IRIS - Res&Arch Institutional Research Information System - Research & Archive

MACCHIARULO, Antonio
 Distribuzione geografica
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Continente #
NA - Nord America 8.654
EU - Europa 6.744
AS - Asia 6.385
SA - Sud America 1.056
AF - Africa 186
Continente sconosciuto - Info sul continente non disponibili 11
OC - Oceania 9
Totale 23.045
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Nazione #
US - Stati Uniti d'America 8.463
SG - Singapore 2.989
IT - Italia 1.292
IE - Irlanda 1.002
UA - Ucraina 925
RU - Federazione Russa 851
CN - Cina 844
HK - Hong Kong 830
BR - Brasile 815
SE - Svezia 684
VN - Vietnam 600
DE - Germania 495
FR - Francia 392
FI - Finlandia 311
KR - Corea 242
GB - Regno Unito 227
IN - India 155
BD - Bangladesh 144
TR - Turchia 125
RO - Romania 118
AR - Argentina 95
CA - Canada 84
NL - Olanda 69
PL - Polonia 65
MX - Messico 64
BE - Belgio 59
JP - Giappone 57
IQ - Iraq 54
UZ - Uzbekistan 52
CZ - Repubblica Ceca 49
ZA - Sudafrica 48
CO - Colombia 41
PK - Pakistan 39
AT - Austria 38
CH - Svizzera 36
ID - Indonesia 35
EC - Ecuador 32
ES - Italia 32
PH - Filippine 29
JO - Giordania 27
VE - Venezuela 26
SA - Arabia Saudita 24
GR - Grecia 23
EG - Egitto 19
LT - Lituania 18
TN - Tunisia 18
MA - Marocco 17
ET - Etiopia 15
LB - Libano 15
PE - Perù 14
AE - Emirati Arabi Uniti 13
PY - Paraguay 13
IL - Israele 12
MY - Malesia 12
CL - Cile 11
DZ - Algeria 11
KE - Kenya 11
CR - Costa Rica 10
EU - Europa 10
JM - Giamaica 10
AZ - Azerbaigian 9
BG - Bulgaria 9
NP - Nepal 9
MD - Moldavia 8
CI - Costa d'Avorio 7
OM - Oman 7
AO - Angola 6
KG - Kirghizistan 6
KZ - Kazakistan 6
NO - Norvegia 6
AM - Armenia 5
AU - Australia 5
DK - Danimarca 5
GE - Georgia 5
IR - Iran 5
PT - Portogallo 5
QA - Qatar 5
SN - Senegal 5
KW - Kuwait 4
LY - Libia 4
PS - Palestinian Territory 4
SK - Slovacchia (Repubblica Slovacca) 4
TH - Thailandia 4
UY - Uruguay 4
BF - Burkina Faso 3
DO - Repubblica Dominicana 3
HU - Ungheria 3
LA - Repubblica Popolare Democratica del Laos 3
LV - Lettonia 3
NG - Nigeria 3
NI - Nicaragua 3
NZ - Nuova Zelanda 3
PA - Panama 3
PR - Porto Rico 3
RS - Serbia 3
SR - Suriname 3
SY - Repubblica araba siriana 3
TT - Trinidad e Tobago 3
AF - Afghanistan, Repubblica islamica di 2
AL - Albania 2
Totale 22.994
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Città #
Singapore 2.126
Chandler 1.079
Dublin 1.000
San Jose 836
Hong Kong 821
Perugia 562
Ashburn 512
San Mateo 506
Jacksonville 494
Boardman 374
Santa Clara 356
Moscow 310
Medford 238
Princeton 235
Lauterbourg 231
Altamura 225
Seoul 222
Dong Ket 217
Beijing 203
Wilmington 201
Munich 168
Lawrence 165
Ann Arbor 154
Andover 148
Los Angeles 143
Redmond 131
New York 125
Ho Chi Minh City 122
Bucharest 93
The Dalles 89
Hanoi 82
Piscataway 79
São Paulo 76
Des Moines 75
Izmir 65
Orem 64
Saint Petersburg 60
Brussels 57
Woodbridge 52
Turku 51
Dallas 48
Helsinki 48
Tokyo 48
Chennai 47
Rome 43
Warsaw 43
Norwalk 41
Chicago 38
Falls Church 35
Nuremberg 35
San Paolo di Civitate 34
Tashkent 33
Shanghai 31
Stockholm 30
Denver 29
Johannesburg 29
Montreal 28
Atlanta 26
Auburn Hills 26
Council Bluffs 26
Pisa 26
Brooklyn 25
Phoenix 25
Poplar 25
Redwood City 25
London 24
Manchester 24
Amman 23
San Francisco 23
Baghdad 22
Houston 22
Olomouc 22
Belo Horizonte 21
Columbus 21
Mexico City 21
Rio de Janeiro 21
Amsterdam 20
Haiphong 20
Boston 19
Brno 19
Frankfurt am Main 19
Ankara 18
Hefei 18
Seattle 17
Brasília 16
Da Nang 16
Addis Ababa 15
Den Haag 15
Medellín 15
New Delhi 15
Cairo 14
Campinas 14
Dearborn 14
Guangzhou 14
Lahore 14
Toronto 14
Bologna 13
Florence 13
Milan 13
Ottawa 13
Totale 14.213
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Nome #
1,4 Benzothiazine and 1,4 benzoxazine imidazole derivatives with antifungal activity: a docking study 324
Class IA PI3Ks regulate subcellular and functional dynamics of IDO1 211
