulate subcellular and functional dynamics of IDO1 213
A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells 202
Aryl hydrocarbon receptor control of a disease tolerance defence pathway. 190
Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1. 184
Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry 182
Identification of a 2-propanol analogue modulating the non-enzymatic function of indoleamine 2,3-dioxygenase 1 175
Binding Mode and Structure-Activity Relationships of ITE as an Aryl Hydrocarbon Receptor (AhR) Agonist 172
Computational studies in enantioselective liquid chromatography: Forty years of evolution in docking- and molecular dynamics-based simulations 164
Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation 162
87P - Towards the identification of the mechanism of action of antitumor 1-methyl-D-tryptophan 162
Fragment-based approach to identify IDO1 inhibitor building blocks 157
Genotyping of an Italian papillary thyroid carcinoma cohort revealed high prevalence of BRAF mutations, absence of RAS mutations and allowed the detection of a new mutation of BRAF oncoprotein (BRAF). 152
Insights into the molecular function of the inactivating mutations of B-Raf involving the DFG motif 151
A back-door insight into the modulation of Src kinase activity by the polyamine spermidine 148
A novel mutation of indoleamine 2,3-dioxygenase 1 causes a rapid proteasomal degradation and compromises protein function 148
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine 145
Natural cellulosic biofunctional textiles from onion (Allium cepa L.) skin extracts: a sustainable strategy for skin protection 143
9. The Systems Biology of Transporters – Targeting the Regulatory System for Transporters (FXR/RXR) 143
Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5. 140
Critical Assessment of a Structure-Based Screening Campaign for IDO1 Inhibitors: Tips and Pitfalls 137
Glucocorticoid-induced leucine zipper (GILZ)/NF-kB interaction: role of GILZ homo-dimerization and C-terminal domain 136
Tracking Hidden Binding Pockets Along the Molecular Recognition Path of l-Trp to Indoleamine 2,3-Dioxygenase 1 136
Avicholic Acid: A Primary Bile Acid from Birds on the Route to Potent and Selective TGR5 Ligands 135
Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1 132
Adamantyl-substituted retinoid-derived molecules that intercact with the orphan nuclear receptor small heterodimer partner:effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity 132
Integrated Fragment-Based Approaches on the Route to Novel IDO1 Modulators 132
Analisi del meccanismo dominante inibitorio esercitato in cis dalle mutazioni inattivanti D594V e G596R sulla mutazione attivante di BRAF V600E 131
D-leucine microparticles as an excipient to improve the aerosolization performances of dry powders for inhalation 130
(S)-(-)-alpha,alpha-Di(2-naphthyl)-2-pyrrolidine Methanol, a Useful Tool to Study the Recognition Mechanism in Chiral Ligand-Exchange Chromatography (CLEC) 128
New Insights from Crystallographic Data: Diversity of Structural Motifs and Molecular Recognition Properties between Groups of IDO1 Structures 128
Chiral mobile phase in ligand-exchange chromatography of amino acids: Exploring the copper(II) salt anion effect with a computational approach 127
Enantioselective HPLC analysis to assist the chemical exploration of chiral imidazolines 127
PROTACs bearing piperazine-containing linkers: what effect on their protonation state? 126
Design, synthesis, and biological evaluation of first-in-class indomethacin-based PROTACs degrading SARS-CoV-2 main protease and with broad-spectrum antiviral activity 124
Preclinical discovery and development of fingolimod for the treatment of multiple sclerosis 124
Epacadostat stabilizes the apo-form of IDO1 and signals a pro-tumorigenic pathway in human ovarian cancer cells 123
