IRIS - Res&Arch Institutional Research Information System - Research & Archive

MACCHIARULO, Antonio
 Distribuzione geografica
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Continente #
NA - Nord America 5.421
EU - Europa 4.711
AS - Asia 1.637
AF - Africa 13
Continente sconosciuto - Info sul continente non disponibili 10
SA - Sud America 5
OC - Oceania 2
Totale 11.799
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Nazione #
US - Stati Uniti d'America 5.402
IE - Irlanda 1.000
UA - Ucraina 908
IT - Italia 892
SE - Svezia 653
SG - Singapore 589
HK - Hong Kong 430
DE - Germania 280
CN - Cina 229
FI - Finlandia 226
VN - Vietnam 217
RU - Federazione Russa 196
FR - Francia 125
GB - Regno Unito 99
RO - Romania 95
TR - Turchia 64
KR - Corea 61
BE - Belgio 57
CZ - Repubblica Ceca 41
CH - Svizzera 34
NL - Olanda 26
GR - Grecia 21
PL - Polonia 19
AT - Austria 16
UZ - Uzbekistan 16
MX - Messico 14
EU - Europa 10
LB - Libano 10
JP - Giappone 9
BG - Bulgaria 7
EG - Egitto 7
IL - Israele 7
CI - Costa d'Avorio 6
CA - Canada 5
ES - Italia 4
BR - Brasile 3
NO - Norvegia 3
MY - Malesia 2
NZ - Nuova Zelanda 2
PT - Portogallo 2
SK - Slovacchia (Repubblica Slovacca) 2
BD - Bangladesh 1
CL - Cile 1
CO - Colombia 1
HR - Croazia 1
HU - Ungheria 1
IN - India 1
IR - Iran 1
LV - Lettonia 1
MC - Monaco 1
MD - Moldavia 1
Totale 11.799
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Città #
Chandler 1.079
Dublin 998
San Mateo 506
Jacksonville 493
Singapore 454
Hong Kong 426
Boardman 374
Perugia 337
Medford 238
Princeton 235
Altamura 225
Dong Ket 217
Wilmington 201
Lawrence 165
Ann Arbor 154
Andover 148
Redmond 131
Bucharest 92
Beijing 87
Des Moines 74
Izmir 63
Saint Petersburg 60
Brussels 55
Woodbridge 52
Norwalk 41
Seoul 41
Ashburn 39
Falls Church 35
San Paolo di Civitate 34
Los Angeles 32
Santa Clara 32
Auburn Hills 26
Pisa 26
Redwood City 25
Helsinki 24
Moscow 22
New York 22
Munich 21
Brno 19
Dallas 19
Rome 18
Olomouc 17
Shanghai 17
Den Haag 15
Dearborn 14
Chicago 11
Frankfurt Am Main 11
Mcallen 11
Florence 10
Saronno 10
Spoleto 10
West Jordan 10
Hanover 8
Simi Valley 8
Boydton 7
Cairo 7
Guangzhou 7
Houston 7
Milan 7
Abidjan 6
Assisi 6
Falkenstein 6
Fremont 6
Kraków 6
Ness Ziona 6
Renton 6
San Diego 6
Tokyo 6
Bologna 5
Lappeenranta 5
Misano Adriatico 5
Philadelphia 5
Saint Louis 5
Tappahannock 5
Vienna 5
Lausanne 4
Macerata 4
Montefalco 4
Nanjing 4
Ottawa 4
San Giustino 4
Terni 4
Washington 4
Winston-Salem 4
Cassino 3
Esslingen am Neckar 3
Groningen 3
Ludwigshafen 3
Nagold 3
Palermo 3
Rieti 3
Timisoara 3
Torgiano 3
Torino 3
Vicenza 3
Wear 3
Amelia 2
Auckland 2
Bodø 2
Bratislava 2
Totale 7.696
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Nome #
1,4 Benzothiazine and 1,4 benzoxazine imidazole derivatives with antifungal activity: a docking study 240
Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1. 128
Class IA PI3Ks regulate subcellular and functional dynamics of IDO1 124
A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells 122
Aryl hydrocarbon receptor control of a disease tolerance defence pathway. 121
Computational studies in enantioselective liquid chromatography: Forty years of evolution in docking- and molecular dynamics-based simulations 119
Identification of a 2-propanol analogue modulating the non-enzymatic function of indoleamine 2,3-dioxygenase 1 108
Binding Mode and Structure-Activity Relationships of ITE as an Aryl Hydrocarbon Receptor (AhR) Agonist 104
Insights into the molecular function of the inactivating mutations of B-Raf involving the DFG motif 100
Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry 100
