IRIS - Res&Arch Institutional Research Information System - Research & Archive

MACCHIARULO, Antonio
 Distribuzione geografica
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Continente #
NA - Nord America 7.179
EU - Europa 6.014
AS - Asia 4.648
SA - Sud America 832
AF - Africa 94
Continente sconosciuto - Info sul continente non disponibili 11
OC - Oceania 6
Totale 18.784
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Nazione #
US - Stati Uniti d'America 7.042
SG - Singapore 2.121
IT - Italia 1.194
IE - Irlanda 1.002
UA - Ucraina 916
HK - Hong Kong 779
BR - Brasile 706
CN - Cina 706
SE - Svezia 678
RU - Federazione Russa 617
DE - Germania 472
VN - Vietnam 422
FI - Finlandia 298
KR - Corea 242
GB - Regno Unito 190
FR - Francia 145
RO - Romania 105
TR - Turchia 88
CA - Canada 67
BE - Belgio 59
AR - Argentina 58
NL - Olanda 56
IN - India 54
PL - Polonia 52
CZ - Repubblica Ceca 47
MX - Messico 47
JP - Giappone 42
AT - Austria 37
CH - Svizzera 36
UZ - Uzbekistan 32
BD - Bangladesh 30
ZA - Sudafrica 29
ES - Italia 26
EC - Ecuador 22
GR - Grecia 22
LT - Lituania 16
ID - Indonesia 15
CO - Colombia 13
IQ - Iraq 12
LB - Libano 12
MA - Marocco 12
EG - Egitto 11
AE - Emirati Arabi Uniti 10
EU - Europa 10
PK - Pakistan 9
TN - Tunisia 9
BG - Bulgaria 8
IL - Israele 8
JO - Giordania 8
MD - Moldavia 8
VE - Venezuela 8
PE - Perù 7
PY - Paraguay 7
CI - Costa d'Avorio 6
SA - Arabia Saudita 6
CL - Cile 5
DZ - Algeria 5
NO - Norvegia 5
AM - Armenia 4
DK - Danimarca 4
IR - Iran 4
NP - Nepal 4
PH - Filippine 4
PT - Portogallo 4
SK - Slovacchia (Repubblica Slovacca) 4
CR - Costa Rica 3
KE - Kenya 3
LA - Repubblica Popolare Democratica del Laos 3
MY - Malesia 3
NI - Nicaragua 3
NZ - Nuova Zelanda 3
OM - Oman 3
PR - Porto Rico 3
PS - Palestinian Territory 3
SN - Senegal 3
TH - Thailandia 3
TT - Trinidad e Tobago 3
UY - Uruguay 3
AF - Afghanistan, Repubblica islamica di 2
AU - Australia 2
AZ - Azerbaigian 2
BB - Barbados 2
BW - Botswana 2
CG - Congo 2
DO - Repubblica Dominicana 2
EE - Estonia 2
GE - Georgia 2
JM - Giamaica 2
KW - Kuwait 2
KZ - Kazakistan 2
LV - Lettonia 2
NG - Nigeria 2
RS - Serbia 2
SY - Repubblica araba siriana 2
TW - Taiwan 2
AO - Angola 1
BA - Bosnia-Erzegovina 1
BH - Bahrain 1
BN - Brunei Darussalam 1
BO - Bolivia 1
Totale 18.755
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Città #
Singapore 1.336
Chandler 1.079
Dublin 1.000
Hong Kong 772
Perugia 544
San Mateo 506
Jacksonville 494
Boardman 374
Ashburn 340
Santa Clara 320
Medford 238
Princeton 235
Altamura 225
Moscow 222
Seoul 222
Dong Ket 217
Wilmington 201
Beijing 171
Lawrence 165
Munich 165
Ann Arbor 154
Andover 148
Redmond 131
Los Angeles 124
New York 99
Bucharest 92
Piscataway 79
Des Moines 74
Ho Chi Minh City 73
São Paulo 67
Izmir 63
Saint Petersburg 60
Brussels 57
Woodbridge 52
The Dalles 51
Turku 51
Hanoi 41
Norwalk 41
Dallas 39
Helsinki 37
Rome 37
Tokyo 36
Falls Church 35
San Paolo di Civitate 34
Warsaw 31
Chicago 30
Nuremberg 29
Orem 27
Auburn Hills 26
Pisa 26
Shanghai 26
Chennai 25
Montreal 25
Redwood City 25
Stockholm 24
Denver 23
Brooklyn 22
Johannesburg 22
Olomouc 22
Phoenix 22
Columbus 21
London 21
San Francisco 21
Atlanta 19
Belo Horizonte 19
Brno 19
Hefei 18
Boston 17
Mexico City 17
Poplar 17
Rio de Janeiro 16
Den Haag 15
Ankara 14
Dearborn 14
Houston 14
Manchester 14
Amsterdam 13
Guangzhou 13
Seattle 13
Tashkent 13
West Jordan 13
Brasília 12
Campinas 12
Florence 12
Vienna 12
Bologna 11
Cairo 11
Falkenstein 11
Frankfurt Am Main 11
Frankfurt am Main 11
Haiphong 11
Mcallen 11
Ottawa 11
Toronto 11
Saronno 10
Secaucus 10
Spoleto 10
Tianjin 10
Charlotte 9
Chiajna 9
Totale 11.452
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Nome #
1,4 Benzothiazine and 1,4 benzoxazine imidazole derivatives with antifungal activity: a docking study 299
Class IA PI3Ks regulate subcellular and functional dynamics of IDO1 187
Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1. 164
A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells 158
Aryl hydrocarbon receptor control of a disease tolerance defence pathway. 155
Identification of a 2-propanol analogue modulating the non-enzymatic function of indoleamine 2,3-dioxygenase 1 149
Binding Mode and Structure-Activity Relationships of ITE as an Aryl Hydrocarbon Receptor (AhR) Agonist 146
Computational studies in enantioselective liquid chromatography: Forty years of evolution in docking- and molecular dynamics-based simulations 145
Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry 142
Insights into the molecular function of the inactivating mutations of B-Raf involving the DFG motif 131
Fragment-based approach to identify IDO1 inhibitor building blocks 129
87P - Towards the identification of the mechanism of action of antitumor 1-methyl-D-tryptophan 128
Genotyping of an Italian papillary thyroid carcinoma cohort revealed high prevalence of BRAF mutations, absence of RAS mutations and allowed the detection of a new mutation of BRAF oncoprotein (BRAF). 127
Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation 125
9. The Systems Biology of Transporters – Targeting the Regulatory System for Transporters (FXR/RXR) 119
Glucocorticoid-induced leucine zipper (GILZ)/NF-kB interaction: role of GILZ homo-dimerization and C-terminal domain 117
Avicholic Acid: A Primary Bile Acid from Birds on the Route to Potent and Selective TGR5 Ligands 115
A novel mutation of indoleamine 2,3-dioxygenase 1 causes a rapid proteasomal degradation and compromises protein function 115
Tracking Hidden Binding Pockets Along the Molecular Recognition Path of l-Trp to Indoleamine 2,3-Dioxygenase 1 113
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine 113
Analisi del meccanismo dominante inibitorio esercitato in cis dalle mutazioni inattivanti D594V e G596R sulla mutazione attivante di BRAF V600E 112
Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1 112
Adamantyl-substituted retinoid-derived molecules that intercact with the orphan nuclear receptor small heterodimer partner:effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity 110
Oxime and Oxime Ether Derivatives of 1,4-Benzothiazine Related to Oxiconazole. 110
Binding properties of different categories of IDO1 inhibitors: A microscale thermophoresis study 109
Structure of Metal-Carbenoid Intermediates Derived from the Dirhodium(II)Tetracarboxylate Mediated Decomposition of ?-Diazocarbonyl Compounds. An ab initio and DTF Study 106
D-leucine microparticles as an excipient to improve the aerosolization performances of dry powders for inhalation 105
Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5. 104
Towards New Neuroprotective Agents: Design and Synthesis of Thieno[2,3-c]-isoquinolinon-5-one as a Potent PARP-1 Inhibitor. 104
Critical Assessment of a Structure-Based Screening Campaign for IDO1 Inhibitors: Tips and Pitfalls 102
A back-door insight into the modulation of Src kinase activity by the polyamine spermidine 101
(S)-(-)-alpha,alpha-Di(2-naphthyl)-2-pyrrolidine Methanol, a Useful Tool to Study the Recognition Mechanism in Chiral Ligand-Exchange Chromatography (CLEC) 101
Binding Mode of 6ECDCA, a Potent Bile Acid Agonist of the Farnesoid X Receptor (FXR) 101
Preclinical discovery and development of fingolimod for the treatment of multiple sclerosis 101
Spiro[2.2]pentane as a dyssymetric scaffold for conformationally constrained analogues of glutamic acid: diastereodivergent synthesis of 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids 100
Cyclopropyl Dafachronic Acid Stereoisomers as Conformationally Constrained DAF-12 Ligands 100
Design, Synthesis and Preliminay Evaluation of Novel 3’-Substituted Carboxycyclopropylglycines as Antagonists at Group 2 Metabotropic Glutamate Receptors 99