Binding Mode of 6ECDCA, a Potent Bile Acid Agonist of the Farnesoid X Receptor (FXR) 123
(S)-(-)-a,a-Di(2-naphthyl)-2-pyrrolidine Methanol, a useful tool to study the recognition mechanism in chiral ligand-exchange chromatography (CLEC) 123
Alternative strategies for targeting mouse double minute 2 activity with small molecules: novel patents on the horizon? 122
AhR-Mediated, Non-Genomic Modulation of IDO1 Function 122
Binding properties of different categories of IDO1 inhibitors: A microscale thermophoresis study 122
Optimized one-pot derivatization and enantioseparation of cysteine: Application to the study of a dietary supplement 121
Spiro[2.2]pentane as a Dissymmetric Scaffold for Conformationally Constrained Analogues of Glutamic Acid: Focus on Racemic 1-Aminospiro[2.2]pentyl-1,4-dicarboxylic Acids 120
A new computational model to predict the elution order in the chiral ligand-exchange chromatography (CLEC) of amino acids 120
Side chain modified HDCA derivatives: synthesis, CMC determination and molecular modelling studies. 120
Structure of Metal-Carbenoid Intermediates Derived from the Dirhodium(II)Tetracarboxylate Mediated Decomposition of ?-Diazocarbonyl Compounds. An ab initio and DTF Study 119
Bulky 1,4-benzoxazine derivatives with antifungal activity 119
Towards New Neuroprotective Agents: Design and Synthesis of Thieno[2,3-c]-isoquinolinon-5-one as a Potent PARP-1 Inhibitor. 118
1μs Molecular Dynamics Simulations to study the poisoning effect of the PARP-1 full length enzyme 118
Microscale thermophoresis and docking studies suggest lapachol and auraptene are ligands of IDO1 118
Insights into Phenylalanine Derivatives Recognition of VLA-4 Integrin: from a Pharmacophoric Study to 3D-QSAR and Molecular Docking Analyses 117
Targeting Aryl hydrocarbon receptor for next-generation immunotherapies: Selective modulators (SAhRMs) versus rapidly metabolized ligands (RMAhRLs) 117
Spiro[2.2]pentane as a dyssymetric scaffold for conformationally constrained analogues of glutamic acid: diastereodivergent synthesis of 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids 116
Cyclopropyl Dafachronic Acid Stereoisomers as Conformationally Constrained DAF-12 Ligands 116
Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure-Activity Relationships and Molecular Modeling Studies 115
Taxifolin and gastro-adhesive microparticles containing taxifolin promotes gastric healing in vivo, inhibits Helicobacter pylori in vitro and proton pump reversibly in silico 114
Design, Synthesis and Preliminay Evaluation of Novel 3’-Substituted Carboxycyclopropylglycines as Antagonists at Group 2 Metabotropic Glutamate Receptors 113
The Stone Guest: How Does pH Affect Binding Properties of PD-1/PD-L1 Inhibitors? 113
Design, Synthesis, and Microbiolgical Evaluation of New Candida albicans CYP51 Inhibitors 112
Protective effects of Commiphora erythraea resin constituents against cellular oxidative damage 112
Metabotropic glutamate receptors: structure and new subtype-selective ligands 111
Targeting the FXR nuclear receptor through a virtual screening approach 111
Estimating the hydrophobicity extent of molecular fragments using reversed‐phase liquid chromatography 110
Phenolic acids from Lycium barbarum leaves: In vitro and in silico studies of the inhibitory activity against porcine pancreatic α-amylase 110
Turning a Tumor Microenvironment Pitfall into Opportunity: Discovery of Benzamidoxime as PD-L1 Ligand with pH-Dependent Potency 109
Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs. 109
Caratterizzazione biochimica e molecolare della nuova mutazione BRAFV599Ins recentemente individuata in un carcinoma papillare della tiroide 109
Beyond Bile Acids: Targeting Farnesoid X Receptor (FXR) with Natural and Synthetic Ligands 109
One Key and Multiple Locks: Substrate Binding in Structures of Tryptophan Dioxygenases and Hydroxylases 109
