MANFRONI, GIUSEPPE
 Distribuzione geografica
Continente #
AS - Asia 2.749
NA - Nord America 2.357
EU - Europa 1.921
OC - Oceania 7
AF - Africa 6
Continente sconosciuto - Info sul continente non disponibili 3
SA - Sud America 2
Totale 7.045
Nazione #
US - Stati Uniti d'America 2.355
CN - Cina 2.186
IT - Italia 461
IE - Irlanda 438
SE - Svezia 280
UA - Ucraina 263
VN - Vietnam 249
HK - Hong Kong 245
DE - Germania 108
RU - Federazione Russa 91
FI - Finlandia 88
BE - Belgio 60
GB - Regno Unito 42
FR - Francia 26
CH - Svizzera 15
JP - Giappone 15
RO - Romania 14
SG - Singapore 13
NL - Olanda 11
TR - Turchia 9
PL - Polonia 8
UZ - Uzbekistan 8
AU - Australia 7
LB - Libano 6
CZ - Repubblica Ceca 5
KR - Corea 5
AT - Austria 4
IR - Iran 4
PK - Pakistan 4
EG - Egitto 3
EU - Europa 3
IN - India 3
BG - Bulgaria 2
CA - Canada 2
CI - Costa d'Avorio 2
DK - Danimarca 2
BR - Brasile 1
CL - Cile 1
ES - Italia 1
HU - Ungheria 1
ID - Indonesia 1
IQ - Iraq 1
PT - Portogallo 1
ZA - Sudafrica 1
Totale 7.045
Città #
Guangzhou 2.073
Chandler 600
Dublin 438
Dong Ket 246
Hong Kong 239
Perugia 229
San Mateo 226
Jacksonville 136
Medford 103
Princeton 103
Altamura 95
Ann Arbor 83
Wilmington 80
Lawrence 66
Brussels 60
Fremont 54
Andover 53
Beijing 50
Redmond 32
Saint Petersburg 31
Dearborn 27
Spoleto 25
Boardman 24
Des Moines 24
Ashburn 23
Redwood City 21
West Jordan 20
Falls Church 19
Norwalk 19
Los Angeles 14
Helsinki 12
San Diego 11
San Giustino 11
Rome 10
Tokyo 10
Izmir 9
Moscow 9
San Paolo di Civitate 9
Woodbridge 9
New York 8
Singapore 8
Bucharest 7
Den Haag 7
Melbourne 7
Hanover 6
Seattle 6
Nanjing 5
Arak 4
Frankfurt Am Main 4
Lausanne 4
Philadelphia 4
Timisoara 4
Wuhan 4
Zhengzhou 4
Anguillara Sabazia 3
Dallas 3
Edinburgh 3
Fairfield 3
Hanoi 3
Kunming 3
Mit Ghamr 3
Napoli 3
Seoul 3
Simi Valley 3
Aachen 2
Abidjan 2
Auburn Hills 2
Campegine 2
Cerro Maggiore 2
Chengdu 2
Gujranwala 2
Hangzhou 2
Hefei 2
Houston 2
Jinan 2
Kagoya 2
Leeds 2
Mcallen 2
Milan 2
Naples 2
San Jose 2
Serra 2
Shanghai 2
Silver Spring 2
Tappahannock 2
Umbertide 2
Urbino 2
Xian 2
Absecon 1
Alameda 1
Albuquerque 1
Alfa 1
Amsterdam 1
Aosta 1
Baotou 1
Barcelona 1
Basra 1
Bastia 1
Budapest 1
Böblingen 1
Totale 5.475
Nome #
Structural investigation of Small Molecules Targeting Influenza A Virus Polymerase 2.090
1,4-Benzothiazine ATP-Sensitive Potassium Channel Openers: Modifications at the C-2 and C-6 Positions 215
1,2,4-triazolo[1,5-α]pyrimidines as a novel class of inhibitors of the HIV-1 reverse transcriptase-αssociated ribonuclease h activity 178
Sintesi di nuovi inibitori della pompa di efflusso NorA dello S. aureus: dalle 3-fenil-1,4-benzotiazine alle 2-fenilchinossaline 104
Structure-activity relationship study on anti-HIV 6-desfluoroquinolones. 84
Syhtesis and Biological Evaluation of 2-Phenylquinolones Targeted at Tat/TAR Recognition 83
Targeting CDKs to inhibit the HIV-1 TAT-mediated transcription 74
Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase 72
Inhibition of Subgenomic Hepatitis C Virus RNA Replication by Acridone Derivatives: Identification of an NS3 Helicase Inhibitor. 71
CYCLOHEPTATHIOPHENE-3-CARBOXAMIDE DERIVATIVES AS INFLUENZA A VIRUS POLYMERASE INHIBITORS 70
A Comprehensive Structural Overview of p38α MAPK in Complex with Type I Inhibitors 70
Disegno e Sintesi di Nuovi Inibitori Allosterici della NS5B Polimerasi dell'HCV 69
2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction 69
Allosteric inhibition of the hepatitis C virus NS5B polymerase: in silico strategies for drug discovery and development 69
Accounting for target flexibility and water molecules by docking to ensembles of target structures: The HCV NS5B Palm Site I inhibitors case study. 66
Synthesis of 2-(Arylamino)ethanethiols via Lewis Acid catalyzed Aminolysis of 2,2-Dimethylthiirane as Precursors of the 1,4-Benzothiazine Nucleus 65
6-Desfluoroquinolones as promising HIV transcription inhibitors 63
From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors 63
Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation 63
Antitubercular polyhalogenated phenothiazines and phenoselenazine with reduced binding to CNS receptors 63
Studies on Anti-HIV Quinolones: New Insights on the C-6 Position 62
Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors 62
The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen-Activated Protein Kinase Inhibitors 61
Advantageous Use of Ionic Liquids for the Synthesis of Pharmaceutically Relevant Quinolones 61
Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase 60
Structure-based insights into p38α MAPK: from crystal structures analysis to hit optimization 59
New Insights on KCa3.1 Channel Modulation 59
Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase 58
A new quinolone derivative with ultra-potent anti-HIV activity. 57
2-phenylquinolones as HIV-1 Tat/TAR interaction inhibitors 57
Evolution from a natural flavones nucleus to obtain 2-(4-Propoxyphenyl)quinoline derivatives as potent inhibitors of the S. aureus NorA efflux pump. 57
A New Promising Class of pyrazolobenzothiazine inhibitors of S. aureus NorA Efflux Pump 57
Bicyclic octahydrocyclohepta[b]pyrrol-4(1H)one derivatives as novel selective anti-hepatitis C virus agents 57
Studies on 2-phenylquinoline Staphylococcus aureus NorA efflux pump inhibitors: New insights on the C-6 position 57
A New Derivative with Ultra-Potent Anti-HIV Activity 56
A Broad Anti-influenza Hybrid Small Molecule that Potently Disrupts the Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Subunits Interaction 55
A Journey around the Medicinal Chemistry of Hepatitis C Virus Inhibitors Targeting NS4B: From Target to Preclinical Drug Candidates 55
Broad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions 55
Structural Modifications of the Quinolin-4-yloxy Core to Obtain New Staphylococcus aureus NorA Inhibitors 54
2-Phenylquinazolinone fragment imparts anti-CDKs and anti-HIV activities 53
Discovery of Novel Inhibitors of the NorA Multidrug Transporter of Staphylococcus aureus. 52
Searching for Novel Inhibitors of the S. aureus NorA Efflux Pump: Synthesis and Biological Evaluation of the 3-Phenyl-1,4-benzothiazine Analogues 52
C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors 52
N-Benzoyl-N-methylsulfonyl anthranilates: unexpected cyclization reaction to 4-alkoxy-2,1-benzothiazines 51
Structure modifications of 6-aminoquinolones with potent anti-HIV activity 50
Computer-Aided Identification of Fragments as CDK9 Inhibitors with Anti-HIV-1 Tat-Mediated Transcription Activity 50
Design and synthesis of WM5 analogues as HIV-1 TAR RNA binders. 50
Synthesis and Characterization of 1,2,4-Triazolo[1,5-a]pyrimidine-2-carboxamide-based Compounds Targeting the PA-PB1 Interface of Influenza A Virus Polymerase. 50
Computer-Aided Design, Synthesis and Validation of 2-Phenylquinazolinone Fragments as CDK9 Inhibitors with Anti-HIV-1 Tat-Mediated Transcription Activity 47
Evolution of HCV NS4B Inhibitors 47
New Pyrazolobenzothiazine Derivatives As Hepatitis C Virus NS5B Polymerase Palm Site I Inhibitors 47
Derivati 2-fenilchinolonici come inibitori della pompa di efflusso NorA dello Staphylococcus aureus ciprofloxacin resistente 46
Structural Modifications of 2-phenylquinoline Inhibitors of S. aureus MDR NorA efflux pump 46
Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor 46
Exploring the cycloheptathiophene-3-carboxamide scaffold to disrupt the interactions of the influenza polymerase subunits and obtain potent anti-influenza activity 46
Novel 1,4-Benzothiazine Derivatives as Large Conductance Ca2+-Activated Potassium Channel Openers 45
A Comprehensive Structural Overview of p38 Mitogen-Activated Protein Kinase in Complex with ATP-Site and Non-ATP-Site Binders 45
Re-evolution of the 2-phenylquinolines: Ligand-Based Design, Synthesis, and Biological Evaluation of a Potent New Class of Staphylococcus aureus NorA Efflux Pump Inhibitors to Combat Antimicrobial Resistance 44
Co-crystal structure determination and cellular evaluation of 1,4-dihydropyrazolo[4,3-c] [1,2] benzothiazine 5,5-dioxide p38α MAPK inhibitors 44
Effetto Inibitorio di derivati Acridonici sulla Replicazione del virus dell’epatite C (HCV). 43
Broad-Spectrum Flavivirus Inhibitors: a Medicinal Chemistry Point of View 43
Structure-Based Discovery of Pyrazolobenzothiazine Derivatives As Inhibitors of Hepatitis C Virus Replication 43
Searching New HCV NS5B Polymerase Inhibithors 42
