IRIS - Res&Arch Institutional Research Information System - Research & Archive

MACCHIARULO, Antonio
 Distribuzione geografica
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Continente #
NA - Nord America 4.958
EU - Europa 4.599
AS - Asia 932
AF - Africa 12
Continente sconosciuto - Info sul continente non disponibili 10
SA - Sud America 5
OC - Oceania 2
Totale 10.518
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Nazione #
US - Stati Uniti d'America 4.939
IE - Irlanda 1.000
UA - Ucraina 908
IT - Italia 862
SE - Svezia 653
HK - Hong Kong 430
DE - Germania 257
FI - Finlandia 224
VN - Vietnam 217
RU - Federazione Russa 193
CN - Cina 121
FR - Francia 117
GB - Regno Unito 98
RO - Romania 95
TR - Turchia 64
BE - Belgio 57
CH - Svizzera 34
SG - Singapore 30
KR - Corea 24
NL - Olanda 22
GR - Grecia 21
PL - Polonia 19
UZ - Uzbekistan 16
AT - Austria 14
MX - Messico 14
EU - Europa 10
LB - Libano 10
JP - Giappone 9
BG - Bulgaria 7
EG - Egitto 7
IL - Israele 7
CZ - Repubblica Ceca 6
CA - Canada 5
CI - Costa d'Avorio 5
BR - Brasile 3
NO - Norvegia 3
ES - Italia 2
MY - Malesia 2
NZ - Nuova Zelanda 2
SK - Slovacchia (Repubblica Slovacca) 2
BD - Bangladesh 1
CL - Cile 1
CO - Colombia 1
HR - Croazia 1
HU - Ungheria 1
IR - Iran 1
LV - Lettonia 1
MC - Monaco 1
MD - Moldavia 1
Totale 10.518
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Città #
Chandler 1.079
Dublin 998
San Mateo 506
Jacksonville 493
Hong Kong 426
Perugia 323
Medford 238
Princeton 235
Altamura 225
Dong Ket 217
Wilmington 201
Lawrence 165
Ann Arbor 154
Andover 148
Redmond 131
Bucharest 92
Beijing 87
Des Moines 74
Izmir 63
Saint Petersburg 60
Brussels 55
Woodbridge 52
Boardman 44
Norwalk 41
Falls Church 35
San Paolo di Civitate 34
Los Angeles 32
Ashburn 30
Auburn Hills 26
Pisa 26
Redwood City 25
Helsinki 22
New York 22
Moscow 19
Singapore 17
Rome 16
Den Haag 15
Dearborn 14
Chicago 11
Frankfurt Am Main 11
Mcallen 11
Saronno 10
Shanghai 10
Spoleto 10
West Jordan 10
Florence 8
Hanover 8
Simi Valley 8
Cairo 7
Houston 7
Milan 7
Assisi 6
Falkenstein 6
Fremont 6
Kraków 6
Ness Ziona 6
Renton 6
San Diego 6
Tokyo 6
Abidjan 5
Bologna 5
Guangzhou 5
Lappeenranta 5
Misano Adriatico 5
Philadelphia 5
Saint Louis 5
Tappahannock 5
Lausanne 4
Macerata 4
Montefalco 4
Nanjing 4
Ottawa 4
San Giustino 4
Seoul 4
Terni 4
Winston-Salem 4
Cassino 3
Esslingen am Neckar 3
Ludwigshafen 3
Nagold 3
Palermo 3
Rieti 3
Timisoara 3
Torino 3
Vienna 3
Wear 3
Amelia 2
Auckland 2
Bodø 2
Bratislava 2
Edinburgh 2
Groningen 2
Hangzhou 2
Irapuato 2
Kiev 2
Monreale 2
Monza 2
Nanning 2
Naples 2
Nea Smyrni 2
Totale 6.740
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Nome #
1,4 Benzothiazine and 1,4 benzoxazine imidazole derivatives with antifungal activity: a docking study 222
Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1. 123
Aryl hydrocarbon receptor control of a disease tolerance defence pathway. 115
A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells 113
Computational studies in enantioselective liquid chromatography: Forty years of evolution in docking- and molecular dynamics-based simulations 111
Class IA PI3Ks regulate subcellular and functional dynamics of IDO1 111
Identification of a 2-propanol analogue modulating the non-enzymatic function of indoleamine 2,3-dioxygenase 1 98
Insights into the molecular function of the inactivating mutations of B-Raf involving the DFG motif 96
Binding Mode and Structure-Activity Relationships of ITE as an Aryl Hydrocarbon Receptor (AhR) Agonist 93
