IRIS - Res&Arch Institutional Research Information System - Research & Archive

MANFRONI, GIUSEPPE
 Distribuzione geografica
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Continente #
AS - Asia 5.377
NA - Nord America 4.286
EU - Europa 2.987
SA - Sud America 406
AF - Africa 85
OC - Oceania 10
Continente sconosciuto - Info sul continente non disponibili 4
Totale 13.155
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Nazione #
US - Stati Uniti d'America 4.215
CN - Cina 2.504
SG - Singapore 1.542
IT - Italia 721
IE - Irlanda 445
HK - Hong Kong 432
VN - Vietnam 422
RU - Federazione Russa 414
BR - Brasile 311
SE - Svezia 294
UA - Ucraina 276
DE - Germania 182
FR - Francia 147
FI - Finlandia 136
GB - Regno Unito 109
KR - Corea 83
IN - India 70
BE - Belgio 64
TR - Turchia 47
BD - Bangladesh 44
JP - Giappone 40
PL - Polonia 38
IQ - Iraq 35
CA - Canada 34
ES - Italia 30
MX - Messico 30
AR - Argentina 29
NL - Olanda 26
PK - Pakistan 24
ZA - Sudafrica 23
ID - Indonesia 20
UZ - Uzbekistan 18
AT - Austria 17
CH - Svizzera 17
PH - Filippine 17
RO - Romania 17
SA - Arabia Saudita 17
EC - Ecuador 16
CZ - Repubblica Ceca 13
CO - Colombia 12
EG - Egitto 12
MA - Marocco 11
VE - Venezuela 10
CL - Cile 9
AU - Australia 8
LB - Libano 8
AL - Albania 7
ET - Etiopia 7
UY - Uruguay 7
CI - Costa d'Avorio 6
IR - Iran 6
KE - Kenya 6
TN - Tunisia 6
JO - Giordania 5
LT - Lituania 5
LV - Lettonia 5
PE - Perù 5
AZ - Azerbaigian 4
BG - Bulgaria 4
BO - Bolivia 4
DZ - Algeria 4
MY - Malesia 4
NP - Nepal 4
OM - Oman 4
AE - Emirati Arabi Uniti 3
AO - Angola 3
DK - Danimarca 3
EU - Europa 3
HR - Croazia 3
IL - Israele 3
PA - Panama 3
PS - Palestinian Territory 3
RS - Serbia 3
SY - Repubblica araba siriana 3
TH - Thailandia 3
KZ - Kazakistan 2
LY - Libia 2
NZ - Nuova Zelanda 2
PT - Portogallo 2
PY - Paraguay 2
SK - Slovacchia (Repubblica Slovacca) 2
TW - Taiwan 2
AM - Armenia 1
BY - Bielorussia 1
CM - Camerun 1
CR - Costa Rica 1
CY - Cipro 1
DM - Dominica 1
EE - Estonia 1
GA - Gabon 1
GE - Georgia 1
GR - Grecia 1
HN - Honduras 1
HU - Ungheria 1
JM - Giamaica 1
KG - Kirghizistan 1
KW - Kuwait 1
LK - Sri Lanka 1
MD - Moldavia 1
ME - Montenegro 1
Totale 13.147
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Città #
Guangzhou 2.080
Singapore 1.163
Chandler 600
Dublin 445
San Jose 426
Hong Kong 422
Perugia 413
Ashburn 278
Dong Ket 246
San Mateo 226
Boardman 164
Santa Clara 150
Jacksonville 137
Moscow 123
Medford 103
Princeton 103
Beijing 102
Lauterbourg 96
Altamura 95
The Dalles 84
Ann Arbor 83
Los Angeles 83
Seoul 80
Wilmington 80
Ho Chi Minh City 66
Lawrence 66
Brussels 64
New York 56
Fremont 55
Andover 53
Munich 50
São Paulo 43
Orem 36
Piscataway 34
Hanoi 33
Tokyo 33
Redmond 32
Saint Petersburg 31
Dallas 30
Council Bluffs 29
Turku 29
Warsaw 29
Rome 28
Dearborn 27
Des Moines 25
Spoleto 25
Helsinki 23
Atlanta 22
Redwood City 21
Brooklyn 20
West Jordan 20
Falls Church 19
Norwalk 19
Phoenix 19
Denver 18
Chennai 17
Hefei 16
Montreal 16
Baghdad 15
Chicago 15
Columbus 15
Seattle 15
Johannesburg 14
Nuremberg 13
Poplar 13
Stockholm 12
Dhaka 11
Houston 11
Izmir 11
San Diego 11
San Francisco 11
San Giustino 11
Ankara 10
Porto Alegre 10
Amsterdam 9
Buffalo 9
Lappeenranta 9
London 9
Mumbai 9
Rio de Janeiro 9
San Paolo di Civitate 9
Tashkent 9
Toronto 9
Woodbridge 9
Barnet 8
Boston 8
Brasília 8
Cairo 8
Charlotte 8
Da Nang 8
Haiphong 8
Jakarta 8
Manchester 8
Mexico City 8
Quito 8
Shanghai 8
Vienna 8
Addis Ababa 7
Bucharest 7
Den Haag 7
Totale 9.299
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Nome #