Novel N-benzyl-1,4-benzothiazine derivates as large conductance Ca2+-activated potassium channel activators 42
6-Aminoquinolones targeting HCV NS5B polymerase. 42
Investigation on the effect of known potent S. aureus NorA efflux pump inhibitors on the staphylococcal biofilm formation 42
Studies of Anti-HIV Transcription Inhibitor Quinolones: Identification of Potent N1-Vinyl Derivatives 41
Cycloheptathiophene-3-carboxamide derivatives as influenza A virus polymerase inhibitors 41
Structural Modifications of 2-phenylquinoline Inhibitors of S. aureus MDR NorA efflux pump 40
Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands 40
Mode of action of the 2-phenylquinoline efflux inhibitor PQQ4R against Escherichia coli 40
DERIVATI 2-FENIL-4-IDROSSI-CHINOLINICI COME POTENTI INBITORI DELLA POMPA D’EFFLUSSO NorA DELLO S. aureus 39
Selective anti-BVDV acridones as new potential anti-HCV agents 39
New chemotypes to fight HCV infection: discovery of selective inhibitors of HCV replication with pyrazolobenzothiazine scaffold 39
Lipid nanoparticles for brain targeting III. Long-term stability and in vivo toxicity 39
Pyrazolo[4,3-c][1,2]benzothiazines 5,5-Dioxide: A Promising New Class of Staphylococcus aureus NorA Efflux Pump Inhibitors 38
Boosting Effect of 2-Phenylquinoline Efflux Inhibitors in Combination with Macrolides against Mycobacterium smegmatis and Mycobacterium avium 38
New C-6 functionalized quinoline NorA inhibitors strongly synergize with ciprofloxacin against planktonic and biofilm growing resistant Staphylococcus aureus strains 36
Discovery of the 2-phenyl-4,5,6,7-Tetrahydro-1H-indole as a novel anti-hepatitis C virus targeting scaffold 36
Modifications on C6 and C7 Positions of 3-Phenylquinolone Efflux Pump Inhibitors Led to Potent and Safe Antimycobacterial Treatment Adjuvants 36
Structural optimization of the 2-Phenyl-4-hydroxyquinoline Class of S. aureus NorA Efflux Pump Inhibitors 35
Tumour cell population growth inhibition and cell death induction of functionalized 6-aminoquinolone derivatives 35
Modulating microRNA Processing: Enoxacin, the Progenitor of a New Class of Drugs 35
Targeting the HIV Tat-mediated transcriptional machinery: P-TEFb complex inhibitors 34
The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors 34
Enantioresolution, stereochemical characterization and biological activity of a chiral large-conductance calcium-activated potassium channel opener. 34
From Quinoline to Quinazoline-Based S. aureus NorA Efflux Pump Inhibitors by Coupling a Focused Scaffold Hopping Approach and a Pharmacophore Search 34
Effetto inibitorio di derivati acridonici sulla replicazione del virus dell'epatite C (HCV) 33
Nuovi chemotipi di inibitori dell'HCV NS5B polimerasi 33
Structural investigation of the naphthyridone scaffold: identification of a 1,6-naphthyridone derivative with potent and selective anti-HIV activity. 32
Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium 32
Studies on anti-HIV Quinolones 31
STRUCTURAL INVESTIGATIONS OF THE 2-PHENYL-4- HYDROXYQUINOLINE CLASS OF S. AUREUS NORA EPIS 31
Small molecole targeting HPV E6 and E7 oncoproteins expression. 30
Synthesis and anti-BVDV activity of acridones as new potential antiviral agents 30
Structural Investigation of Cycloheptathiophene-3-carboxamide Derivatives Targeting Influenza Virus Polymerase Assembly 28
Ethyl 1,8-Naphthyridone-3-carboxylates Downregulate Human Papillomavirus-16 (HPV-16) E6 and E7 Oncogenes Expression 28
SMALL MOLECULES TARGETING HPV E6 AND E7 ONCOPROTEINS EXPRESSION 27
Studies on Cycloheptathiophene-3-carboxamide Derivatives as Allosteric HIV-1 Ribonuclease H Inhibitors 26
TARGETING CDKs TO INHIBIT THE HIV-1 TAT-MEDIATED TRANSCRIPTION 24
Totale 7.228
Categoria #
all - tutte 21.525
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 21.525


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/201920 0 0 0 0 0 0 0 0 0 0 14 6
2019/2020400 5 4 45 3 39 37 78 10 68 79 8 24
2020/20211.051 13 59 35 63 241 93 109 9 87 35 44 263
2021/2022991 27 154 17 63 76 12 32 267 61 32 115 135
2022/20231.780 111 312 23 162 155 172 1 100 619 14 76 35
2023/20242.672 42 114 29 16 18 22 2.263 22 71 41 34 0
Totale 7.379