A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells 200
Aryl hydrocarbon receptor control of a disease tolerance defence pathway. 190
Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1. 183
Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry 179
Identification of a 2-propanol analogue modulating the non-enzymatic function of indoleamine 2,3-dioxygenase 1 175
Binding Mode and Structure-Activity Relationships of ITE as an Aryl Hydrocarbon Receptor (AhR) Agonist 169
Computational studies in enantioselective liquid chromatography: Forty years of evolution in docking- and molecular dynamics-based simulations 161
87P - Towards the identification of the mechanism of action of antitumor 1-methyl-D-tryptophan 158
Fragment-based approach to identify IDO1 inhibitor building blocks 155
Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation 155
Insights into the molecular function of the inactivating mutations of B-Raf involving the DFG motif 149
A back-door insight into the modulation of Src kinase activity by the polyamine spermidine 148
Genotyping of an Italian papillary thyroid carcinoma cohort revealed high prevalence of BRAF mutations, absence of RAS mutations and allowed the detection of a new mutation of BRAF oncoprotein (BRAF). 147
A novel mutation of indoleamine 2,3-dioxygenase 1 causes a rapid proteasomal degradation and compromises protein function 144
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine 142
9. The Systems Biology of Transporters – Targeting the Regulatory System for Transporters (FXR/RXR) 141
Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5. 139
Glucocorticoid-induced leucine zipper (GILZ)/NF-kB interaction: role of GILZ homo-dimerization and C-terminal domain 135
Avicholic Acid: A Primary Bile Acid from Birds on the Route to Potent and Selective TGR5 Ligands 134
Critical Assessment of a Structure-Based Screening Campaign for IDO1 Inhibitors: Tips and Pitfalls 134
Tracking Hidden Binding Pockets Along the Molecular Recognition Path of l-Trp to Indoleamine 2,3-Dioxygenase 1 132
Adamantyl-substituted retinoid-derived molecules that intercact with the orphan nuclear receptor small heterodimer partner:effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity 131
Integrated Fragment-Based Approaches on the Route to Novel IDO1 Modulators 128
Analisi del meccanismo dominante inibitorio esercitato in cis dalle mutazioni inattivanti D594V e G596R sulla mutazione attivante di BRAF V600E 127
Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1 127
Oxime and Oxime Ether Derivatives of 1,4-Benzothiazine Related to Oxiconazole. 127
(S)-(-)-alpha,alpha-Di(2-naphthyl)-2-pyrrolidine Methanol, a Useful Tool to Study the Recognition Mechanism in Chiral Ligand-Exchange Chromatography (CLEC) 126
D-leucine microparticles as an excipient to improve the aerosolization performances of dry powders for inhalation 125
PROTACs bearing piperazine-containing linkers: what effect on their protonation state? 123
New Insights from Crystallographic Data: Diversity of Structural Motifs and Molecular Recognition Properties between Groups of IDO1 Structures 123
Enantioselective HPLC analysis to assist the chemical exploration of chiral imidazolines 122
Binding Mode of 6ECDCA, a Potent Bile Acid Agonist of the Farnesoid X Receptor (FXR) 121
Alternative strategies for targeting mouse double minute 2 activity with small molecules: novel patents on the horizon? 121
Chiral mobile phase in ligand-exchange chromatography of amino acids: Exploring the copper(II) salt anion effect with a computational approach 121
AhR-Mediated, Non-Genomic Modulation of IDO1 Function 121
Preclinical discovery and development of fingolimod for the treatment of multiple sclerosis 121
(S)-(-)-a,a-Di(2-naphthyl)-2-pyrrolidine Methanol, a useful tool to study the recognition mechanism in chiral ligand-exchange chromatography (CLEC) 119