Spiro[2.2]pentane as a Dissymmetric Scaffold for Conformationally Constrained Analogues of Glutamic Acid: Focus on Racemic 1-Aminospiro[2.2]pentyl-1,4-dicarboxylic Acids 99
Integrated Fragment-Based Approaches on the Route to Novel IDO1 Modulators 99
Bulky 1,4-benzoxazine derivatives with antifungal activity 97
A new computational model to predict the elution order in the chiral ligand-exchange chromatography (CLEC) of amino acids 97
AhR-Mediated, Non-Genomic Modulation of IDO1 Function 97
New Insights from Crystallographic Data: Diversity of Structural Motifs and Molecular Recognition Properties between Groups of IDO1 Structures 97
Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure-Activity Relationships and Molecular Modeling Studies 96
Caratterizzazione biochimica e molecolare della nuova mutazione BRAFV599Ins recentemente individuata in un carcinoma papillare della tiroide 96
Discovery of 6α-Ethyl-23(S)-methyl-cholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity 95
Beyond Bile Acids: Targeting Farnesoid X Receptor (FXR) with Natural and Synthetic Ligands 95
Enantioselective HPLC analysis to assist the chemical exploration of chiral imidazolines 95
Protective effects of Commiphora erythraea resin constituents against cellular oxidative damage 94
1μs Molecular Dynamics Simulations to study the poisoning effect of the PARP-1 full length enzyme 94
Microscale thermophoresis and docking studies suggest lapachol and auraptene are ligands of IDO1 94
Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs. 93
Metabotropic glutamate receptors: structure and new subtype-selective ligands 93
(S)-(-)-a,a-Di(2-naphthyl)-2-pyrrolidine Methanol, a useful tool to study the recognition mechanism in chiral ligand-exchange chromatography (CLEC) 93
Side chain modified HDCA derivatives: synthesis, CMC determination and molecular modelling studies. 93
Alternative strategies for targeting mouse double minute 2 activity with small molecules: novel patents on the horizon? 92
Insights into the molecular function of the inactivating mutations of B-Raf involving the DFG motif. 91
Insights into Phenylalanine Derivatives Recognition of VLA-4 Integrin: from a Pharmacophoric Study to 3D-QSAR and Molecular Docking Analyses 91
Design, Synthesis, and Microbiolgical Evaluation of New Candida albicans CYP51 Inhibitors 91
Design and synthesis of 4H-thieno[2,3-c]isoquinolin-5-one derivatives as potent PARP-1 inhibitors, on route of new antiischemic agents 91
Targeting the FXR nuclear receptor through a virtual screening approach 90
Evaluation of the enantiomeric selectivity in the Chiral Ligand-Exchange Chromatography of amino acids by a computational model 89
Ligand Binding and Functional Selectivity ofl-Tryptophan Metabolites at the Mouse Aryl Hydrocarbon Receptor (mAhR) 89
Sequence variants in kynurenine aminotransferase II (KAT II) orthologs determine different potencies of the inhibitor S-ESBA 89
Avicholic acid: a lead compound from birds on the route to potent TGR5 modulators 88
PARP inhibitors: polypharmacology versus selective inhibition 88
Estimating the hydrophobicity extent of molecular fragments using reversed‐phase liquid chromatography 87
Molecular dynamic simulations of the catalytic domain of BRAF in response to activating and inactivating mutations 87
Bile Acid Derivatives as Ligands of the Farnesoid X Receptor: Molecular Determinants for Bile Acid Binding and Receptor Modulation 87
The Stone Guest: How Does pH Affect Binding Properties of PD-1/PD-L1 Inhibitors? 87
Fragment based drug design and diversity-oriented synthesis of carboxylic acid isosteres 86
Rat Brain Guanosine Binding Site:Biological Studies and Pseudo Receptor Construction 85
Homology Modeling of AMPA Receptors: Route to the identification of noncompetitive antagonists binding site 85