Genotyping of an Italian papillary thyroid carcinoma cohort revealed high prevalence of BRAF mutations, absence of RAS mutations and allowed the detection of a new mutation of BRAF oncoprotein (BRAF). 90
Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry 90
Avicholic Acid: A Primary Bile Acid from Birds on the Route to Potent and Selective TGR5 Ligands 87
Fragment-based approach to identify IDO1 inhibitor building blocks 84
Structure of Metal-Carbenoid Intermediates Derived from the Dirhodium(II)Tetracarboxylate Mediated Decomposition of ?-Diazocarbonyl Compounds. An ab initio and DTF Study 78
Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1 78
Towards New Neuroprotective Agents: Design and Synthesis of Thieno[2,3-c]-isoquinolinon-5-one as a Potent PARP-1 Inhibitor. 77
Glucocorticoid-induced leucine zipper (GILZ)/NF-kB interaction: role of GILZ homo-dimerization and C-terminal domain 76
Spiro[2.2]pentane as a Dissymmetric Scaffold for Conformationally Constrained Analogues of Glutamic Acid: Focus on Racemic 1-Aminospiro[2.2]pentyl-1,4-dicarboxylic Acids 74
87P - Towards the identification of the mechanism of action of antitumor 1-methyl-D-tryptophan 74
Analisi del meccanismo dominante inibitorio esercitato in cis dalle mutazioni inattivanti D594V e G596R sulla mutazione attivante di BRAF V600E 71
Design, Synthesis and Preliminay Evaluation of Novel 3’-Substituted Carboxycyclopropylglycines as Antagonists at Group 2 Metabotropic Glutamate Receptors 71
Metabotropic glutamate receptors: structure and new subtype-selective ligands 70
Evaluation of the enantiomeric selectivity in the Chiral Ligand-Exchange Chromatography of amino acids by a computational model 70
Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5. 70
Spiro[2.2]pentane as a dyssymetric scaffold for conformationally constrained analogues of glutamic acid: diastereodivergent synthesis of 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids 70
D-leucine microparticles as an excipient to improve the aerosolization performances of dry powders for inhalation 70
Insights into Phenylalanine Derivatives Recognition of VLA-4 Integrin: from a Pharmacophoric Study to 3D-QSAR and Molecular Docking Analyses 69
Design and synthesis of 4H-thieno[2,3-c]isoquinolin-5-one derivatives as potent PARP-1 inhibitors, on route of new antiischemic agents 69
Preclinical discovery and development of fingolimod for the treatment of multiple sclerosis 69
Caratterizzazione biochimica e molecolare della nuova mutazione BRAFV599Ins recentemente individuata in un carcinoma papillare della tiroide 68
Oxime and Oxime Ether Derivatives of 1,4-Benzothiazine Related to Oxiconazole. 68
Adamantyl-substituted retinoid-derived molecules that intercact with the orphan nuclear receptor small heterodimer partner:effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity 67
Protective effects of Commiphora erythraea resin constituents against cellular oxidative damage 67
Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure-Activity Relationships and Molecular Modeling Studies 65
Insights into the molecular function of the inactivating mutations of B-Raf involving the DFG motif. 65
Sequence variants in kynurenine aminotransferase II (KAT II) orthologs determine different potencies of the inhibitor S-ESBA 65
PARP inhibitors: polypharmacology versus selective inhibition 64
Alternative strategies for targeting mouse double minute 2 activity with small molecules: novel patents on the horizon? 63
Binding Mode of 6ECDCA, a Potent Bile Acid Agonist of the Farnesoid X Receptor (FXR) 62
Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs. 61