Side chain modified HDCA derivatives: synthesis, CMC determination and molecular modelling studies. 119
Binding properties of different categories of IDO1 inhibitors: A microscale thermophoresis study 119
Spiro[2.2]pentane as a Dissymmetric Scaffold for Conformationally Constrained Analogues of Glutamic Acid: Focus on Racemic 1-Aminospiro[2.2]pentyl-1,4-dicarboxylic Acids 118
Optimized one-pot derivatization and enantioseparation of cysteine: Application to the study of a dietary supplement 118
Structure of Metal-Carbenoid Intermediates Derived from the Dirhodium(II)Tetracarboxylate Mediated Decomposition of ?-Diazocarbonyl Compounds. An ab initio and DTF Study 117
Towards New Neuroprotective Agents: Design and Synthesis of Thieno[2,3-c]-isoquinolinon-5-one as a Potent PARP-1 Inhibitor. 117
Bulky 1,4-benzoxazine derivatives with antifungal activity 117
A new computational model to predict the elution order in the chiral ligand-exchange chromatography (CLEC) of amino acids 116
1μs Molecular Dynamics Simulations to study the poisoning effect of the PARP-1 full length enzyme 115
Spiro[2.2]pentane as a dyssymetric scaffold for conformationally constrained analogues of glutamic acid: diastereodivergent synthesis of 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids 114
Cyclopropyl Dafachronic Acid Stereoisomers as Conformationally Constrained DAF-12 Ligands 114
Microscale thermophoresis and docking studies suggest lapachol and auraptene are ligands of IDO1 114
Design, synthesis, and biological evaluation of first-in-class indomethacin-based PROTACs degrading SARS-CoV-2 main protease and with broad-spectrum antiviral activity 113
Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure-Activity Relationships and Molecular Modeling Studies 113
Insights into Phenylalanine Derivatives Recognition of VLA-4 Integrin: from a Pharmacophoric Study to 3D-QSAR and Molecular Docking Analyses 113
Targeting Aryl hydrocarbon receptor for next-generation immunotherapies: Selective modulators (SAhRMs) versus rapidly metabolized ligands (RMAhRLs) 113
Design, Synthesis and Preliminay Evaluation of Novel 3’-Substituted Carboxycyclopropylglycines as Antagonists at Group 2 Metabotropic Glutamate Receptors 111
Protective effects of Commiphora erythraea resin constituents against cellular oxidative damage 110
Taxifolin and gastro-adhesive microparticles containing taxifolin promotes gastric healing in vivo, inhibits Helicobacter pylori in vitro and proton pump reversibly in silico 110
Metabotropic glutamate receptors: structure and new subtype-selective ligands 109
Design, Synthesis, and Microbiolgical Evaluation of New Candida albicans CYP51 Inhibitors 109
Targeting the FXR nuclear receptor through a virtual screening approach 109
Epacadostat stabilizes the apo-form of IDO1 and signals a pro-tumorigenic pathway in human ovarian cancer cells 108
Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs. 108
Caratterizzazione biochimica e molecolare della nuova mutazione BRAFV599Ins recentemente individuata in un carcinoma papillare della tiroide 108
Beyond Bile Acids: Targeting Farnesoid X Receptor (FXR) with Natural and Synthetic Ligands 108
Natural cellulosic biofunctional textiles from onion (Allium cepa L.) skin extracts: a sustainable strategy for skin protection 107
The Stone Guest: How Does pH Affect Binding Properties of PD-1/PD-L1 Inhibitors? 107
Phenolic acids from Lycium barbarum leaves: In vitro and in silico studies of the inhibitory activity against porcine pancreatic α-amylase 106
One Key and Multiple Locks: Substrate Binding in Structures of Tryptophan Dioxygenases and Hydroxylases 106
Insights into the molecular function of the inactivating mutations of B-Raf involving the DFG motif. 105
Design and synthesis of 4H-thieno[2,3-c]isoquinolin-5-one derivatives as potent PARP-1 inhibitors, on route of new antiischemic agents 105