Genotyping of an Italian papillary thyroid carcinoma cohort revealed high prevalence of BRAF mutations, absence of RAS mutations and allowed the detection of a new mutation of BRAF oncoprotein (BRAF). 98
Avicholic Acid: A Primary Bile Acid from Birds on the Route to Potent and Selective TGR5 Ligands 91
Fragment-based approach to identify IDO1 inhibitor building blocks 91
87P - Towards the identification of the mechanism of action of antitumor 1-methyl-D-tryptophan 85
Structure of Metal-Carbenoid Intermediates Derived from the Dirhodium(II)Tetracarboxylate Mediated Decomposition of ?-Diazocarbonyl Compounds. An ab initio and DTF Study 83
Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1 83
Glucocorticoid-induced leucine zipper (GILZ)/NF-kB interaction: role of GILZ homo-dimerization and C-terminal domain 81
Towards New Neuroprotective Agents: Design and Synthesis of Thieno[2,3-c]-isoquinolinon-5-one as a Potent PARP-1 Inhibitor. 80
Analisi del meccanismo dominante inibitorio esercitato in cis dalle mutazioni inattivanti D594V e G596R sulla mutazione attivante di BRAF V600E 78
Spiro[2.2]pentane as a Dissymmetric Scaffold for Conformationally Constrained Analogues of Glutamic Acid: Focus on Racemic 1-Aminospiro[2.2]pentyl-1,4-dicarboxylic Acids 78
Design, Synthesis and Preliminay Evaluation of Novel 3’-Substituted Carboxycyclopropylglycines as Antagonists at Group 2 Metabotropic Glutamate Receptors 77
Evaluation of the enantiomeric selectivity in the Chiral Ligand-Exchange Chromatography of amino acids by a computational model 75
Oxime and Oxime Ether Derivatives of 1,4-Benzothiazine Related to Oxiconazole. 75
Spiro[2.2]pentane as a dyssymetric scaffold for conformationally constrained analogues of glutamic acid: diastereodivergent synthesis of 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids 75
Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5. 74
Adamantyl-substituted retinoid-derived molecules that intercact with the orphan nuclear receptor small heterodimer partner:effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity 74
Design and synthesis of 4H-thieno[2,3-c]isoquinolin-5-one derivatives as potent PARP-1 inhibitors, on route of new antiischemic agents 74
Metabotropic glutamate receptors: structure and new subtype-selective ligands 73
Caratterizzazione biochimica e molecolare della nuova mutazione BRAFV599Ins recentemente individuata in un carcinoma papillare della tiroide 73
D-leucine microparticles as an excipient to improve the aerosolization performances of dry powders for inhalation 73
Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure-Activity Relationships and Molecular Modeling Studies 71
Insights into Phenylalanine Derivatives Recognition of VLA-4 Integrin: from a Pharmacophoric Study to 3D-QSAR and Molecular Docking Analyses 71
Protective effects of Commiphora erythraea resin constituents against cellular oxidative damage 71
Preclinical discovery and development of fingolimod for the treatment of multiple sclerosis 71
Tracking Hidden Binding Pockets Along the Molecular Recognition Path of l-Trp to Indoleamine 2,3-Dioxygenase 1 70
Discovery of 6α-Ethyl-23(S)-methyl-cholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity 69
Insights into the molecular function of the inactivating mutations of B-Raf involving the DFG motif. 69
Alternative strategies for targeting mouse double minute 2 activity with small molecules: novel patents on the horizon? 69
PARP inhibitors: polypharmacology versus selective inhibition 68
AhR-Mediated, Non-Genomic Modulation of IDO1 Function 68
Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs. 67
Binding Mode of 6ECDCA, a Potent Bile Acid Agonist of the Farnesoid X Receptor (FXR) 67
Side chain modified HDCA derivatives: synthesis, CMC determination and molecular modelling studies. 67
Sequence variants in kynurenine aminotransferase II (KAT II) orthologs determine different potencies of the inhibitor S-ESBA 67
Molecular dynamic simulations of the catalytic domain of BRAF in response to activating and inactivating mutations 65
Integrated Fragment-Based Approaches on the Route to Novel IDO1 Modulators 65
Rat Brain Guanosine Binding Site:Biological Studies and Pseudo Receptor Construction 64
Homology Modeling of AMPA Receptors: Route to the identification of noncompetitive antagonists binding site 64
Synthesis, Molecular modeling studies and preliminary pharmacological characterization of all the eight possible 2-(2'sulfonocylcopropyl)glycine stereoisomers, as conformationally constrined L-homocysteic acid analogs 64
Design, Synthesis, and Microbiolgical Evaluation of New Candida albicans CYP51 Inhibitors 64
Ligand Binding and Functional Selectivity ofl-Tryptophan Metabolites at the Mouse Aryl Hydrocarbon Receptor (mAhR) 64
9. The Systems Biology of Transporters – Targeting the Regulatory System for Transporters (FXR/RXR) 64
A novel mutation of indoleamine 2,3-dioxygenase 1 causes a rapid proteasomal degradation and compromises protein function 64
S-Trityl-(R)-cysteine, a powerful chiral selector for the analytical and preparative ligand-exchange chromatography of amino acids 63
Avicholic acid: a lead compound from birds on the route to potent TGR5 modulators 63
Targeting the FXR nuclear receptor through a virtual screening approach 63
1μs Molecular Dynamics Simulations to study the poisoning effect of the PARP-1 full length enzyme 63
Binding properties of different categories of IDO1 inhibitors: A microscale thermophoresis study 63
Le sostituzioni aminoacidiche G596R e D594V hanno un effetto inibitorio dominante sulla funzione della mutazione V600E di BRAF 62
Metabotropic Glutamate Receptors: A Structural View Point 62
Bulky 1,4-benzoxazine derivatives with antifungal activity 61
Novel ketoconazole analogues based on the replacement of 2,4-dichlorophenyl group with 1,4-benzothiazine moiety: design, synthesis, and microbiological evaluation 61
Targeting the FXR Nuclear Receptor through a Virtual Screening Approach 61
(S)-(-)-alpha,alpha-Di(2-naphthyl)-2-pyrrolidine Methanol, a Useful Tool to Study the Recognition Mechanism in Chiral Ligand-Exchange Chromatography (CLEC) 60
A new computational model to predict the elution order in the chiral ligand-exchange chromatography (CLEC) of amino acids 60
Targeting the MDM2/MDM4 Interaction Interface as a Promising Approach for p53 Reactivation Therapy 60
Binding modes of noncompetitive AMPA Antagonists: A computational approach 59
Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ 59
(S)-(-)-a,a-Di(2-naphthyl)-2-pyrrolidine Methanol, a useful tool to study the recognition mechanism in chiral ligand-exchange chromatography (CLEC) 58
Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy. 57
INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IS UPREGULATED IN THYROID CARCINOMA AND DRIVES THE DEVELOPMENT OF AN IMMUNOSUPPRESSANT TUMOR MICROENVIRONMENT. 57
Cyclopropyl Dafachronic Acid Stereoisomers as Conformationally Constrained DAF-12 Ligands 57
New Insights from Crystallographic Data: Diversity of Structural Motifs and Molecular Recognition Properties between Groups of IDO1 Structures 57