Discovery of 6α-Ethyl-23(S)-methyl-cholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity 61
Side chain modified HDCA derivatives: synthesis, CMC determination and molecular modelling studies. 61
AhR-Mediated, Non-Genomic Modulation of IDO1 Function 61
S-Trityl-(R)-cysteine, a powerful chiral selector for the analytical and preparative ligand-exchange chromatography of amino acids 60
Molecular dynamic simulations of the catalytic domain of BRAF in response to activating and inactivating mutations 60
Rat Brain Guanosine Binding Site:Biological Studies and Pseudo Receptor Construction 60
Metabotropic Glutamate Receptors: A Structural View Point 60
Homology Modeling of AMPA Receptors: Route to the identification of noncompetitive antagonists binding site 60
Synthesis, Molecular modeling studies and preliminary pharmacological characterization of all the eight possible 2-(2'sulfonocylcopropyl)glycine stereoisomers, as conformationally constrined L-homocysteic acid analogs 60
Design, Synthesis, and Microbiolgical Evaluation of New Candida albicans CYP51 Inhibitors 60
Avicholic acid: a lead compound from birds on the route to potent TGR5 modulators 59
Targeting the FXR nuclear receptor through a virtual screening approach 59
Ligand Binding and Functional Selectivity ofl-Tryptophan Metabolites at the Mouse Aryl Hydrocarbon Receptor (mAhR) 59
Tracking Hidden Binding Pockets Along the Molecular Recognition Path of l-Trp to Indoleamine 2,3-Dioxygenase 1 59
Targeting the FXR Nuclear Receptor through a Virtual Screening Approach 58
Le sostituzioni aminoacidiche G596R e D594V hanno un effetto inibitorio dominante sulla funzione della mutazione V600E di BRAF 57
Integrated Fragment-Based Approaches on the Route to Novel IDO1 Modulators 57
Novel ketoconazole analogues based on the replacement of 2,4-dichlorophenyl group with 1,4-benzothiazine moiety: design, synthesis, and microbiological evaluation 56
1μs Molecular Dynamics Simulations to study the poisoning effect of the PARP-1 full length enzyme 56
9. The Systems Biology of Transporters – Targeting the Regulatory System for Transporters (FXR/RXR) 56
Binding modes of noncompetitive AMPA Antagonists: A computational approach 55
Bulky 1,4-benzoxazine derivatives with antifungal activity 55
Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ 55
A novel mutation of indoleamine 2,3-dioxygenase 1 causes a rapid proteasomal degradation and compromises protein function 55
A new computational model to predict the elution order in the chiral ligand-exchange chromatography (CLEC) of amino acids 54
Targeting the MDM2/MDM4 Interaction Interface as a Promising Approach for p53 Reactivation Therapy 53
Binding properties of different categories of IDO1 inhibitors: A microscale thermophoresis study 53
The effect of the copper(II) salt anion in the Chiral Ligand-Exchange Chromatography of amino acids 53
Modeling of Poly(ADP-ribose)polymerase (PARP) Inhibitors. Docking of Ligands and QSAR 52
Derived chromatographic indices as effective tools to study the self-aggregation process of bile acids 52
Chromatographic hydrophobicity index: a high-throughput tool to estimate the critical micellar concentration of bile acids 52
Integrating Multicomponent Flow Synthesis and Computational Approaches for the Generation of a Tetrahydroquinoline Compound Based Library 52
Beyond Bile Acids: Targeting Farnesoid X Receptor (FXR) with Natural and Synthetic Ligands 52
(S)-(-)-alpha,alpha-Di(2-naphthyl)-2-pyrrolidine Methanol, a Useful Tool to Study the Recognition Mechanism in Chiral Ligand-Exchange Chromatography (CLEC) 51