Structural investigation of Small Molecules Targeting Influenza A Virus Polymerase 2.139
1,2,4-triazolo[1,5-α]pyrimidines as a novel class of inhibitors of the HIV-1 reverse transcriptase-αssociated ribonuclease h activity 330
1,4-Benzothiazine ATP-Sensitive Potassium Channel Openers: Modifications at the C-2 and C-6 Positions 317
Sintesi di nuovi inibitori della pompa di efflusso NorA dello S. aureus: dalle 3-fenil-1,4-benzotiazine alle 2-fenilchinossaline 164
Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase 154
Antitubercular polyhalogenated phenothiazines and phenoselenazine with reduced binding to CNS receptors 145
New Insights on KCa3.1 Channel Modulation 142
C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors 140
A Broad Anti-influenza Hybrid Small Molecule that Potently Disrupts the Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Subunits Interaction 137
New anti-ovarian cancer quinolone derivatives acting by modulating microRNA processing machinery 135
Derivati 2-fenilchinolonici come inibitori della pompa di efflusso NorA dello Staphylococcus aureus ciprofloxacin resistente 134
2-phenylquinolones as HIV-1 Tat/TAR interaction inhibitors 132
2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction 132
Allosteric inhibition of the hepatitis C virus NS5B polymerase: in silico strategies for drug discovery and development 131
A Journey around the Medicinal Chemistry of Hepatitis C Virus Inhibitors Targeting NS4B: From Target to Preclinical Drug Candidates 130
From Quinoline to Quinazoline-Based S. aureus NorA Efflux Pump Inhibitors by Coupling a Focused Scaffold Hopping Approach and a Pharmacophore Search 129
A New Promising Class of pyrazolobenzothiazine inhibitors of S. aureus NorA Efflux Pump 128
Syhtesis and Biological Evaluation of 2-Phenylquinolones Targeted at Tat/TAR Recognition 127
Broad-Spectrum Flavivirus Inhibitors: a Medicinal Chemistry Point of View 126
Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation 125
A Comprehensive Structural Overview of p38 Mitogen-Activated Protein Kinase in Complex with ATP-Site and Non-ATP-Site Binders 124
Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase 124
6-Desfluoroquinolones as promising HIV transcription inhibitors 123
A Comprehensive Structural Overview of p38α MAPK in Complex with Type I Inhibitors 123
Structure-activity relationship study on anti-HIV 6-desfluoroquinolones. 122
N-Benzoyl-N-methylsulfonyl anthranilates: unexpected cyclization reaction to 4-alkoxy-2,1-benzothiazines 119
Discovery of Novel Inhibitors of the NorA Multidrug Transporter of Staphylococcus aureus. 118
Computer-Aided Identification of Fragments as CDK9 Inhibitors with Anti-HIV-1 Tat-Mediated Transcription Activity 115
Advantageous Use of Ionic Liquids for the Synthesis of Pharmaceutically Relevant Quinolones 115
From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors 115
Targeting CDKs to inhibit the HIV-1 TAT-mediated transcription 114
Bicyclic octahydrocyclohepta[b]pyrrol-4(1H)one derivatives as novel selective anti-hepatitis C virus agents 113
Design and synthesis of WM5 analogues as HIV-1 TAR RNA binders. 113
Inhibition of Subgenomic Hepatitis C Virus RNA Replication by Acridone Derivatives: Identification of an NS3 Helicase Inhibitor. 112
A new quinolone derivative with ultra-potent anti-HIV activity. 111
Broad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions 111
Accounting for target flexibility and water molecules by docking to ensembles of target structures: The HCV NS5B Palm Site I inhibitors case study. 110