Chromatographic hydrophobicity index: a high-throughput tool to estimate the critical micellar concentration of bile acids 85
Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy. 85
VERY LONG CHAIN FATTY ACID SPHINGOMYELIN IN NUCLEAR LIPID MICRODOMAINS OF HEPATOCYTES AND HEPATOMA CELLS: CAN THE EXCHANGE FROM C24:0 TO C16:0 AFFECT SIGNAL PROTEINS AND VITAMIN D RECEPTOR? 85
Optimized one-pot derivatization and enantioseparation of cysteine: Application to the study of a dietary supplement 85
Phenolic acids from Lycium barbarum leaves: In vitro and in silico studies of the inhibitory activity against porcine pancreatic α-amylase 85
Natural cellulosic biofunctional textiles from onion (Allium cepa L.) skin extracts: a sustainable strategy for skin protection 84
The signaling function of IDO1 incites the malignant progression of mouse B16 melanoma 83
S-Trityl-(R)-cysteine, a powerful chiral selector for the analytical and preparative ligand-exchange chromatography of amino acids 83
Synthesis, Molecular modeling studies and preliminary pharmacological characterization of all the eight possible 2-(2'sulfonocylcopropyl)glycine stereoisomers, as conformationally constrined L-homocysteic acid analogs 83
Targeting Aryl hydrocarbon receptor for next-generation immunotherapies: Selective modulators (SAhRMs) versus rapidly metabolized ligands (RMAhRLs) 83
Metabotropic Glutamate Receptors: A Structural View Point 82
Binding modes of noncompetitive AMPA Antagonists: A computational approach 82
Unravelling the molecular basis for DAF-12 activation: diastereoselective synthesis and SAR studies of dafachronic acid derivatives. 82
Elucidation of the chromatographic enantiomer elution order through computational studies 81
Lead optimization-hit expansion of new asymmetrical pyridinium/quinolinium compounds as choline kinase α1 inhibitors 81
Exploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists 81
One Key and Multiple Locks: Substrate Binding in Structures of Tryptophan Dioxygenases and Hydroxylases 81
Le sostituzioni aminoacidiche G596R e D594V hanno un effetto inibitorio dominante sulla funzione della mutazione V600E di BRAF 80
Novel ketoconazole analogues based on the replacement of 2,4-dichlorophenyl group with 1,4-benzothiazine moiety: design, synthesis, and microbiological evaluation 80
Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy 80
Taxifolin and gastro-adhesive microparticles containing taxifolin promotes gastric healing in vivo, inhibits Helicobacter pylori in vitro and proton pump reversibly in silico 80
Glucocorticoid Induced Leucine Zipper (GILZ) inhibits the RAF-ERK pathway by binding to RAF-1 80
INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IS UPREGULATED IN THYROID CARCINOMA AND DRIVES THE DEVELOPMENT OF AN IMMUNOSUPPRESSANT TUMOR MICROENVIRONMENT. 79
Integrating Multicomponent Flow Synthesis and Computational Approaches for the Generation of a Tetrahydroquinoline Compound Based Library 79
Chiral ligand-exchange separation and resolution ofextremely rigid glutamate analogs: 1-aminospiro[2.2]pentyl-1,4-dicarboxylicacids. 78
Bile acids: property-activity relationship and molecular modelling studies 78
Targeting the MDM2/MDM4 Interaction Interface as a Promising Approach for p53 Reactivation Therapy 78
Totale 10.167
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Categoria #
all - tutte 88.517
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 88.517
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.094 0 0 0 0 0 134 164 36 265 81 157 257
2021/20222.140 49 326 39 132 59 34 18 638 113 142 238 352
2022/20233.543 256 630 43 272 329 374 7 147 1.288 27 131 39
2023/20241.595 129 200 74 22 13 20 283 51 201 51 233 318
2024/20253.920 59 336 195 165 435 221 233 296 756 211 660 353
2025/20263.887 572 648 397 980 1.079 211 0 0 0 0 0 0
Totale 19.512