Expanding the horizon of chemotherapeutic targets: From MDM2 to MDMX (MDM4). 51
Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy. 51
Molecular dynamics simulation of the ligand binding domain of mGluR1 in response to agonist and antagonist binding. 50
Unravelling the molecular basis for DAF-12 activation: diastereoselective synthesis and SAR studies of dafachronic acid derivatives. 50
Quantum mechanics/molecular mechanics (QM/MM) modeling of the irreversible transamination of L-kynurenine to kynurenic acid: The round dance of kynurenine aminotransferase II 49
Bile Acid Derivatives as Ligands of the Farnesoid X Receptor: Molecular Determinants for Bile Acid Binding and Receptor Modulation 49
Cyclopropyl Dafachronic Acid Stereoisomers as Conformationally Constrained DAF-12 Ligands 49
Unveiling hidden features of orphan nuclear receptors: The case of the small heterodimer partner (SHP). 48
(S)-(-)-a,a-Di(2-naphthyl)-2-pyrrolidine Methanol, a useful tool to study the recognition mechanism in chiral ligand-exchange chromatography (CLEC) 48
Identification by virtual screening and in vitro testing of human DOPA decarboxylase inhibitors. 48
New Insights from Crystallographic Data: Diversity of Structural Motifs and Molecular Recognition Properties between Groups of IDO1 Structures 48
Molecular docking and spatial coarse graining simulations as tools to investigate substrate recognition, enhancer binding and conformational transitions in indoleamine-2,3-dioxygenase (IDO). 47
INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IS UPREGULATED IN THYROID CARCINOMA AND DRIVES THE DEVELOPMENT OF AN IMMUNOSUPPRESSANT TUMOR MICROENVIRONMENT. 47
Exploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists 47
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine 47
Synthesis, docking studies and anti-inflammatory activity of 4,5,6,7-tetrahydro-2H-indazole derivatives 46
Highlights at the gate of tryptophan catabolism: a review on the mechanism of activation and regulation of indoleamine 2,3-dioxigenase (IDO), a novel target in cancer disease 46
Targeting the conformational transitions of MDM2 and MDMX: insights into dissimilarities and similarities of p53 recognition. 46
QSAR study of anticonvulsant negative allosteric modulators of the AMPA receptor. 46
Novel body modified bile acid derivatives as TGR5 modulators 46
Elucidation of the chromatographic enantiomer elution order through computational studies 46
Chiral ligand-exchange separation and resolution of extremely rigid glutamate analogues: 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids 45
Divergent and stereoselective synthesis of dafachronic acids 45
The Janus-faced nature of IDO1 in infectious diseases: Challenges and therapeutic opportunities 45
4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP) 45
VERY LONG CHAIN FATTY ACID SPHINGOMYELIN IN NUCLEAR LIPID MICRODOMAINS OF HEPATOCYTES AND HEPATOMA CELLS: CAN THE EXCHANGE FROM C24:0 TO C16:0 AFFECT SIGNAL PROTEINS AND VITAMIN D RECEPTOR? 45
Totale 6.457
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Categoria #
all - tutte 40.479
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 40.479
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/201997 0 0 0 0 0 0 0 0 0 0 76 21
2019/2020991 28 17 131 13 151 26 159 35 175 143 27 86
2020/20212.098 13 149 79 141 622 134 164 36 265 81 157 257
2021/20222.140 49 326 39 132 59 34 18 638 113 142 238 352
2022/20233.543 256 630 43 272 329 374 7 147 1.288 27 131 39
2023/20241.090 129 200 74 22 13 20 283 51 201 51 46 0
Totale 11.200