Synthesis and Characterization of 1,2,4-Triazolo[1,5-a]pyrimidine-2-carboxamide-based Compounds Targeting the PA-PB1 Interface of Influenza A Virus Polymerase. 110
A New Derivative with Ultra-Potent Anti-HIV Activity 109
Evolution of HCV NS4B Inhibitors 109
Disegno e Sintesi di Nuovi Inibitori Allosterici della NS5B Polimerasi dell'HCV 108
Co-crystal structure determination and cellular evaluation of 1,4-dihydropyrazolo[4,3-c] [1,2] benzothiazine 5,5-dioxide p38α MAPK inhibitors 107
New Pyrazolobenzothiazine Derivatives As Hepatitis C Virus NS5B Polymerase Palm Site I Inhibitors 107
2-Phenylquinazolinone fragment imparts anti-CDKs and anti-HIV activities 104
CYCLOHEPTATHIOPHENE-3-CARBOXAMIDE DERIVATIVES AS INFLUENZA A VIRUS POLYMERASE INHIBITORS 104
A cellular screening platform, stably expressing DENV2 NS5, defines a novel anti-DENV mechanism of action of Apigenin based on STAT2 activation 103
Investigation on the effect of known potent S. aureus NorA efflux pump inhibitors on the staphylococcal biofilm formation 103
Structural Modifications of the Quinolin-4-yloxy Core to Obtain New Staphylococcus aureus NorA Inhibitors 103
Evolution from a natural flavones nucleus to obtain 2-(4-Propoxyphenyl)quinoline derivatives as potent inhibitors of the S. aureus NorA efflux pump. 101
Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors 101
Computer-Aided Design, Synthesis and Validation of 2-Phenylquinazolinone Fragments as CDK9 Inhibitors with Anti-HIV-1 Tat-Mediated Transcription Activity 100
Searching for Novel Inhibitors of the S. aureus NorA Efflux Pump: Synthesis and Biological Evaluation of the 3-Phenyl-1,4-benzothiazine Analogues 98
Synthesis of 2-(Arylamino)ethanethiols via Lewis Acid catalyzed Aminolysis of 2,2-Dimethylthiirane as Precursors of the 1,4-Benzothiazine Nucleus 97
Studies on 2-phenylquinoline Staphylococcus aureus NorA efflux pump inhibitors: New insights on the C-6 position 97
6-Aminoquinolones targeting HCV NS5B polymerase. 96
The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen-Activated Protein Kinase Inhibitors 96
Sustainable, three-component, one-pot procedure to obtain active anti-flavivirus agents 95
Studies of Anti-HIV Transcription Inhibitor Quinolones: Identification of Potent N1-Vinyl Derivatives 93
New C-6 functionalized quinoline NorA inhibitors strongly synergize with ciprofloxacin against planktonic and biofilm growing resistant Staphylococcus aureus strains 92
Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase 92
Structural optimization of the 2-Phenyl-4-hydroxyquinoline Class of S. aureus NorA Efflux Pump Inhibitors 92
Modulating microRNA Processing: Enoxacin, the Progenitor of a New Class of Drugs 92
Structural Modifications of 2-phenylquinoline Inhibitors of S. aureus MDR NorA efflux pump 91
Structure-based insights into p38α MAPK: from crystal structures analysis to hit optimization 91
Comprehensive response to usutu virus following first isolation in blood donors in the friuli venezia giulia region of italy: Development of recombinant ns1-based serology and sensitivity to antiviral drugs 91
Studies on Anti-HIV Quinolones: New Insights on the C-6 Position 90
Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium 89
Modifications on C6 and C7 Positions of 3-Phenylquinolone Efflux Pump Inhibitors Led to Potent and Safe Antimycobacterial Treatment Adjuvants 87
Structure modifications of 6-aminoquinolones with potent anti-HIV activity 86