The effect of the copper(II) salt anion in the Chiral Ligand-Exchange Chromatography of amino acids 56
Derived chromatographic indices as effective tools to study the self-aggregation process of bile acids 55
Expanding the horizon of chemotherapeutic targets: From MDM2 to MDMX (MDM4). 55
Chromatographic hydrophobicity index: a high-throughput tool to estimate the critical micellar concentration of bile acids 55
Bile Acid Derivatives as Ligands of the Farnesoid X Receptor: Molecular Determinants for Bile Acid Binding and Receptor Modulation 55
Elucidation of the chromatographic enantiomer elution order through computational studies 55
Beyond Bile Acids: Targeting Farnesoid X Receptor (FXR) with Natural and Synthetic Ligands 55
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine 55
Modeling of Poly(ADP-ribose)polymerase (PARP) Inhibitors. Docking of Ligands and QSAR 54
Molecular dynamics simulation of the ligand binding domain of mGluR1 in response to agonist and antagonist binding. 54
Unravelling the molecular basis for DAF-12 activation: diastereoselective synthesis and SAR studies of dafachronic acid derivatives. 54
Discovery of 3α,7α,11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid (TC-100), a Novel Bile Acid as Potent and Highly Selective FXR Agonist for Enterohepatic Disorders 54
Integrating Multicomponent Flow Synthesis and Computational Approaches for the Generation of a Tetrahydroquinoline Compound Based Library 54
The Janus-faced nature of IDO1 in infectious diseases: Challenges and therapeutic opportunities 53
VERY LONG CHAIN FATTY ACID SPHINGOMYELIN IN NUCLEAR LIPID MICRODOMAINS OF HEPATOCYTES AND HEPATOMA CELLS: CAN THE EXCHANGE FROM C24:0 TO C16:0 AFFECT SIGNAL PROTEINS AND VITAMIN D RECEPTOR? 53
Unveiling hidden features of orphan nuclear receptors: The case of the small heterodimer partner (SHP). 52
Quantum mechanics/molecular mechanics (QM/MM) modeling of the irreversible transamination of L-kynurenine to kynurenic acid: The round dance of kynurenine aminotransferase II 52
A general partnership between AhR and tryptophan catabolic enzymes and its role in endotoxin tolerance 52
Exploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists 52
Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation 52
Microscale thermophoresis and docking studies suggest lapachol and auraptene are ligands of IDO1 51
Targeting the conformational transitions of MDM2 and MDMX: insights into dissimilarities and similarities of p53 recognition. 50
Molecular docking and spatial coarse graining simulations as tools to investigate substrate recognition, enhancer binding and conformational transitions in indoleamine-2,3-dioxygenase (IDO). 50
Bile acids: property-activity relationship and molecular modelling studies 50
Chiral ligand-exchange separation and resolution of extremely rigid glutamate analogues: 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids 50
4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP) 50
Synthesis, docking studies and anti-inflammatory activity of 4,5,6,7-tetrahydro-2H-indazole derivatives 49
Totale 7.033
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Categoria #
all - tutte 52.797
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 52.797
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020802 0 0 0 0 151 26 159 35 175 143 27 86
2020/20212.098 13 149 79 141 622 134 164 36 265 81 157 257
2021/20222.140 49 326 39 132 59 34 18 638 113 142 238 352
2022/20233.543 256 630 43 272 329 374 7 147 1.288 27 131 39
2023/20241.595 129 200 74 22 13 20 283 51 201 51 233 318
2024/2025784 59 336 195 165 29 0 0 0 0 0 0 0
Totale 12.489