Insights into the molecular function of the inactivating mutations of B-Raf involving the DFG motif. 108
Fragment based drug design and diversity-oriented synthesis of carboxylic acid isosteres 108
Molecular dynamic simulations of the catalytic domain of BRAF in response to activating and inactivating mutations 107
Avicholic acid: a lead compound from birds on the route to potent TGR5 modulators 107
Design and synthesis of 4H-thieno[2,3-c]isoquinolin-5-one derivatives as potent PARP-1 inhibitors, on route of new antiischemic agents 107
Lead optimization-hit expansion of new asymmetrical pyridinium/quinolinium compounds as choline kinase α1 inhibitors 107
Dynamic Ligand-Exchange Chiral Stationary Phase from S-Benzyl-(R)-cysteine 106
Chromatographic hydrophobicity index: a high-throughput tool to estimate the critical micellar concentration of bile acids 106
Exploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists 106
Homology Modeling of AMPA Receptors: Route to the identification of noncompetitive antagonists binding site 105
PARP inhibitors: polypharmacology versus selective inhibition 105
Bile Acid Derivatives as Ligands of the Farnesoid X Receptor: Molecular Determinants for Bile Acid Binding and Receptor Modulation 105
VERY LONG CHAIN FATTY ACID SPHINGOMYELIN IN NUCLEAR LIPID MICRODOMAINS OF HEPATOCYTES AND HEPATOMA CELLS: CAN THE EXCHANGE FROM C24:0 TO C16:0 AFFECT SIGNAL PROTEINS AND VITAMIN D RECEPTOR? 105
Targeting Wnt-driven cancers: Discovery of novel tankyrase inhibitors 105
Elucidation of the chromatographic enantiomer elution order through computational studies 104
Discovery of 6α-Ethyl-23(S)-methyl-cholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity 103
Ligand Binding and Functional Selectivity ofl-Tryptophan Metabolites at the Mouse Aryl Hydrocarbon Receptor (mAhR) 103
Sequence variants in kynurenine aminotransferase II (KAT II) orthologs determine different potencies of the inhibitor S-ESBA 103
Unravelling the molecular basis for DAF-12 activation: diastereoselective synthesis and SAR studies of dafachronic acid derivatives. 102
A microbially produced AhR ligand promotes a Tph1-driven tolerogenic program in multiple sclerosis 101
Binding modes of noncompetitive AMPA Antagonists: A computational approach 100
Chiral ligand-exchange separation and resolution ofextremely rigid glutamate analogs: 1-aminospiro[2.2]pentyl-1,4-dicarboxylicacids. 100
Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy. 100
INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IS UPREGULATED IN THYROID CARCINOMA AND DRIVES THE DEVELOPMENT OF AN IMMUNOSUPPRESSANT TUMOR MICROENVIRONMENT. 100
The Janus-faced nature of IDO1 in infectious diseases: Challenges and therapeutic opportunities 100
A general partnership between AhR and tryptophan catabolic enzymes and its role in endotoxin tolerance 100
Glucocorticoid Induced Leucine Zipper (GILZ) inhibits the RAF-ERK pathway by binding to RAF-1 100
Modeling of Poly(ADP-ribose)polymerase (PARP) Inhibitors. Docking of Ligands and QSAR 99
Evaluation of the enantiomeric selectivity in the Chiral Ligand-Exchange Chromatography of amino acids by a computational model 99
The signaling function of IDO1 incites the malignant progression of mouse B16 melanoma 98
Totale 12.584
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Categoria #
all - tutte 108.771
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 108.771
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.757 0 0 37 132 58 34 18 636 113 142 236 351
2022/20233.517 255 625 43 269 327 371 7 147 1.280 27 127 39
2023/20241.589 129 199 74 21 13 20 283 51 199 51 232 317
2024/20253.906 58 335 193 164 434 220 233 296 753 211 656 353
2025/20268.134 569 644 396 972 1.070 739 1.380 430 897 665 248 124
2026/2027641 173 307 161 0 0 0 0 0 0 0 0 0
Totale 24.316