Functionalized sulfonyl anthranilic acid derivatives inhibit replication of all the four dengue serotypes 85
Structural Modifications of 2-phenylquinoline Inhibitors of S. aureus MDR NorA efflux pump 85
Lipid nanoparticles for brain targeting III. Long-term stability and in vivo toxicity 85
Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor 85
Exploring the cycloheptathiophene-3-carboxamide scaffold to disrupt the interactions of the influenza polymerase subunits and obtain potent anti-influenza activity 85
Cycloheptathiophene-3-carboxamide derivatives as influenza A virus polymerase inhibitors 83
Novel 1,4-Benzothiazine Derivatives as Large Conductance Ca2+-Activated Potassium Channel Openers 80
Boosting Effect of 2-Phenylquinoline Efflux Inhibitors in Combination with Macrolides against Mycobacterium smegmatis and Mycobacterium avium 80
Mode of action of the 2-phenylquinoline efflux inhibitor PQQ4R against Escherichia coli 80
Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands 79
Searching New HCV NS5B Polymerase Inhibithors 78
Nuovi chemotipi di inibitori dell'HCV NS5B polimerasi 77
Structural Investigation of Cycloheptathiophene-3-carboxamide Derivatives Targeting Influenza Virus Polymerase Assembly 77
Re-evolution of the 2-phenylquinolines: Ligand-Based Design, Synthesis, and Biological Evaluation of a Potent New Class of Staphylococcus aureus NorA Efflux Pump Inhibitors to Combat Antimicrobial Resistance 77
Novel N-benzyl-1,4-benzothiazine derivates as large conductance Ca2+-activated potassium channel activators 76
Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity 75
TARGETING CDKs TO INHIBIT THE HIV-1 TAT-MEDIATED TRANSCRIPTION 75
Discovery of 2‐phenylquinazolines as potent Mycobacterium avium efflux pump inhibitors able to synergize with clarithromycin against clinical isolate 74
Structural investigation of the naphthyridone scaffold: identification of a 1,6-naphthyridone derivative with potent and selective anti-HIV activity. 73
DERIVATI 2-FENIL-4-IDROSSI-CHINOLINICI COME POTENTI INBITORI DELLA POMPA D’EFFLUSSO NorA DELLO S. aureus 73
Effetto inibitorio di derivati acridonici sulla replicazione del virus dell'epatite C (HCV) 71
New chemotypes to fight HCV infection: discovery of selective inhibitors of HCV replication with pyrazolobenzothiazine scaffold 70
Small molecole targeting HPV E6 and E7 oncoproteins expression. 70
Selective anti-BVDV acridones as new potential anti-HCV agents 69
Structure-Based Discovery of Pyrazolobenzothiazine Derivatives As Inhibitors of Hepatitis C Virus Replication 68
Virucidal Activity of the Pyridobenzothiazolone Derivative HeE1-17Y against Enveloped RNA Viruses 67
Targeting the HIV Tat-mediated transcriptional machinery: P-TEFb complex inhibitors 66
Small Molecule Drugs Targeting Viral Polymerases 65
Effetto Inibitorio di derivati Acridonici sulla Replicazione del virus dell’epatite C (HCV). 65
The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors 65
SMALL MOLECULES TARGETING HPV E6 AND E7 ONCOPROTEINS EXPRESSION 64
Totale 12.535
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Categoria #
all - tutte 48.812
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 48.812
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021342 0 0 0 0 0 0 0 0 0 35 44 263
2021/2022991 27 154 17 63 76 12 32 267 61 32 115 135
2022/20231.780 111 312 23 162 155 172 1 100 619 14 76 35
2023/20242.850 42 114 29 16 18 22 2.263 22 71 41 93 119
2024/20251.969 23 158 73 182 202 122 234 115 336 104 282 138
2025/20264.023 268 249 196 508 595 418 747 238 484 320 0 0
Totale 13.549