Fragment based drug design and diversity-oriented synthesis of carboxylic acid isosteres 105
Molecular dynamic simulations of the catalytic domain of BRAF in response to activating and inactivating mutations 104
Chromatographic hydrophobicity index: a high-throughput tool to estimate the critical micellar concentration of bile acids 104
Bile Acid Derivatives as Ligands of the Farnesoid X Receptor: Molecular Determinants for Bile Acid Binding and Receptor Modulation 104
VERY LONG CHAIN FATTY ACID SPHINGOMYELIN IN NUCLEAR LIPID MICRODOMAINS OF HEPATOCYTES AND HEPATOMA CELLS: CAN THE EXCHANGE FROM C24:0 TO C16:0 AFFECT SIGNAL PROTEINS AND VITAMIN D RECEPTOR? 104
Targeting Wnt-driven cancers: Discovery of novel tankyrase inhibitors 104
Estimating the hydrophobicity extent of molecular fragments using reversed‐phase liquid chromatography 103
Discovery of 6α-Ethyl-23(S)-methyl-cholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity 103
Avicholic acid: a lead compound from birds on the route to potent TGR5 modulators 103
PARP inhibitors: polypharmacology versus selective inhibition 103
Ligand Binding and Functional Selectivity ofl-Tryptophan Metabolites at the Mouse Aryl Hydrocarbon Receptor (mAhR) 102
Elucidation of the chromatographic enantiomer elution order through computational studies 102
Lead optimization-hit expansion of new asymmetrical pyridinium/quinolinium compounds as choline kinase α1 inhibitors 102
Exploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists 102
Turning a Tumor Microenvironment Pitfall into Opportunity: Discovery of Benzamidoxime as PD-L1 Ligand with pH-Dependent Potency 101
Homology Modeling of AMPA Receptors: Route to the identification of noncompetitive antagonists binding site 101
Unravelling the molecular basis for DAF-12 activation: diastereoselective synthesis and SAR studies of dafachronic acid derivatives. 101
Sequence variants in kynurenine aminotransferase II (KAT II) orthologs determine different potencies of the inhibitor S-ESBA 99
Binding modes of noncompetitive AMPA Antagonists: A computational approach 98
INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IS UPREGULATED IN THYROID CARCINOMA AND DRIVES THE DEVELOPMENT OF AN IMMUNOSUPPRESSANT TUMOR MICROENVIRONMENT. 98
The Janus-faced nature of IDO1 in infectious diseases: Challenges and therapeutic opportunities 98
A general partnership between AhR and tryptophan catabolic enzymes and its role in endotoxin tolerance 98
Glucocorticoid Induced Leucine Zipper (GILZ) inhibits the RAF-ERK pathway by binding to RAF-1 98
S-Trityl-(R)-cysteine, a powerful chiral selector for the analytical and preparative ligand-exchange chromatography of amino acids 97
Evaluation of the enantiomeric selectivity in the Chiral Ligand-Exchange Chromatography of amino acids by a computational model 97
Chiral ligand-exchange separation and resolution ofextremely rigid glutamate analogs: 1-aminospiro[2.2]pentyl-1,4-dicarboxylicacids. 97
Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy. 97
The signaling function of IDO1 incites the malignant progression of mouse B16 melanoma 96
Development of 3α, 7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-sulfate sodium salt (INT-767): Process optimization, synthesis and characterization of metabolites 96
Totale 12.281
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Categoria #
all - tutte 101.675
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 101.675
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021257 0 0 0 0 0 0 0 0 0 0 0 257
2021/20222.140 49 326 39 132 59 34 18 638 113 142 238 352
2022/20233.543 256 630 43 272 329 374 7 147 1.288 27 131 39
2023/20241.595 129 200 74 22 13 20 283 51 201 51 233 318
2024/20253.920 59 336 195 165 435 221 233 296 756 211 660 353
2025/20268.154 572 648 397 980 1.079 744 1.386 431 901 667 248 101
Totale 23.779